node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PPE23 | Rv0187 | Rv1706c | Rv0187 | Rv1706c, (MTCI125.28c), len: 394 aa. PPE23, Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, similar to many e.g. YX23_MYCTU|Q10813 hypothetical 41.1 kDa protein cy274.23 (404 aa), fasta scores: opt: 841, E(): 3.9e-31, (46.8% identity in 408 aa overlap). | Probable O-methyltransferase; Catechol O-methyltransferase that can use various catechol- like compounds such as gallic acid (GA), 3,4-dihydroxy-5-methoxy- benzoic acid (5OMeBA), protocatechuic acid (PCA), 3,4-dihydroxy- benzaldehyde (DHA), dopamine, caffeic acid (CA), luteolin, quercetin, and 5-hydroxyuridine; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. | 0.547 |
PPE23 | Rv1147 | Rv1706c | Rv1147 | Rv1706c, (MTCI125.28c), len: 394 aa. PPE23, Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, similar to many e.g. YX23_MYCTU|Q10813 hypothetical 41.1 kDa protein cy274.23 (404 aa), fasta scores: opt: 841, E(): 3.9e-31, (46.8% identity in 408 aa overlap). | Conserved protein; Rv1147, (MTCI65.14), len: 216 aa. Conserved protein,similar to many conserved hypothetical proteins, and some similarity to several methyltransferases e.g. Q05197|PMTA_RHOSH phosphatidylethanolamine N-methyltransferase from R. sphaeroides (203 aa), FASTA scores: opt: 156, E(): 0.00073, (27.6% identity in 156 aa overlap). | 0.661 |
PPE23 | Rv1341 | Rv1706c | Rv1341 | Rv1706c, (MTCI125.28c), len: 394 aa. PPE23, Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, similar to many e.g. YX23_MYCTU|Q10813 hypothetical 41.1 kDa protein cy274.23 (404 aa), fasta scores: opt: 841, E(): 3.9e-31, (46.8% identity in 408 aa overlap). | Conserved protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.549 |
PPE23 | Rv1352 | Rv1706c | Rv1352 | Rv1706c, (MTCI125.28c), len: 394 aa. PPE23, Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, similar to many e.g. YX23_MYCTU|Q10813 hypothetical 41.1 kDa protein cy274.23 (404 aa), fasta scores: opt: 841, E(): 3.9e-31, (46.8% identity in 408 aa overlap). | Conserved protein; Rv1352, (MTCY02B10.16), len: 123 aa. Conserved protein, some similarity to Rv1906c|MTCY180.12 hypothetical protein from Mycobacterium tuberculosis (156 aa), FASTA scores: E(): 4e-05, (36.2% identity in 116 aa overlap). | 0.627 |
PPE23 | Rv1867 | Rv1706c | Rv1867 | Rv1706c, (MTCI125.28c), len: 394 aa. PPE23, Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, similar to many e.g. YX23_MYCTU|Q10813 hypothetical 41.1 kDa protein cy274.23 (404 aa), fasta scores: opt: 841, E(): 3.9e-31, (46.8% identity in 408 aa overlap). | Conserved protein; Rv1867, (MTCY359.06c), len: 494 aa. Conserved protein, some similarity to acetyl CoA synthase and to lipid carriers. FASTA best: E155295 acetyl CoA synthase (388 aa), opt: 213, E(): 4.5e-07, (23.2% identity in 423 aa overlap). | 0.437 |
PPE23 | Rv2303c | Rv1706c | Rv2303c | Rv1706c, (MTCI125.28c), len: 394 aa. PPE23, Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, similar to many e.g. YX23_MYCTU|Q10813 hypothetical 41.1 kDa protein cy274.23 (404 aa), fasta scores: opt: 841, E(): 3.9e-31, (46.8% identity in 408 aa overlap). | Rv2303c, (MTCY339.06, MT2360), len: 307 aa. Probable antibiotic-resistance protein, with some similarity to Q54229|G153373 macrotetrolide antibiotic-resistance protein (NONR) from Streptomyces griseus (347 aa) (see Plater and Robinson, 1992), FASTA scores: opt: 438, E(): 3.1e-21,(33.2% identity in 226 aa overlap); and other hypothetical proteins e.g. P95886 ORF C02006 from Sulfolobus solfataricus (269 aa), FASTA scores: opt: 252, E(): 3.5e-09, (25.5% identity in 286 aa overlap); etc. Also similar to Mycobacterium tuberculosis Rv3510c|O53555|MTV023.17. Note that the protein Q9XDF3|NONC [...] | 0.631 |
PPE23 | Rv3095 | Rv1706c | Rv3095 | Rv1706c, (MTCI125.28c), len: 394 aa. PPE23, Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, similar to many e.g. YX23_MYCTU|Q10813 hypothetical 41.1 kDa protein cy274.23 (404 aa), fasta scores: opt: 841, E(): 3.9e-31, (46.8% identity in 408 aa overlap). | Rv3095, (MTCY164.06), len: 158 aa. Possible regulatory protein, because contains possible helix-turn-helix motif at aa 39-61 (+4.83 SD). Similar to hypothetical proteins e.g. Q9I0C9|PA2713 from Pseudomonas aeruginosa (159 aa), FASTA scores: opt: 486, E(): 1.6e-25,(45.95% identity in 148 aa overlap); Q9AAF6|CC0645 from Caulobacter crescentus (188 aa), FASTA scores: opt: 479,E(): 5.3e-25, (45.75% identity in 153 aa overlap); Q9K408|2SCG61.07 from Streptomyces coelicolor (157 aa),FASTA scores: opt: 407, E(): 2.8e-20, (43.9% identity in 139 aa overlap); etc. | 0.655 |
PPE23 | adhA | Rv1706c | Rv1862 | Rv1706c, (MTCI125.28c), len: 394 aa. PPE23, Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, similar to many e.g. YX23_MYCTU|Q10813 hypothetical 41.1 kDa protein cy274.23 (404 aa), fasta scores: opt: 841, E(): 3.9e-31, (46.8% identity in 408 aa overlap). | Rv1862, (MTCY359.11), len: 346 aa. Probable adhA,alcohol dehydrogenase, similar to ADH2_BACST|P42327 alcohol dehydrogenase (339 aa), FASTA scores: opt: 630, E(): 2.4e-32 (34.4% identity in 320 aa overlap). Contains PS00059 Zinc-containing alcohol dehydrogenases signature. | 0.653 |
PPE23 | hemZ | Rv1706c | Rv1485 | Rv1706c, (MTCI125.28c), len: 394 aa. PPE23, Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, similar to many e.g. YX23_MYCTU|Q10813 hypothetical 41.1 kDa protein cy274.23 (404 aa), fasta scores: opt: 841, E(): 3.9e-31, (46.8% identity in 408 aa overlap). | Ferrochelatase HemZ (protoheme ferro-lyase) (heme synthetase); Involved in the biosynthesis of heme. Catalyzes the ferrous insertion into protoporphyrin IX to form protoheme. | 0.439 |
Rv0187 | PPE23 | Rv0187 | Rv1706c | Probable O-methyltransferase; Catechol O-methyltransferase that can use various catechol- like compounds such as gallic acid (GA), 3,4-dihydroxy-5-methoxy- benzoic acid (5OMeBA), protocatechuic acid (PCA), 3,4-dihydroxy- benzaldehyde (DHA), dopamine, caffeic acid (CA), luteolin, quercetin, and 5-hydroxyuridine; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. | Rv1706c, (MTCI125.28c), len: 394 aa. PPE23, Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, similar to many e.g. YX23_MYCTU|Q10813 hypothetical 41.1 kDa protein cy274.23 (404 aa), fasta scores: opt: 841, E(): 3.9e-31, (46.8% identity in 408 aa overlap). | 0.547 |
Rv0187 | Rv1147 | Rv0187 | Rv1147 | Probable O-methyltransferase; Catechol O-methyltransferase that can use various catechol- like compounds such as gallic acid (GA), 3,4-dihydroxy-5-methoxy- benzoic acid (5OMeBA), protocatechuic acid (PCA), 3,4-dihydroxy- benzaldehyde (DHA), dopamine, caffeic acid (CA), luteolin, quercetin, and 5-hydroxyuridine; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. | Conserved protein; Rv1147, (MTCI65.14), len: 216 aa. Conserved protein,similar to many conserved hypothetical proteins, and some similarity to several methyltransferases e.g. Q05197|PMTA_RHOSH phosphatidylethanolamine N-methyltransferase from R. sphaeroides (203 aa), FASTA scores: opt: 156, E(): 0.00073, (27.6% identity in 156 aa overlap). | 0.710 |
Rv0187 | Rv1341 | Rv0187 | Rv1341 | Probable O-methyltransferase; Catechol O-methyltransferase that can use various catechol- like compounds such as gallic acid (GA), 3,4-dihydroxy-5-methoxy- benzoic acid (5OMeBA), protocatechuic acid (PCA), 3,4-dihydroxy- benzaldehyde (DHA), dopamine, caffeic acid (CA), luteolin, quercetin, and 5-hydroxyuridine; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. | Conserved protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.561 |
Rv0187 | Rv1352 | Rv0187 | Rv1352 | Probable O-methyltransferase; Catechol O-methyltransferase that can use various catechol- like compounds such as gallic acid (GA), 3,4-dihydroxy-5-methoxy- benzoic acid (5OMeBA), protocatechuic acid (PCA), 3,4-dihydroxy- benzaldehyde (DHA), dopamine, caffeic acid (CA), luteolin, quercetin, and 5-hydroxyuridine; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. | Conserved protein; Rv1352, (MTCY02B10.16), len: 123 aa. Conserved protein, some similarity to Rv1906c|MTCY180.12 hypothetical protein from Mycobacterium tuberculosis (156 aa), FASTA scores: E(): 4e-05, (36.2% identity in 116 aa overlap). | 0.630 |
Rv0187 | Rv1867 | Rv0187 | Rv1867 | Probable O-methyltransferase; Catechol O-methyltransferase that can use various catechol- like compounds such as gallic acid (GA), 3,4-dihydroxy-5-methoxy- benzoic acid (5OMeBA), protocatechuic acid (PCA), 3,4-dihydroxy- benzaldehyde (DHA), dopamine, caffeic acid (CA), luteolin, quercetin, and 5-hydroxyuridine; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. | Conserved protein; Rv1867, (MTCY359.06c), len: 494 aa. Conserved protein, some similarity to acetyl CoA synthase and to lipid carriers. FASTA best: E155295 acetyl CoA synthase (388 aa), opt: 213, E(): 4.5e-07, (23.2% identity in 423 aa overlap). | 0.438 |
Rv0187 | Rv2303c | Rv0187 | Rv2303c | Probable O-methyltransferase; Catechol O-methyltransferase that can use various catechol- like compounds such as gallic acid (GA), 3,4-dihydroxy-5-methoxy- benzoic acid (5OMeBA), protocatechuic acid (PCA), 3,4-dihydroxy- benzaldehyde (DHA), dopamine, caffeic acid (CA), luteolin, quercetin, and 5-hydroxyuridine; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. | Rv2303c, (MTCY339.06, MT2360), len: 307 aa. Probable antibiotic-resistance protein, with some similarity to Q54229|G153373 macrotetrolide antibiotic-resistance protein (NONR) from Streptomyces griseus (347 aa) (see Plater and Robinson, 1992), FASTA scores: opt: 438, E(): 3.1e-21,(33.2% identity in 226 aa overlap); and other hypothetical proteins e.g. P95886 ORF C02006 from Sulfolobus solfataricus (269 aa), FASTA scores: opt: 252, E(): 3.5e-09, (25.5% identity in 286 aa overlap); etc. Also similar to Mycobacterium tuberculosis Rv3510c|O53555|MTV023.17. Note that the protein Q9XDF3|NONC [...] | 0.656 |
Rv0187 | Rv3095 | Rv0187 | Rv3095 | Probable O-methyltransferase; Catechol O-methyltransferase that can use various catechol- like compounds such as gallic acid (GA), 3,4-dihydroxy-5-methoxy- benzoic acid (5OMeBA), protocatechuic acid (PCA), 3,4-dihydroxy- benzaldehyde (DHA), dopamine, caffeic acid (CA), luteolin, quercetin, and 5-hydroxyuridine; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. | Rv3095, (MTCY164.06), len: 158 aa. Possible regulatory protein, because contains possible helix-turn-helix motif at aa 39-61 (+4.83 SD). Similar to hypothetical proteins e.g. Q9I0C9|PA2713 from Pseudomonas aeruginosa (159 aa), FASTA scores: opt: 486, E(): 1.6e-25,(45.95% identity in 148 aa overlap); Q9AAF6|CC0645 from Caulobacter crescentus (188 aa), FASTA scores: opt: 479,E(): 5.3e-25, (45.75% identity in 153 aa overlap); Q9K408|2SCG61.07 from Streptomyces coelicolor (157 aa),FASTA scores: opt: 407, E(): 2.8e-20, (43.9% identity in 139 aa overlap); etc. | 0.661 |
Rv0187 | adhA | Rv0187 | Rv1862 | Probable O-methyltransferase; Catechol O-methyltransferase that can use various catechol- like compounds such as gallic acid (GA), 3,4-dihydroxy-5-methoxy- benzoic acid (5OMeBA), protocatechuic acid (PCA), 3,4-dihydroxy- benzaldehyde (DHA), dopamine, caffeic acid (CA), luteolin, quercetin, and 5-hydroxyuridine; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. | Rv1862, (MTCY359.11), len: 346 aa. Probable adhA,alcohol dehydrogenase, similar to ADH2_BACST|P42327 alcohol dehydrogenase (339 aa), FASTA scores: opt: 630, E(): 2.4e-32 (34.4% identity in 320 aa overlap). Contains PS00059 Zinc-containing alcohol dehydrogenases signature. | 0.677 |
Rv0187 | hemZ | Rv0187 | Rv1485 | Probable O-methyltransferase; Catechol O-methyltransferase that can use various catechol- like compounds such as gallic acid (GA), 3,4-dihydroxy-5-methoxy- benzoic acid (5OMeBA), protocatechuic acid (PCA), 3,4-dihydroxy- benzaldehyde (DHA), dopamine, caffeic acid (CA), luteolin, quercetin, and 5-hydroxyuridine; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. | Ferrochelatase HemZ (protoheme ferro-lyase) (heme synthetase); Involved in the biosynthesis of heme. Catalyzes the ferrous insertion into protoporphyrin IX to form protoheme. | 0.443 |
Rv1147 | PPE23 | Rv1147 | Rv1706c | Conserved protein; Rv1147, (MTCI65.14), len: 216 aa. Conserved protein,similar to many conserved hypothetical proteins, and some similarity to several methyltransferases e.g. Q05197|PMTA_RHOSH phosphatidylethanolamine N-methyltransferase from R. sphaeroides (203 aa), FASTA scores: opt: 156, E(): 0.00073, (27.6% identity in 156 aa overlap). | Rv1706c, (MTCI125.28c), len: 394 aa. PPE23, Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, similar to many e.g. YX23_MYCTU|Q10813 hypothetical 41.1 kDa protein cy274.23 (404 aa), fasta scores: opt: 841, E(): 3.9e-31, (46.8% identity in 408 aa overlap). | 0.661 |
Rv1147 | Rv0187 | Rv1147 | Rv0187 | Conserved protein; Rv1147, (MTCI65.14), len: 216 aa. Conserved protein,similar to many conserved hypothetical proteins, and some similarity to several methyltransferases e.g. Q05197|PMTA_RHOSH phosphatidylethanolamine N-methyltransferase from R. sphaeroides (203 aa), FASTA scores: opt: 156, E(): 0.00073, (27.6% identity in 156 aa overlap). | Probable O-methyltransferase; Catechol O-methyltransferase that can use various catechol- like compounds such as gallic acid (GA), 3,4-dihydroxy-5-methoxy- benzoic acid (5OMeBA), protocatechuic acid (PCA), 3,4-dihydroxy- benzaldehyde (DHA), dopamine, caffeic acid (CA), luteolin, quercetin, and 5-hydroxyuridine; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. | 0.710 |