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Rv0792c Rv0792c Rv0790c Rv0790c Rv0791c Rv0791c Rv0793 Rv0793 Rv0789c Rv0789c Rv0494 Rv0494 Rv2345 Rv2345 Rv3833 Rv3833 higA3 higA3 Rv3060c Rv3060c Rv2912c Rv2912c
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
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[Homology]
Score
Rv0792cProbable transcriptional regulatory protein (probably GntR-family); Rv0792c, (MTV042.02c), len: 269 aa. Probable transcriptional regulator, GntR-family, similar to many others of GntR family e.g. BSUB0018_189|Z99121 from Bacillus subtilis (243 aa), FASTA scores: opt: 367, E(): 1.5e-17, (32.1% identity in 246 aa overlap); P31453|YIDP_ECOLI from Escherichia coli (238 aa), FASTA scores: opt: 236, E(): 8.8e-09, (26.4% identity in 235 aa overlap); etc. (269 aa)    
Predicted Functional Partners:
Rv0790c
Hypothetical protein; Rv0790c, (MTCY369.34c), len: 242 aa. Hypothetical unknown protein.
 
  
 0.977
Rv0791c
Conserved protein; Rv0791c, (MTV042.01c, MTCY369.35c), len: 347 aa. Conserved protein, similar (except in N-terminus) to others e.g. CAC44585.1|AL596162 conserved hypothetical protein from Streptomyces coelicolor (307 aa); NP_252643.1|NC_002516 hypothetical protein from Pseudomonas aeruginosa (364 aa); etc. Also some similarity with oxidoreductases e.g. AAK38097.1|AF323606_3|AF323606 putative F420-dependent dehydrogenase from Rhodococcus erythropolis (295 aa); etc. And also similar in part to other proteins from Mycobacterium tuberculosis e.g. Rv1855c|MTCY359.18|Z83859 (307 aa), FASTA [...]
  
  
 0.976
Rv0793
Possible monooxygenase; Putative monooygenase that might be involved in antibiotic biosynthesis, or may act as reactive oxygen species scavenger that could help in evading host defenses.
 
  
 0.945
Rv0789c
Hypothetical protein; Rv0789c, (MTCY369.33c), len: 199 aa. Hypothetical unknown protein.
  
  
 0.903
Rv0494
Probable transcriptional regulatory protein (probably GntR-family); Rv0494, (MTCY20G9.20), len: 242 aa. Probable transcriptional regulator, GntR family, with C-terminal part highly similar to S72893|B2168_C2_205 hypothetical protein from Mycobacterium leprae (105 aa). Also similar to other transcription regulators e.g. PDHR_ECOLI|P06957 pyruvate dehydrogenase complex repressor PDHR or GENA from Escherichia coli (254 aa), FASTA scores: opt: 284, E(): 1.2e-11, (32.6% identity in 224 aa overlap); etc. Contains PS00043 Bacterial regulatory proteins, gntR family signature, and probable heli [...]
 
  
 0.862
Rv2345
Possible conserved transmembrane protein; May play a role in septum formation. Belongs to the UPF0603 family.
   
  
 0.862
Rv3833
Transcriptional regulatory protein (probably AraC-family); Rv3833, (MTCY01A6.36c), len: 263 aa. Probable transcriptional regulator belonging to araC family, similar to others e.g. Q9KYN4|SC9H11.05 putative AraC-family transcriptional regulator from Streptomyces coelicolor (289 aa), FASTA scores: opt: 754, E(): 1.2e-42, (50.45% identity in 232 aa overlap); Q9HXH2|PA3830 probable transcriptional regulator from Pseudomonas aeruginosa (270 aa), FASTA scores: opt: 501, E(): 6.2e-26, (34.85% identity in 238 aa overlap); Q9HX87|PA3927 probable transcriptional regulator from Pseudomonas aerugi [...]
  
  
 0.842
higA3
Possible transcriptional regulatory protein; Putative antitoxin component of a type II toxin-antitoxin (TA) system. Its cognate toxin would be HigB3.
  
  
 0.814
Rv3060c
Rv3060c, (MTCY22D7.21), len: 490 aa. Probable transcriptional regulatory protein, showing reasonable similarity to several members of the GntR family e.g. BAB54431|MLL8575 from Rhizobium loti (Mesorhizobium loti) (247 aa), FASTA scores: opt: 274, E(): 3.5e-10, (30.35% identity in 224 aa overlap); P96570|ESMR from Burkholderia cepacia (Pseudomonas cepacia) (277 aa), FASTA scores: opt: 229, E(): 2.8e-07, (25.85% identity in 240 aa overlap); Q9S276|SCI28.07 from Streptomyces coelicolor (230 aa),FASTA scores: opt: 211, E(): 3.4e-06, (27.25% identity in 220 aa overlap); etc. Seems to have t [...]
 
  
 0.811
Rv2912c
Rv2912c, (MTCY274.44c), len: 195 aa. Probable transcription regulatory protein, TetR family, showing similarity with others e.g. Q9K3V9|SCD10.17 putative TetR-family transcriptional from Streptomyces coelicolor (202 aa), FASTA scores: opt: 185, E(): 4.4e-05, (31.15% identity in 167 aa overlap); Q9KFQ0 TetR-family from Bacillus halodurans (185 aa), FASTA scores: opt: 164, E(): 0.001, (35.6% identity in 73 aa overlap); P17446|BETI_ECOLI|BETI|B0313 regulatory protein from Escherichia coli strain K12 (195 aa), FASTA scores: opt: 126, E(): 0.024, (24.5% identity in 196 aa overlap); etc. Con [...]
   
  
 0.805
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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