node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rv0658c | mazE2 | Rv0658c | Rv0660c | Rv0658c, (MTCI376.18), len: 238 aa. Probable conserved integral membrane protein, equivalent to a predicted homologous protein from Mycobacterium smegmatis (see citation below), and showing some similarity with P33774|YPRB_ECOLI hypothetical 24.3 kDa protein from Escherichia coli (217 aa), FASTA scores: opt: 174, E(): 5.3e-05, (25.6% identity in 223 aa overlap). Also similar to Rv1863c and Rv0804 from Mycobacterium tuberculosis. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007). | Possible antitoxin MazE2; Antitoxin component of a type II toxin-antitoxin (TA) system. | 0.420 |
Rv0658c | mazF2 | Rv0658c | Rv0659c | Rv0658c, (MTCI376.18), len: 238 aa. Probable conserved integral membrane protein, equivalent to a predicted homologous protein from Mycobacterium smegmatis (see citation below), and showing some similarity with P33774|YPRB_ECOLI hypothetical 24.3 kDa protein from Escherichia coli (217 aa), FASTA scores: opt: 174, E(): 5.3e-05, (25.6% identity in 223 aa overlap). Also similar to Rv1863c and Rv0804 from Mycobacterium tuberculosis. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007). | Toxin MazF2; Toxic component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli partially inhibits cell growth after one cell generation. Its cognate antitoxin is MazE2. Probably an endoribonuclease (By similarity); Belongs to the PemK/MazF family. | 0.443 |
mazE1 | mazE2 | Rv0456B | Rv0660c | Possible antitoxin MazE1; Antitoxin component of a type II toxin-antitoxin (TA) system. | Possible antitoxin MazE2; Antitoxin component of a type II toxin-antitoxin (TA) system. | 0.870 |
mazE1 | mazE3 | Rv0456B | Rv1103c | Possible antitoxin MazE1; Antitoxin component of a type II toxin-antitoxin (TA) system. | Possible antitoxin MazE3; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and M.smegmatis neutralizes the effect of cognate toxin MazF3. Overexpression of MazE3 alone decreased persister cells formation in M.smegmatis upon challenge with gentamicin or kanamycin. | 0.658 |
mazE1 | mazE6 | Rv0456B | Rv1991A | Possible antitoxin MazE1; Antitoxin component of a type II toxin-antitoxin (TA) system. | Antitoxin MazE6; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and in M.smegmatis counteracts the ribonuclease activity of cognate toxin MazF6. | 0.803 |
mazE1 | mazE8 | Rv0456B | Rv2274A | Possible antitoxin MazE1; Antitoxin component of a type II toxin-antitoxin (TA) system. | Possible antitoxin MazE8; Antitoxin component of a type II toxin-antitoxin (TA) system. Its cognate toxin is MazF8. | 0.803 |
mazE1 | mazF6 | Rv0456B | Rv1991c | Possible antitoxin MazE1; Antitoxin component of a type II toxin-antitoxin (TA) system. | Toxin MazF6; Toxic component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and in M.smegmatis partially inhibits cell growth and colony formation; its toxic effect is neutralized by coexpression with cognate antitoxin MazE6. Acts as an mRNA interferase on ssRNA, cleaving between the second and third bases in the sequences CUCCU and UUCCU. Further experiments demonstrate that it digests between the first and second bases of UCCUU, yielding a 5'- hydroxyl end; digests M.tuberculosis mRNA (in coding as well as the 5'- and 3'-UTR regions) and 23S rRNA, digests E.coli [...] | 0.642 |
mazE2 | Rv0658c | Rv0660c | Rv0658c | Possible antitoxin MazE2; Antitoxin component of a type II toxin-antitoxin (TA) system. | Rv0658c, (MTCI376.18), len: 238 aa. Probable conserved integral membrane protein, equivalent to a predicted homologous protein from Mycobacterium smegmatis (see citation below), and showing some similarity with P33774|YPRB_ECOLI hypothetical 24.3 kDa protein from Escherichia coli (217 aa), FASTA scores: opt: 174, E(): 5.3e-05, (25.6% identity in 223 aa overlap). Also similar to Rv1863c and Rv0804 from Mycobacterium tuberculosis. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007). | 0.420 |
mazE2 | mazE1 | Rv0660c | Rv0456B | Possible antitoxin MazE2; Antitoxin component of a type II toxin-antitoxin (TA) system. | Possible antitoxin MazE1; Antitoxin component of a type II toxin-antitoxin (TA) system. | 0.870 |
mazE2 | mazE3 | Rv0660c | Rv1103c | Possible antitoxin MazE2; Antitoxin component of a type II toxin-antitoxin (TA) system. | Possible antitoxin MazE3; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and M.smegmatis neutralizes the effect of cognate toxin MazF3. Overexpression of MazE3 alone decreased persister cells formation in M.smegmatis upon challenge with gentamicin or kanamycin. | 0.870 |
mazE2 | mazE4 | Rv0660c | Rv1494 | Possible antitoxin MazE2; Antitoxin component of a type II toxin-antitoxin (TA) system. | Possible antitoxin MazE4; Antitoxin component of a type II toxin-antitoxin (TA) system. In M.smegmatis neutralizes the toxic effect of mRNA interferase MazF4, its cognate toxin, on growth. | 0.414 |
mazE2 | mazE6 | Rv0660c | Rv1991A | Possible antitoxin MazE2; Antitoxin component of a type II toxin-antitoxin (TA) system. | Antitoxin MazE6; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and in M.smegmatis counteracts the ribonuclease activity of cognate toxin MazF6. | 0.803 |
mazE2 | mazE8 | Rv0660c | Rv2274A | Possible antitoxin MazE2; Antitoxin component of a type II toxin-antitoxin (TA) system. | Possible antitoxin MazE8; Antitoxin component of a type II toxin-antitoxin (TA) system. Its cognate toxin is MazF8. | 0.870 |
mazE2 | mazF2 | Rv0660c | Rv0659c | Possible antitoxin MazE2; Antitoxin component of a type II toxin-antitoxin (TA) system. | Toxin MazF2; Toxic component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli partially inhibits cell growth after one cell generation. Its cognate antitoxin is MazE2. Probably an endoribonuclease (By similarity); Belongs to the PemK/MazF family. | 0.903 |
mazE2 | mazF6 | Rv0660c | Rv1991c | Possible antitoxin MazE2; Antitoxin component of a type II toxin-antitoxin (TA) system. | Toxin MazF6; Toxic component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and in M.smegmatis partially inhibits cell growth and colony formation; its toxic effect is neutralized by coexpression with cognate antitoxin MazE6. Acts as an mRNA interferase on ssRNA, cleaving between the second and third bases in the sequences CUCCU and UUCCU. Further experiments demonstrate that it digests between the first and second bases of UCCUU, yielding a 5'- hydroxyl end; digests M.tuberculosis mRNA (in coding as well as the 5'- and 3'-UTR regions) and 23S rRNA, digests E.coli [...] | 0.661 |
mazE2 | vapB7 | Rv0660c | Rv0662c | Possible antitoxin MazE2; Antitoxin component of a type II toxin-antitoxin (TA) system. | Possible antitoxin VapB7; Antitoxin component of a possible type II toxin-antitoxin (TA) system. The cognate toxin is VapC7. | 0.562 |
mazE2 | vapC7 | Rv0660c | Rv0661c | Possible antitoxin MazE2; Antitoxin component of a type II toxin-antitoxin (TA) system. | Possible toxin VapC7; Toxic component of a type II toxin-antitoxin (TA) system. An RNase. The cognate antitoxin is VapB7 (By similarity). Belongs to the PINc/VapC protein family. | 0.561 |
mazE3 | mazE1 | Rv1103c | Rv0456B | Possible antitoxin MazE3; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and M.smegmatis neutralizes the effect of cognate toxin MazF3. Overexpression of MazE3 alone decreased persister cells formation in M.smegmatis upon challenge with gentamicin or kanamycin. | Possible antitoxin MazE1; Antitoxin component of a type II toxin-antitoxin (TA) system. | 0.658 |
mazE3 | mazE2 | Rv1103c | Rv0660c | Possible antitoxin MazE3; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and M.smegmatis neutralizes the effect of cognate toxin MazF3. Overexpression of MazE3 alone decreased persister cells formation in M.smegmatis upon challenge with gentamicin or kanamycin. | Possible antitoxin MazE2; Antitoxin component of a type II toxin-antitoxin (TA) system. | 0.870 |
mazE3 | mazE6 | Rv1103c | Rv1991A | Possible antitoxin MazE3; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and M.smegmatis neutralizes the effect of cognate toxin MazF3. Overexpression of MazE3 alone decreased persister cells formation in M.smegmatis upon challenge with gentamicin or kanamycin. | Antitoxin MazE6; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and in M.smegmatis counteracts the ribonuclease activity of cognate toxin MazF6. | 0.871 |