Potassium-transporting ATPase potassium-binding subunit; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane.

Potassium-transporting ATPase KdpC subunit; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.

Probable sensor protein KdpD; Member of the two-component regulatory system KdpD/KdpE involved in the regulation of the kdp operon. Functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to the conserved aspartic acid residue in the regulatory domain of KdpE in response to environmental signals such as low levels of potassium ion, osmotic imbalance, acid and nutrient stresses. In turn, KdpE binds to the upstream promoter regions of target genes to positively regulate their expression.

Possible membrane protein; Required for wild-type expression of ArfA and ammonia secretion, not however part of an ammonia transporter. Belongs to the ArfB membrane protein family.

Probable transcriptional regulatory protein KdpE; Member of the two-component regulatory system KdpD/KdpE involved in the regulation of the kdp operon. Upon phosphorylation by KdpD, functions as a transcription regulator by direct binding to promoter regions of target genes to positively regulate their expression.

Adenylate cyclase (ATP pyrophosphate-lyase) (adenylyl cyclase); Rv1647, (MTCY06H11.12), len: 316 aa. Adenylate cyclase, some similarity to other Mycobacterium tuberculosis proteins e.g. Q11055|Rv1264|YC64_MYCTU 42.2 kDa protein (397 aa), FASTA scores: opt: 197, E(): 9.4e-06,(27.1% identity in 181 aa overlap) and Q10400|Rv2212|YM12_MYCTU (378 aa). Belongs to adenylyl cyclase class-3 family.

Adenylyl cyclase (ATP pyrophosphate-lyase) (adenylate cyclase); Rv2212, (MTCY190.23), len: 378 aa. Adenylyl cyclase (See Abdel Motaal et al., 2006). Some similarity to e.g. SW:CYAA_STRCO P40135 adenylate cyclase (29.2% identity in 291 aa overlap); ttg at 24614 in MTCY190 has a better rbs. Contains possible helix-turn-helix motif at aa 64-85,(+2.72 SD). Also similar to Rv1264 and Rv1647.

Probable lipoprotein LprJ; Overexpression induces expression of sensor protein kdpD gene at low K(+) concentrations (0 and 250 uM, tested in M.smegatis).

Possible adenylate cyclase (ATP pyrophosphate-lyase) (adenylyl cyclase); Rv1318c, (MTCY130.03c), len: 541 aa. Possible adenylate cyclase. Some similarity at the c-terminus to CYAA_RHIME|P19485 adenylate cyclase from Rhizobium meliloti (193 aa), FASTA scores, opt: 270, E(): 2.5e-11, (28.8% identity in 184 aa overlap); similar to other mycbacterium tuberculosis putative adenylate cyclases e.g. Rv1319c|MTCY130.04c (535 aa), FASTA scores: opt: 2505, E(): 0, (71.0% identity in 534 aa overlap), also similar to Rv1320c|MTCY130.05c (567 aa), FASTA scores, opt: 2423, E(): 0, (68.7% identity in [...]