node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rv0004 | gnd2 | Rv0004 | Rv1122 | Rv0004, (MTCY10H4.02), len: 187 aa. Conserved hypothetical protein (see Salazar et al., 1996). Belongs to superfamily DUF721; this family contains several actinomycete proteins of unknown function. | Rv1122, (MTCY22G8.11), len: 340 aa. Probable gnd2,6-phosphogluconate dehydrogenase, decarboxylating, highly similar to Q53917 6-phosphogluconate dehydrogenase from Streptomyces coelicolor (291 aa), fasta scores: opt: 431,E(): 2.2e-20, (44.5% identity in 335 aa overlap). Also similar to Rv1844c|MTCY359.29|gnd1 probable 6-phosphogluconate dehydrogenase from Mycobacterium tuberculosis (485 aa), FASTA score: (33.0% identity in 351 aa overlap). Note that Rv1844c|MTCY359.29|gnd1 is most similar to gnd's from Gram negative organisms, while gnd2 is most similar to gnd's from Gram positive orga [...] | 0.708 |
Rv1518 | Rv3673c | Rv1518 | Rv3673c | Conserved hypothetical protein; Rv1518, (MTCY277.40, MTCY19G5.11c), len: 319 aa. Conserved hypothetical protein, possibly glycosyl transferase involved in exopolysaccharide synthesis,similar to several hypothetical proteins and glycosyl transferases from diverse organisms e.g. P73996|D90911 from synecho cystis sp. (309 aa), Fasta scores: opt: 300, E(): 1.8e-13, (29.5% identity in 241 aa overlap). | Rv3673c, (MTV025.021c), len: 227 aa. Possible membrane protein, thioredoxin-like protein (thiol-disulfide interchange protein), equivalent to Q9CB93|ML2300 putative membrane protein from Mycobacterium leprae (215 aa), FASTA scores: opt: 978, E(): 2.5e-52, (71.15% identity in 215 aa overlap). Some similarity with thioredoxin-related proteins e.g. P35160|RESA_BACSU RESA protein from Bacillus subtilis (181 aa), FASTA scores: opt: 212, E(): 5.7e-06, (30.55% identity in 108 aa overlap); Q9RXW6|DR0189 thiol:disulfide interchange protein from Deinococcus radiodurans (185 aa) FASTA scores: opt [...] | 0.656 |
Rv1518 | gnd2 | Rv1518 | Rv1122 | Conserved hypothetical protein; Rv1518, (MTCY277.40, MTCY19G5.11c), len: 319 aa. Conserved hypothetical protein, possibly glycosyl transferase involved in exopolysaccharide synthesis,similar to several hypothetical proteins and glycosyl transferases from diverse organisms e.g. P73996|D90911 from synecho cystis sp. (309 aa), Fasta scores: opt: 300, E(): 1.8e-13, (29.5% identity in 241 aa overlap). | Rv1122, (MTCY22G8.11), len: 340 aa. Probable gnd2,6-phosphogluconate dehydrogenase, decarboxylating, highly similar to Q53917 6-phosphogluconate dehydrogenase from Streptomyces coelicolor (291 aa), fasta scores: opt: 431,E(): 2.2e-20, (44.5% identity in 335 aa overlap). Also similar to Rv1844c|MTCY359.29|gnd1 probable 6-phosphogluconate dehydrogenase from Mycobacterium tuberculosis (485 aa), FASTA score: (33.0% identity in 351 aa overlap). Note that Rv1844c|MTCY359.29|gnd1 is most similar to gnd's from Gram negative organisms, while gnd2 is most similar to gnd's from Gram positive orga [...] | 0.805 |
Rv1518 | pks18 | Rv1518 | Rv1372 | Conserved hypothetical protein; Rv1518, (MTCY277.40, MTCY19G5.11c), len: 319 aa. Conserved hypothetical protein, possibly glycosyl transferase involved in exopolysaccharide synthesis,similar to several hypothetical proteins and glycosyl transferases from diverse organisms e.g. P73996|D90911 from synecho cystis sp. (309 aa), Fasta scores: opt: 300, E(): 1.8e-13, (29.5% identity in 241 aa overlap). | Conserved hypothetical protein; Involved in the biosynthesis of tri- and tetraketide alpha- pyrones. Pks18 catalyzes the extension of medium- and long-chain aliphatic acyl-CoA substrates by using malonyl-CoA as an extender molecule to synthesize polyketide products. Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family. | 0.805 |
Rv3673c | Rv1518 | Rv3673c | Rv1518 | Rv3673c, (MTV025.021c), len: 227 aa. Possible membrane protein, thioredoxin-like protein (thiol-disulfide interchange protein), equivalent to Q9CB93|ML2300 putative membrane protein from Mycobacterium leprae (215 aa), FASTA scores: opt: 978, E(): 2.5e-52, (71.15% identity in 215 aa overlap). Some similarity with thioredoxin-related proteins e.g. P35160|RESA_BACSU RESA protein from Bacillus subtilis (181 aa), FASTA scores: opt: 212, E(): 5.7e-06, (30.55% identity in 108 aa overlap); Q9RXW6|DR0189 thiol:disulfide interchange protein from Deinococcus radiodurans (185 aa) FASTA scores: opt [...] | Conserved hypothetical protein; Rv1518, (MTCY277.40, MTCY19G5.11c), len: 319 aa. Conserved hypothetical protein, possibly glycosyl transferase involved in exopolysaccharide synthesis,similar to several hypothetical proteins and glycosyl transferases from diverse organisms e.g. P73996|D90911 from synecho cystis sp. (309 aa), Fasta scores: opt: 300, E(): 1.8e-13, (29.5% identity in 241 aa overlap). | 0.656 |
Rv3673c | gnd2 | Rv3673c | Rv1122 | Rv3673c, (MTV025.021c), len: 227 aa. Possible membrane protein, thioredoxin-like protein (thiol-disulfide interchange protein), equivalent to Q9CB93|ML2300 putative membrane protein from Mycobacterium leprae (215 aa), FASTA scores: opt: 978, E(): 2.5e-52, (71.15% identity in 215 aa overlap). Some similarity with thioredoxin-related proteins e.g. P35160|RESA_BACSU RESA protein from Bacillus subtilis (181 aa), FASTA scores: opt: 212, E(): 5.7e-06, (30.55% identity in 108 aa overlap); Q9RXW6|DR0189 thiol:disulfide interchange protein from Deinococcus radiodurans (185 aa) FASTA scores: opt [...] | Rv1122, (MTCY22G8.11), len: 340 aa. Probable gnd2,6-phosphogluconate dehydrogenase, decarboxylating, highly similar to Q53917 6-phosphogluconate dehydrogenase from Streptomyces coelicolor (291 aa), fasta scores: opt: 431,E(): 2.2e-20, (44.5% identity in 335 aa overlap). Also similar to Rv1844c|MTCY359.29|gnd1 probable 6-phosphogluconate dehydrogenase from Mycobacterium tuberculosis (485 aa), FASTA score: (33.0% identity in 351 aa overlap). Note that Rv1844c|MTCY359.29|gnd1 is most similar to gnd's from Gram negative organisms, while gnd2 is most similar to gnd's from Gram positive orga [...] | 0.662 |
Rv3673c | pks18 | Rv3673c | Rv1372 | Rv3673c, (MTV025.021c), len: 227 aa. Possible membrane protein, thioredoxin-like protein (thiol-disulfide interchange protein), equivalent to Q9CB93|ML2300 putative membrane protein from Mycobacterium leprae (215 aa), FASTA scores: opt: 978, E(): 2.5e-52, (71.15% identity in 215 aa overlap). Some similarity with thioredoxin-related proteins e.g. P35160|RESA_BACSU RESA protein from Bacillus subtilis (181 aa), FASTA scores: opt: 212, E(): 5.7e-06, (30.55% identity in 108 aa overlap); Q9RXW6|DR0189 thiol:disulfide interchange protein from Deinococcus radiodurans (185 aa) FASTA scores: opt [...] | Conserved hypothetical protein; Involved in the biosynthesis of tri- and tetraketide alpha- pyrones. Pks18 catalyzes the extension of medium- and long-chain aliphatic acyl-CoA substrates by using malonyl-CoA as an extender molecule to synthesize polyketide products. Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family. | 0.585 |
devB | gnd1 | Rv1445c | Rv1844c | Probable 6-phosphogluconolactonase DevB (6PGL); Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. | Probable 6-phosphogluconate dehydrogenase Gnd1; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. | 0.958 |
devB | gnd2 | Rv1445c | Rv1122 | Probable 6-phosphogluconolactonase DevB (6PGL); Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. | Rv1122, (MTCY22G8.11), len: 340 aa. Probable gnd2,6-phosphogluconate dehydrogenase, decarboxylating, highly similar to Q53917 6-phosphogluconate dehydrogenase from Streptomyces coelicolor (291 aa), fasta scores: opt: 431,E(): 2.2e-20, (44.5% identity in 335 aa overlap). Also similar to Rv1844c|MTCY359.29|gnd1 probable 6-phosphogluconate dehydrogenase from Mycobacterium tuberculosis (485 aa), FASTA score: (33.0% identity in 351 aa overlap). Note that Rv1844c|MTCY359.29|gnd1 is most similar to gnd's from Gram negative organisms, while gnd2 is most similar to gnd's from Gram positive orga [...] | 0.964 |
devB | rpiB | Rv1445c | Rv2465c | Probable 6-phosphogluconolactonase DevB (6PGL); Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. | Ribose-5-phosphate isomerase; Catalyzes the interconversion of ribulose-5-P and ribose-5-P. It has not isomerase activity towards D-allose 6-phosphate. | 0.580 |
devB | zwf1 | Rv1445c | Rv1121 | Probable 6-phosphogluconolactonase DevB (6PGL); Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. | Probable glucose-6-phosphate 1-dehydrogenase Zwf1 (G6PD); Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. | 0.999 |
devB | zwf2 | Rv1445c | Rv1447c | Probable 6-phosphogluconolactonase DevB (6PGL); Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. | Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD); Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. | 0.999 |
gnd1 | devB | Rv1844c | Rv1445c | Probable 6-phosphogluconate dehydrogenase Gnd1; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. | Probable 6-phosphogluconolactonase DevB (6PGL); Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. | 0.958 |
gnd1 | gnd2 | Rv1844c | Rv1122 | Probable 6-phosphogluconate dehydrogenase Gnd1; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. | Rv1122, (MTCY22G8.11), len: 340 aa. Probable gnd2,6-phosphogluconate dehydrogenase, decarboxylating, highly similar to Q53917 6-phosphogluconate dehydrogenase from Streptomyces coelicolor (291 aa), fasta scores: opt: 431,E(): 2.2e-20, (44.5% identity in 335 aa overlap). Also similar to Rv1844c|MTCY359.29|gnd1 probable 6-phosphogluconate dehydrogenase from Mycobacterium tuberculosis (485 aa), FASTA score: (33.0% identity in 351 aa overlap). Note that Rv1844c|MTCY359.29|gnd1 is most similar to gnd's from Gram negative organisms, while gnd2 is most similar to gnd's from Gram positive orga [...] | 0.916 |
gnd1 | rpe | Rv1844c | Rv1408 | Probable 6-phosphogluconate dehydrogenase Gnd1; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. | Probable ribulose-phosphate 3-epimerase Rpe (PPE) (R5P3E) (pentose-5-phosphate 3-epimerase); Catalyzes the reversible epimerization of D-ribulose 5- phosphate to D-xylulose 5-phosphate; Belongs to the ribulose-phosphate 3-epimerase family. | 0.951 |
gnd1 | rpiB | Rv1844c | Rv2465c | Probable 6-phosphogluconate dehydrogenase Gnd1; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. | Ribose-5-phosphate isomerase; Catalyzes the interconversion of ribulose-5-P and ribose-5-P. It has not isomerase activity towards D-allose 6-phosphate. | 0.919 |
gnd1 | zwf1 | Rv1844c | Rv1121 | Probable 6-phosphogluconate dehydrogenase Gnd1; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. | Probable glucose-6-phosphate 1-dehydrogenase Zwf1 (G6PD); Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. | 0.973 |
gnd1 | zwf2 | Rv1844c | Rv1447c | Probable 6-phosphogluconate dehydrogenase Gnd1; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. | Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD); Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. | 0.962 |
gnd2 | Rv0004 | Rv1122 | Rv0004 | Rv1122, (MTCY22G8.11), len: 340 aa. Probable gnd2,6-phosphogluconate dehydrogenase, decarboxylating, highly similar to Q53917 6-phosphogluconate dehydrogenase from Streptomyces coelicolor (291 aa), fasta scores: opt: 431,E(): 2.2e-20, (44.5% identity in 335 aa overlap). Also similar to Rv1844c|MTCY359.29|gnd1 probable 6-phosphogluconate dehydrogenase from Mycobacterium tuberculosis (485 aa), FASTA score: (33.0% identity in 351 aa overlap). Note that Rv1844c|MTCY359.29|gnd1 is most similar to gnd's from Gram negative organisms, while gnd2 is most similar to gnd's from Gram positive orga [...] | Rv0004, (MTCY10H4.02), len: 187 aa. Conserved hypothetical protein (see Salazar et al., 1996). Belongs to superfamily DUF721; this family contains several actinomycete proteins of unknown function. | 0.708 |
gnd2 | Rv1518 | Rv1122 | Rv1518 | Rv1122, (MTCY22G8.11), len: 340 aa. Probable gnd2,6-phosphogluconate dehydrogenase, decarboxylating, highly similar to Q53917 6-phosphogluconate dehydrogenase from Streptomyces coelicolor (291 aa), fasta scores: opt: 431,E(): 2.2e-20, (44.5% identity in 335 aa overlap). Also similar to Rv1844c|MTCY359.29|gnd1 probable 6-phosphogluconate dehydrogenase from Mycobacterium tuberculosis (485 aa), FASTA score: (33.0% identity in 351 aa overlap). Note that Rv1844c|MTCY359.29|gnd1 is most similar to gnd's from Gram negative organisms, while gnd2 is most similar to gnd's from Gram positive orga [...] | Conserved hypothetical protein; Rv1518, (MTCY277.40, MTCY19G5.11c), len: 319 aa. Conserved hypothetical protein, possibly glycosyl transferase involved in exopolysaccharide synthesis,similar to several hypothetical proteins and glycosyl transferases from diverse organisms e.g. P73996|D90911 from synecho cystis sp. (309 aa), Fasta scores: opt: 300, E(): 1.8e-13, (29.5% identity in 241 aa overlap). | 0.805 |