Rv1921c, (MTCY09F9.43-MTV050.05c), len: 423 aa. Probable lppF, conserved lipoprotein, similar to G403173 lipoprotein precursor (fragment) from Rhodococcus erythropolis (225 aa), fasta scores: opt: 364, E(): 9.2e-19, (41.9% identity in 148 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site.

Conserved protein; Rv1754c, (MTCY28.17c), len: 563 aa. Conserved protein, has proline-rich central region. Some similarity in central region to other Mycobacterium tuberculosis proline-rich proteins e.g. O06555|Rv1157c|MTCI65.24c (371 aa), (32.5% identity in 191 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004).

Possible lipoprotein LprI; Strongly binds and inhibits lysozyme, may help bacteria survive in lysozyme-producing host cells. When overexpressed in M.tuberculosis or M.smegmatis increases resistance to hen egg white lysozyme. M.smegmatis overexpressing LprI survive better during intracellular infection of peritoneal and monocyte-derived macrophages, both of which produce lysozyme during infection; M.smegmatis does not encode this protein. Somewhat better survival is seen in human cell lines when M.smegmatis cells express both proteins from this operon, i.e. GlbN (HbN) and LprI; In the C [...]

ESX-1 secretion-associated protein EspK. Alanine and proline rich protein; May act as a chaperone that facilitates EspB secretion through an interaction with EccCb1.

ESX conserved component EccE1. ESX-1 type VII secretion system protein. Possible membrane protein; Part of the ESX-1 specialized secretion system, which delivers several virulence factors to host cells during infection, including the key virulence factors EsxA (ESAT-6) and EsxB (CFP-10). Belongs to the EccE family.

6 kDa early secretory antigenic target EsxA (ESAT-6); A secreted protein that plays a number of roles in modulating the host's immune response to infection as well as being responsible for bacterial escape into the host cytoplasm. Acts as a strong host (human) T-cell antigen. Inhibits IL- 12 p40 (IL12B) and TNF-alpha expression by infected host (mouse) macrophages, reduces the nitric oxide response by about 75%. In mice previously exposed to the bacterium, elicits high level of IFN-gamma production by T-cells upon subsequent challenge by M.tuberculosis, in the first phase of a protecti [...]

Conserved protein; Rv1978, (MTV051.16), len: 282 aa. Conserved protein,similar to several hypothetical proteins and methyltransferases e.g. X86780|SHGCPIR.15 methyltransferase from S. hygroscopicus (211 aa), FASTA scores: opt: 151,E(): 0.0072, (30.6% identity in 121 aa overlap).

Conserved protein; Exhibits lipolytic activity with medium chain length esters as optimum substrates. In vitro, pNP-caprylate (C8) is the optimum substrate followed by pNP-capricate (C10). May modulate the cell wall lipids to favor the survival of bacteria under stress conditions.

Rv0097, (MTCY251.16), len: 289 aa. Possible oxidoreductase, equivalent to NP_302343.1|NC_002677 putative oxidoreductase from Mycobacterium leprae (289 aa). Also highly similar to BAB69377.1|AB070955 putative oxidoreductase from Streptomyces avermitilis (296 aa). Contains PS00077 Cytochrome c oxidase subunit I, copper B binding region signature.