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moaC2 moaC2 mog mog moaA2 moaA2 moaA1 moaA1 moaE2 moaE2 moaX moaX moaE1 moaE1 moaB2 moaB2 moaC3 moaC3 moaC1 moaC1 moeA2 moeA2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Score
moaC2Probable molybdenum cofactor biosynthesis protein C 2 MoaC2; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (167 aa)    
Predicted Functional Partners:
mog
Rv0865, (MTV043.58), len: 160 aa. Probable mog,molybdopterin biosynthesis MOG protein, highly similar or similar to other molybdenum cofactor biosynthesis proteins e.g. CAB59675.1|AL132674 molybdenum cofactor biosynthesis protein from Streptomyces coelicolor (179 aa); NP_301253.1|NC_002677 putative molybdenum cofactor biosynthesis protein from Mycobacterium leprae (181 aa); CAC39235.1|AJ312124 Mog protein from Eubacterium acidaminophilum (162 aa); P44645|MOG_HAEIN|MOGA|HI0336 molybdopterin biosynthesis MOG protein from Haemophilus influenzae (197 aa), FASTA scores: opt: 306, E(): 9e-13 [...]
  
 0.999
moaA2
Probable molybdenum cofactor biosynthesis protein A2 MoaA2; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate.
 
 0.999
moaA1
Probable molybdenum cofactor biosynthesis protein A MoaA1; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family.
 
 0.999
moaE2
Molybdopterin synthase catalytic subunit 2; Converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by MoaD (By similarity); Belongs to the MoaE family.
 
 0.998
moaX
Rv3323c, (MTV016.23c), len: 221 aa. Probable moaX,MoaD-MoaE fusion protein, similar (whole or partial) to several MoaD and MoaE proteins e.g. Q9RR88|DR2607 molybdenum cofactor biosynthesis protein D/E from Deinococcus radiodurans (229 aa), FASTA scores: opt: 407,E(): 1.8e-18, (32.75% identity in 223 aa overlap); Q9K8I7|MOAE|BH3019 molybdopterin converting factor (subunit 2) from Bacillus halodurans (156 aa), FASTA scores: opt: 375, E(): 1.3e-16, (41.65% identity in 132 aa overlap); O31705|MOAE molybdopterin converting factor (subunit 2) from Bacillus subtilis (157 aa), FASTA scores: op [...]
 
 0.998
moaE1
Molybdopterin synthase catalytic subunit 1; Converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by MoaD (By similarity); Belongs to the MoaE family.
 
 0.980
moaB2
MoCF_biosynth domain-containing protein; Rv0984, (MTV044.12), len: 181 aa. Possible moaB2,pterin-4-alpha-carbinolamine dehydratase, highly similar to NP_301253.1|NC_002677 putative molybdenum cofactor biosynthesis protein from Mycobacterium leprae (181 aa),FASTA score: (92.3% identity in 181 aa overlap). Also similar to others e.g. CAB59675.1|AL132674 molybdenum cofactor biosynthesis protein from Streptomyces coelicolor (179 aa); Q56208|MOCB_SYNP7 molybdenum cofactor biosynthesis protein CB from Synechococcus sp. (319 aa),FASTA score: (37.3% identity in 142 aa overlap); C-terminus of N [...]
  
 0.915
moaC3
Probable molybdenum cofactor biosynthesis protein C 3 MoaC3; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family.
  
 
0.915
moaC1
Probable molybdenum cofactor biosynthesis protein C MoaC1; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) (By similarity). Probably plays a role in host phagosome maturation arrest ; Belongs to the MoaC family.
  
 
0.913
moeA2
Probable molybdopterin biosynthesis protein MoeA2; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.
 
  
 0.884
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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