node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PE9 | Rv1115 | Rv1088 | Rv1115 | PE family protein PE9; Together with PE10, induces macrophage apoptosis through human Toll-like receptor 4 (TLR4) signaling pathway. Interaction with TLR4 leads to increased levels of phospho-IRF-3, increase in the transcript levels of IFN-beta and pro-apoptotic genes, up-regulation of IL-10, down-regulation of IL-1b and enhanced levels of macrophage apoptosis. | Possible exported protein; Rv1115, (MTCY22G8.04), len: 232 aa. Possible exported protein, contains possible N-terminal signal sequence. | 0.651 |
PE9 | Rv2190c | Rv1088 | Rv2190c | PE family protein PE9; Together with PE10, induces macrophage apoptosis through human Toll-like receptor 4 (TLR4) signaling pathway. Interaction with TLR4 leads to increased levels of phospho-IRF-3, increase in the transcript levels of IFN-beta and pro-apoptotic genes, up-regulation of IL-10, down-regulation of IL-1b and enhanced levels of macrophage apoptosis. | Conserved hypothetical protein; Rv2190c, (MTV021.23c, MTCY190.01c), len: 385 aa. Conserved hypothetical protein; similar to other hypothetical mycobacterial proteins, including Rv1477,Rv1478, Rv1566c, Rv0024, that are similar to protein p60 precursors from Listeria e.g. Q018 38|P60_LISSE protein p60 precursor (invasion-associated protein) (524 aa). FASTA scores: gp|Z80233|MTCY10H4_25 (281 aa) opt: 290, E(): 6.9e-05; 37.0% identity in 127 aa overlap and sp|Q01838|P60_LISSE protein P60 precursor (523 aa) opt: 268, E(): 0.00071; 38.5% identity in 104 aa overlap; Belongs to the peptidase C [...] | 0.414 |
PE_PGRS25 | Rv1115 | Rv1396c | Rv1115 | PE-PGRS family protein PE_PGRS25; Rv1396c, (MTCY21B4.13c), len: 576 aa. PE_PGRS25,Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see Brennan & Delogu 2002),strong similarity to many e.g. glycine rich protein MTCY130.10C|E245019 (603 aa), FASTA scores: opt: 1945, E(): 0, (57.5% identity in 619 aa overlap). Contains PS00017 ATP/GTP-binding site motif A, similar to other PGRS-type sequences. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007). | Possible exported protein; Rv1115, (MTCY22G8.04), len: 232 aa. Possible exported protein, contains possible N-terminal signal sequence. | 0.652 |
PE_PGRS25 | Rv2190c | Rv1396c | Rv2190c | PE-PGRS family protein PE_PGRS25; Rv1396c, (MTCY21B4.13c), len: 576 aa. PE_PGRS25,Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see Brennan & Delogu 2002),strong similarity to many e.g. glycine rich protein MTCY130.10C|E245019 (603 aa), FASTA scores: opt: 1945, E(): 0, (57.5% identity in 619 aa overlap). Contains PS00017 ATP/GTP-binding site motif A, similar to other PGRS-type sequences. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007). | Conserved hypothetical protein; Rv2190c, (MTV021.23c, MTCY190.01c), len: 385 aa. Conserved hypothetical protein; similar to other hypothetical mycobacterial proteins, including Rv1477,Rv1478, Rv1566c, Rv0024, that are similar to protein p60 precursors from Listeria e.g. Q018 38|P60_LISSE protein p60 precursor (invasion-associated protein) (524 aa). FASTA scores: gp|Z80233|MTCY10H4_25 (281 aa) opt: 290, E(): 6.9e-05; 37.0% identity in 127 aa overlap and sp|Q01838|P60_LISSE protein P60 precursor (523 aa) opt: 268, E(): 0.00071; 38.5% identity in 104 aa overlap; Belongs to the peptidase C [...] | 0.412 |
Rv0104 | Rv1115 | Rv0104 | Rv1115 | Rv0104, (MTCY251.23), len: 504 aa. Conserved hypothetical protein, showing weak similarity with other cAMP-dependent protein kinases e.g. AAC37564.1|M65066 cAMP-dependent protein kinase RI-beta regulatory subunit from Homo sapiens (380 aa); etc. | Possible exported protein; Rv1115, (MTCY22G8.04), len: 232 aa. Possible exported protein, contains possible N-terminal signal sequence. | 0.803 |
Rv0232 | Rv1111c | Rv0232 | Rv1111c | Rv0232, (MTCY08D5.28), len: 229 aa. Probable transcriptional regulatory protein, TetR/AcrR family,similar to others e.g. YIXD_BACSU|P32398 hypothetical transcriptional regulator (191 aa), FASTA scores: opt: 149,E(): 0.0014, (21.5% identity in 158 aa overlap). Also similar to MTV030_11 from Mycobacterium tuberculosis. Contains PS01081 Bacterial regulatory proteins, TetR family signature, and probable helix-turn helix motif from aa 33-54 (Score 1142, +3.08 SD). Belongs to the TetR/AcrR family of transcriptional regulators. | Rv1111c, (MTV017.64c), len: 327 aa. Conserved hypothetical protein, N-terminal domain is hydrophobic,C-terminal half is very rich in Arg. Equivalent to AL049491|MLCB1222_2 hypothetical protein from Mycobacterium leprae (379 aa) (46.0% identity in 374 aa overlap). Start changed since first submission. A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al.,2004). | 0.806 |
Rv0232 | Rv1115 | Rv0232 | Rv1115 | Rv0232, (MTCY08D5.28), len: 229 aa. Probable transcriptional regulatory protein, TetR/AcrR family,similar to others e.g. YIXD_BACSU|P32398 hypothetical transcriptional regulator (191 aa), FASTA scores: opt: 149,E(): 0.0014, (21.5% identity in 158 aa overlap). Also similar to MTV030_11 from Mycobacterium tuberculosis. Contains PS01081 Bacterial regulatory proteins, TetR family signature, and probable helix-turn helix motif from aa 33-54 (Score 1142, +3.08 SD). Belongs to the TetR/AcrR family of transcriptional regulators. | Possible exported protein; Rv1115, (MTCY22G8.04), len: 232 aa. Possible exported protein, contains possible N-terminal signal sequence. | 0.627 |
Rv0232 | eccC4 | Rv0232 | Rv3447c | Rv0232, (MTCY08D5.28), len: 229 aa. Probable transcriptional regulatory protein, TetR/AcrR family,similar to others e.g. YIXD_BACSU|P32398 hypothetical transcriptional regulator (191 aa), FASTA scores: opt: 149,E(): 0.0014, (21.5% identity in 158 aa overlap). Also similar to MTV030_11 from Mycobacterium tuberculosis. Contains PS01081 Bacterial regulatory proteins, TetR family signature, and probable helix-turn helix motif from aa 33-54 (Score 1142, +3.08 SD). Belongs to the TetR/AcrR family of transcriptional regulators. | Rv3447c, (MTCY77.19c), len: 1236 aa. EccC4, esx conserved component, ESX-4 type VII secretion system protein, probable membrane protein, similar to various bacterial proteins e.g. O86653|SC3C3.20c ATP/GTP binding protein from Streptomyces coelicolor (1321 aa), FASTA scores: opt: 1186, E(): 1.9e-60, (42.9% identity in 1312 aa overlap); Q9L0T6|SCD35.15c from Streptomyces coelicolor (1525 aa), FASTA scores: opt: 932, E(): 9.2e-46, (27.2% identity in 1374 aa overlap); Q9CD30|ML2535 hypothetical protein from Mycobacterium leprae (1329 aa), FASTA scores: opt: 910, E(): 1.5e-44, (34.4% identi [...] | 0.765 |
Rv0232 | pimF | Rv0232 | Rv1500 | Rv0232, (MTCY08D5.28), len: 229 aa. Probable transcriptional regulatory protein, TetR/AcrR family,similar to others e.g. YIXD_BACSU|P32398 hypothetical transcriptional regulator (191 aa), FASTA scores: opt: 149,E(): 0.0014, (21.5% identity in 158 aa overlap). Also similar to MTV030_11 from Mycobacterium tuberculosis. Contains PS01081 Bacterial regulatory proteins, TetR family signature, and probable helix-turn helix motif from aa 33-54 (Score 1142, +3.08 SD). Belongs to the TetR/AcrR family of transcriptional regulators. | Probable glycosyltransferase; May play only a redundant role in maintaining cell wall viability and bacterial virulence. | 0.544 |
Rv1111c | Rv0232 | Rv1111c | Rv0232 | Rv1111c, (MTV017.64c), len: 327 aa. Conserved hypothetical protein, N-terminal domain is hydrophobic,C-terminal half is very rich in Arg. Equivalent to AL049491|MLCB1222_2 hypothetical protein from Mycobacterium leprae (379 aa) (46.0% identity in 374 aa overlap). Start changed since first submission. A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al.,2004). | Rv0232, (MTCY08D5.28), len: 229 aa. Probable transcriptional regulatory protein, TetR/AcrR family,similar to others e.g. YIXD_BACSU|P32398 hypothetical transcriptional regulator (191 aa), FASTA scores: opt: 149,E(): 0.0014, (21.5% identity in 158 aa overlap). Also similar to MTV030_11 from Mycobacterium tuberculosis. Contains PS01081 Bacterial regulatory proteins, TetR family signature, and probable helix-turn helix motif from aa 33-54 (Score 1142, +3.08 SD). Belongs to the TetR/AcrR family of transcriptional regulators. | 0.806 |
Rv1111c | Rv1115 | Rv1111c | Rv1115 | Rv1111c, (MTV017.64c), len: 327 aa. Conserved hypothetical protein, N-terminal domain is hydrophobic,C-terminal half is very rich in Arg. Equivalent to AL049491|MLCB1222_2 hypothetical protein from Mycobacterium leprae (379 aa) (46.0% identity in 374 aa overlap). Start changed since first submission. A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al.,2004). | Possible exported protein; Rv1115, (MTCY22G8.04), len: 232 aa. Possible exported protein, contains possible N-terminal signal sequence. | 0.902 |
Rv1111c | eccC4 | Rv1111c | Rv3447c | Rv1111c, (MTV017.64c), len: 327 aa. Conserved hypothetical protein, N-terminal domain is hydrophobic,C-terminal half is very rich in Arg. Equivalent to AL049491|MLCB1222_2 hypothetical protein from Mycobacterium leprae (379 aa) (46.0% identity in 374 aa overlap). Start changed since first submission. A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al.,2004). | Rv3447c, (MTCY77.19c), len: 1236 aa. EccC4, esx conserved component, ESX-4 type VII secretion system protein, probable membrane protein, similar to various bacterial proteins e.g. O86653|SC3C3.20c ATP/GTP binding protein from Streptomyces coelicolor (1321 aa), FASTA scores: opt: 1186, E(): 1.9e-60, (42.9% identity in 1312 aa overlap); Q9L0T6|SCD35.15c from Streptomyces coelicolor (1525 aa), FASTA scores: opt: 932, E(): 9.2e-46, (27.2% identity in 1374 aa overlap); Q9CD30|ML2535 hypothetical protein from Mycobacterium leprae (1329 aa), FASTA scores: opt: 910, E(): 1.5e-44, (34.4% identi [...] | 0.656 |
Rv1111c | pimF | Rv1111c | Rv1500 | Rv1111c, (MTV017.64c), len: 327 aa. Conserved hypothetical protein, N-terminal domain is hydrophobic,C-terminal half is very rich in Arg. Equivalent to AL049491|MLCB1222_2 hypothetical protein from Mycobacterium leprae (379 aa) (46.0% identity in 374 aa overlap). Start changed since first submission. A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al.,2004). | Probable glycosyltransferase; May play only a redundant role in maintaining cell wall viability and bacterial virulence. | 0.489 |
Rv1115 | PE9 | Rv1115 | Rv1088 | Possible exported protein; Rv1115, (MTCY22G8.04), len: 232 aa. Possible exported protein, contains possible N-terminal signal sequence. | PE family protein PE9; Together with PE10, induces macrophage apoptosis through human Toll-like receptor 4 (TLR4) signaling pathway. Interaction with TLR4 leads to increased levels of phospho-IRF-3, increase in the transcript levels of IFN-beta and pro-apoptotic genes, up-regulation of IL-10, down-regulation of IL-1b and enhanced levels of macrophage apoptosis. | 0.651 |
Rv1115 | PE_PGRS25 | Rv1115 | Rv1396c | Possible exported protein; Rv1115, (MTCY22G8.04), len: 232 aa. Possible exported protein, contains possible N-terminal signal sequence. | PE-PGRS family protein PE_PGRS25; Rv1396c, (MTCY21B4.13c), len: 576 aa. PE_PGRS25,Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see Brennan & Delogu 2002),strong similarity to many e.g. glycine rich protein MTCY130.10C|E245019 (603 aa), FASTA scores: opt: 1945, E(): 0, (57.5% identity in 619 aa overlap). Contains PS00017 ATP/GTP-binding site motif A, similar to other PGRS-type sequences. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007). | 0.652 |
Rv1115 | Rv0104 | Rv1115 | Rv0104 | Possible exported protein; Rv1115, (MTCY22G8.04), len: 232 aa. Possible exported protein, contains possible N-terminal signal sequence. | Rv0104, (MTCY251.23), len: 504 aa. Conserved hypothetical protein, showing weak similarity with other cAMP-dependent protein kinases e.g. AAC37564.1|M65066 cAMP-dependent protein kinase RI-beta regulatory subunit from Homo sapiens (380 aa); etc. | 0.803 |
Rv1115 | Rv0232 | Rv1115 | Rv0232 | Possible exported protein; Rv1115, (MTCY22G8.04), len: 232 aa. Possible exported protein, contains possible N-terminal signal sequence. | Rv0232, (MTCY08D5.28), len: 229 aa. Probable transcriptional regulatory protein, TetR/AcrR family,similar to others e.g. YIXD_BACSU|P32398 hypothetical transcriptional regulator (191 aa), FASTA scores: opt: 149,E(): 0.0014, (21.5% identity in 158 aa overlap). Also similar to MTV030_11 from Mycobacterium tuberculosis. Contains PS01081 Bacterial regulatory proteins, TetR family signature, and probable helix-turn helix motif from aa 33-54 (Score 1142, +3.08 SD). Belongs to the TetR/AcrR family of transcriptional regulators. | 0.627 |
Rv1115 | Rv1111c | Rv1115 | Rv1111c | Possible exported protein; Rv1115, (MTCY22G8.04), len: 232 aa. Possible exported protein, contains possible N-terminal signal sequence. | Rv1111c, (MTV017.64c), len: 327 aa. Conserved hypothetical protein, N-terminal domain is hydrophobic,C-terminal half is very rich in Arg. Equivalent to AL049491|MLCB1222_2 hypothetical protein from Mycobacterium leprae (379 aa) (46.0% identity in 374 aa overlap). Start changed since first submission. A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al.,2004). | 0.902 |
Rv1115 | Rv1116 | Rv1115 | Rv1116 | Possible exported protein; Rv1115, (MTCY22G8.04), len: 232 aa. Possible exported protein, contains possible N-terminal signal sequence. | Hypothetical protein; Rv1116, (MTCY22G8.05), len: 61 aa. Hypothetical unknown protein. | 0.515 |
Rv1115 | Rv2190c | Rv1115 | Rv2190c | Possible exported protein; Rv1115, (MTCY22G8.04), len: 232 aa. Possible exported protein, contains possible N-terminal signal sequence. | Conserved hypothetical protein; Rv2190c, (MTV021.23c, MTCY190.01c), len: 385 aa. Conserved hypothetical protein; similar to other hypothetical mycobacterial proteins, including Rv1477,Rv1478, Rv1566c, Rv0024, that are similar to protein p60 precursors from Listeria e.g. Q018 38|P60_LISSE protein p60 precursor (invasion-associated protein) (524 aa). FASTA scores: gp|Z80233|MTCY10H4_25 (281 aa) opt: 290, E(): 6.9e-05; 37.0% identity in 127 aa overlap and sp|Q01838|P60_LISSE protein P60 precursor (523 aa) opt: 268, E(): 0.00071; 38.5% identity in 104 aa overlap; Belongs to the peptidase C [...] | 0.532 |