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Rv1140 Rv1140 Rv1375 Rv1375 Rv1765c Rv1765c Rv2015c Rv2015c Rv1747 Rv1747 accD3 accD3 fbiB fbiB acg acg Rv3127 Rv3127 Rv3131 Rv3131 Rv3368c Rv3368c
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
Rv1140Rv1140, (MTCI65.07), len: 282 aa. Probable integral membrane protein. Weak similarity in C-terminus to hypothetical Escherichia coli proteins YPRA and YPRB,possibly membrane-bound e.g. YPRA_ECOLI hypothetical 24.3 kDa protein (URF 1) (217 aa), FASTA scores: opt: 166, E(): 0.00062, (31.0% identity in 158 aa overlap). (282 aa)    
Predicted Functional Partners:
Rv1375
Rv1375, (MTCY02B12.09), len: 439 aa. Conserved hypothetical protein, similar to hypothetical proteins from several organisms e.g. Q52871|U39409 Rhizobium leguminosarum (420 aa), FASTA scores: E(): 2e-30, (34.4% identity in 378 aa overlap). Predicted to be an outer membrane protein (See Song et al., 2008).
  
  
 0.654
Rv1765c
Rv1765c, (MTCY28.31c), len: 365 aa. Conserved hypothetical protein, highly similar to O53461|Rv2015c|MTV018.02c conserved hypothetical protein (418 aa), (97.8% identity in 364 aa overlap). Blast hits with non-is part of sequence submitted under MTU78639.
 
     0.552
Rv2015c
Rv2015c, (MTV018.02c), len: 418 aa. Conserved hypothetical protein. Nearly identical to Mycobacterium tuberculosis Rv1765c|MTCY28.31c, (378 aa), an ORF starting next to ISB9, and ending in IS6110. Different N-terminus chosen and C-terminus differs as that of Rv1765c has been truncated by IS6110. Does not show similarities with transposases. Contains IPR002711 HNH endonuclease,IPR003615 HNH nuclease, IPR003870 DUF222 domains.
 
     0.528
Rv1747
Probable conserved transmembrane ATP-binding protein ABC transporter; Involved in the translocation of an unknown substrate across the membrane. Transmembrane domains (TMD) form a pore in the membrane and the ATP-binding domain (NBD) is responsible for energy generation. Required for virulence; In the C-terminal section; belongs to the ABC-2 integral membrane protein family.
  
  
 0.523
accD3
Putative acetyl-coenzyme A carboxylase carboxyl transferase subunit beta; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA; Belongs to the AccD/PCCB family.
 
    0.506
fbiB
Probable F420 biosynthesis protein FbiB; Bifunctional enzyme that catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives, and the FMNH2- dependent reduction of dehydro-F420-0 to form F420-0.
  
  
 0.441
acg
Conserved protein Acg; Rv2032, (MTV018.19), len: 331 aa. Acg (for acr-coregulated gene), conserved protein possibly member of a superfamily of classical nitroreductases (see Purkayastha et al., 2002), similar to Rv3127 and Rv3131. Predicted possible vaccine candidate (See Zvi et al., 2008); Belongs to the nitroreductase family.
  
  
 0.440
Rv3127
Conserved protein; Rv3127, (MTCY164.37), len: 344 aa. Conserved protein, highly similar to Mycobacterium tuberculosis protein O53476|Rv2032|MTV018.19 (331 aa), FASTA scores: opt: 1212, E(): 6e-69, (56.7% identity in 321 aa overlap),and also similar to P95195|MTCY03A2.27c (332 aa), FASTA scores: opt: 521, E(): 1.6e-25; (35.0% identity in 326 aa overlap). Some similarity to C-terminal half of hypothetical Mycobacterium tuberculosis proteins. Predicted possible vaccine candidate (See Zvi et al., 2008).
  
  
 0.440
Rv3131
Conserved protein; Stimulates pro-inflammatory cytokine expression via TLR2 signaling pathway. Activation of TLR2 results in the phosphorylation and activation of NF-kappa-B. Also induces TLR2 expression. May influence the innate immune responses to facilitate the survival of M.tuberculosis in the granulomatous microenvironment. Belongs to the nitroreductase family.
  
  
 0.439
Rv3368c
Rv3368c, (MTV004.26c), len: 214 aa. Possible oxidoreductase, equivalent to O07697|MLCL383.23|ML0418 hypothetical 23.6 KDA protein (putative oxidoreductase) from Mycobacterium leprae (210 aa), FASTA scores: opt: 1215, E(): 1.5e-74, (81.4% identity in 210 aa overlap). Also similar to O30106|AF0131 putative NAD(P)H-flavin oxidoreductase from Archaeoglobus fulgidus (194 aa), FASTA scores: opt: 139, E(): 0.028, (29.0% identity in 207 aa overlap); Q60049|NOX_THETH NADH dehydrogenase from Thermus aquaticus (subsp. thermophilus) (205 aa), FASTA scores: opt: 169, E(): 0.00028, (28.3% identity i [...]
  
  
 0.439
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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