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pyrR pyrR pyrB pyrB pyrF pyrF pyrC pyrC upp upp carB carB carA carA Rv1382 Rv1382 pyrH pyrH deoA deoA deoD deoD
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second shell of interactors
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Predicted Interactions
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Score
pyrRProbable pyrimidine operon regulatory protein PyrR; Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines. (193 aa)    
Predicted Functional Partners:
pyrB
Rv1380, (MTCY02B12.14), len: 319 aa. Probable pyrB,aspartate carbamoyltransferase, similar to many e.g. PYRB_BACCL|P41008 aspartate carbamoyltransferase from Bacillus caldolyticus (308 aa), FASTA scores, opt: 639,E(): 7.3e-36, (39.5% identity in 311 aa overlap). Contains PS00097 Aspartate and ornithine carbamoyltransferases signature. Belongs to the ATCases/OTCases family.
 
 
 0.998
pyrF
Rv1385, (MTCY21B4.02), len: 274 aa. Probable pyrF,orotidine 5'-phosphate decarboxylase, identical to DCOP_MYCBO|P42610 Mycobacterium bovis (274 aa). Contains PS00156 Orotidine 5'-phosphate decarboxylase active site. Belongs to the OMP decarboxylase family.
  
 
 0.997
pyrC
Probable dihydroorotase PyrC (DHOase); Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
 
 
 0.996
upp
Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate.
     
 0.989
carB
Carbamoyl-phosphate synthase large chain; Rv1384, (MTCY02B12.18-MTCY21B4.01), len: 1115 aa. Probable carB, Carbamoyl-phosphate synthase large chain, similar to many e.g. CARB_ECOLI|P00968 E. coli (1072 aa),FASTA scores: E(): 0, (52.3% identity in 1118 aa overlap). Contains two PS00867 Carbamoyl-phosphate synthase subdomain signature 2 and PS00866 Carbamoyl-phosphatesynthase subdomain signature 1. subunit: composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
  
  
 0.982
carA
Rv1383, (MTCY02B12.17), len: 376 aa. Probable carA,Carbamoyl-phosphate synthase small chain, similar to many e.g. CARA_ECOLI|P00907 carbamoyl-phosphate synthase small chain from Escherichia coli (382 aa), FASTA scores: opt: 796, E(): 0, (45.5% identity in 382 aa overlap). Contains PS00442 Glutamine amidotransferases class-I active site. The gatase domain belongs to type-1 glutamine amidotransferases. subunit: composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
  
  
 0.972
Rv1382
Rv1382, (MTCY02B12.16), len: 165 aa. Possible exported or membrane protein, hydrophobic domain at N-terminus. Predicted to be an outer membrane protein (See Song et al., 2008).
  
  
 0.964
pyrH
Probable uridylate kinase PyrH (UK) (uridine monophosphate kinase) (UMP kinase); Catalyzes the reversible phosphorylation of UMP to UDP.
  
 
 0.935
deoA
Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase); The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.
   
 
 0.913
deoD
Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP); The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Cleaves guanosine, inosine, 2'-deoxyguanosine and 2'-deoxyinosine.
  
 
 0.905
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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