node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rv1453 | Rv1455 | Rv1453 | Rv1455 | Rv1453, (MTCY493.01c), len: 421 aa. Possible transcriptional activator, similar to Q50018 putative transcriptional activator trx from Mycobacterium leprae (517 aa), FASTA scores: opt: 1719, E(): 0, (54.0% identity in 500 aa overlap). Also highly similar to Mycobacterium tuberculosis proteins Rv2370c, Rv1194c, Rv2242, Rv1186c,and to the further upstream ORF's Rv1429|MTCY493.25c (28.1% identity in 335 aa overlap). Start changed since first submission (-11 aa). | Conserved protein; Rv1455, (MTV007.02), len: 287 aa. Conserved protein,some similarity from aa 80-160 to Z99125|MLCL536.35c hypothetical Mycobacterium leprae protein (101 aa), FASTA scores: opt: 238, E(): 1.8e-08, (51.3% identity in 78 aa overlap). | 0.870 |
Rv1453 | lpdA | Rv1453 | Rv3303c | Rv1453, (MTCY493.01c), len: 421 aa. Possible transcriptional activator, similar to Q50018 putative transcriptional activator trx from Mycobacterium leprae (517 aa), FASTA scores: opt: 1719, E(): 0, (54.0% identity in 500 aa overlap). Also highly similar to Mycobacterium tuberculosis proteins Rv2370c, Rv1194c, Rv2242, Rv1186c,and to the further upstream ORF's Rv1429|MTCY493.25c (28.1% identity in 335 aa overlap). Start changed since first submission (-11 aa). | NAD(P)H quinone reductase LpdA; May contribute to virulence by increasing resistance to reactive oxygen intermediates. It can reduce 2,6-dimethyl-1,4- benzoquinone (DMBQ), 5-hydroxy-1,4-naphthaquinone (5-HNQ) and menadione. NADPH is the physiological reductant rather than NADH. | 0.636 |
Rv1453 | mmpR5 | Rv1453 | Rv0678 | Rv1453, (MTCY493.01c), len: 421 aa. Possible transcriptional activator, similar to Q50018 putative transcriptional activator trx from Mycobacterium leprae (517 aa), FASTA scores: opt: 1719, E(): 0, (54.0% identity in 500 aa overlap). Also highly similar to Mycobacterium tuberculosis proteins Rv2370c, Rv1194c, Rv2242, Rv1186c,and to the further upstream ORF's Rv1429|MTCY493.25c (28.1% identity in 335 aa overlap). Start changed since first submission (-11 aa). | Conserved protein; Controls the expression level of the Mmps2-MmpL2, MmpS4- MmpL4, and MmpS5-MmpL5 transport systems. Also controls its own expression. Acts by binding directly to the promoter regions. | 0.533 |
Rv1453 | qor | Rv1453 | Rv1454c | Rv1453, (MTCY493.01c), len: 421 aa. Possible transcriptional activator, similar to Q50018 putative transcriptional activator trx from Mycobacterium leprae (517 aa), FASTA scores: opt: 1719, E(): 0, (54.0% identity in 500 aa overlap). Also highly similar to Mycobacterium tuberculosis proteins Rv2370c, Rv1194c, Rv2242, Rv1186c,and to the further upstream ORF's Rv1429|MTCY493.25c (28.1% identity in 335 aa overlap). Start changed since first submission (-11 aa). | Probable quinone reductase Qor (NADPH:quinone reductase) (zeta-crystallin homolog protein); Rv1454c, (MTV007.01c), len: 328 aa. Probable qor,quinone oxidoreductase, simiar to U87282|RCU87282_2 quinone oxidoreductase from Rhodobacter capsulatus (323 aa), FASTA scores: opt: 849, E(): 0, (44.7% identity in 329 aa overlap). Also similar to MTCY180.06 Hypothetical protein from Mycobacterium tuberculosis (334 aa), FASTA scores: opt: 430, E(): 2e-14, (32.3% identity in 350 aa overlap). Contains PS01162 Quinone oxidoreductase / zeta-crystallin signature. | 0.806 |
Rv1455 | Rv1453 | Rv1455 | Rv1453 | Conserved protein; Rv1455, (MTV007.02), len: 287 aa. Conserved protein,some similarity from aa 80-160 to Z99125|MLCL536.35c hypothetical Mycobacterium leprae protein (101 aa), FASTA scores: opt: 238, E(): 1.8e-08, (51.3% identity in 78 aa overlap). | Rv1453, (MTCY493.01c), len: 421 aa. Possible transcriptional activator, similar to Q50018 putative transcriptional activator trx from Mycobacterium leprae (517 aa), FASTA scores: opt: 1719, E(): 0, (54.0% identity in 500 aa overlap). Also highly similar to Mycobacterium tuberculosis proteins Rv2370c, Rv1194c, Rv2242, Rv1186c,and to the further upstream ORF's Rv1429|MTCY493.25c (28.1% identity in 335 aa overlap). Start changed since first submission (-11 aa). | 0.870 |
Rv1455 | Rv1987 | Rv1455 | Rv1987 | Conserved protein; Rv1455, (MTV007.02), len: 287 aa. Conserved protein,some similarity from aa 80-160 to Z99125|MLCL536.35c hypothetical Mycobacterium leprae protein (101 aa), FASTA scores: opt: 238, E(): 1.8e-08, (51.3% identity in 78 aa overlap). | Possible chitinase; Rv1987, (MTCY39.32c), len: 142 aa. Possible chitinase, similar to several e.g. P36909|CHIT_STRLI chitinase c precursor (619 aa) FASTA scores, opt: 324, E(): 1.2e-14, (39.5% identity in 129 aa overlap). | 0.443 |
Rv1455 | Rv2672 | Rv1455 | Rv2672 | Conserved protein; Rv1455, (MTV007.02), len: 287 aa. Conserved protein,some similarity from aa 80-160 to Z99125|MLCL536.35c hypothetical Mycobacterium leprae protein (101 aa), FASTA scores: opt: 238, E(): 1.8e-08, (51.3% identity in 78 aa overlap). | Rv2672, (MTCY441.41), len: 528 aa. Possible secreted protease, equivalent to O05685|MLC1351.24|ML1339 putative secreted protease from Mycobacterium leprae (525 aa), FASTA scores: opt: 2722, E(): 9.4e-140, (74.45% identity in 528 aa overlap). Also similar to several exported proteinases from Streptomyces and Mycobacteria e.g. Q54399|SLPE proteinase from Streptomyces lividans (513 aa), FASTA scores: opt: 429, E(): 6.8e-16, (26.2% identity in 538 aa overlap); Q9FCK9|2SC3B6.03c peptidase from Streptomyces coelicolor (513 aa), FASTA scores: opt: 421, E(): 1.8e-15,(26.45% identity in 541 aa [...] | 0.400 |
Rv1455 | lpdA | Rv1455 | Rv3303c | Conserved protein; Rv1455, (MTV007.02), len: 287 aa. Conserved protein,some similarity from aa 80-160 to Z99125|MLCL536.35c hypothetical Mycobacterium leprae protein (101 aa), FASTA scores: opt: 238, E(): 1.8e-08, (51.3% identity in 78 aa overlap). | NAD(P)H quinone reductase LpdA; May contribute to virulence by increasing resistance to reactive oxygen intermediates. It can reduce 2,6-dimethyl-1,4- benzoquinone (DMBQ), 5-hydroxy-1,4-naphthaquinone (5-HNQ) and menadione. NADPH is the physiological reductant rather than NADH. | 0.685 |
Rv1455 | lpqF | Rv1455 | Rv3593 | Conserved protein; Rv1455, (MTV007.02), len: 287 aa. Conserved protein,some similarity from aa 80-160 to Z99125|MLCL536.35c hypothetical Mycobacterium leprae protein (101 aa), FASTA scores: opt: 238, E(): 1.8e-08, (51.3% identity in 78 aa overlap). | Rv3593, (MTCY6F7.01c), len: 452 aa. Probable lpqF,conserved lipoprotein, equivalent to Q9CBI7|MPQF|ML1923 probale secreted protein from Mycobacterium leprae (454 aa), FASTA scores: opt: 2465, E(): 5.7e-144, (79.15% identity in 451 aa overlap). Also similar to Q9KJ91 hypothetical 47.1 KDA protein from Streptomyces clavuligerus (430 aa), FASTA scores: opt: 609, E(): 5.2e-30, (30.3% identity in 350 aa overlap); and some similarity with putative beta-lactamases e.g. Q9RYR7|DRA0241 beta lactamase-related protein from Deinococcus radiodurans (499 aa), FASTA scores: opt: 322,E(): 2.5e-12, (28 [...] | 0.412 |
Rv1455 | mmpR5 | Rv1455 | Rv0678 | Conserved protein; Rv1455, (MTV007.02), len: 287 aa. Conserved protein,some similarity from aa 80-160 to Z99125|MLCL536.35c hypothetical Mycobacterium leprae protein (101 aa), FASTA scores: opt: 238, E(): 1.8e-08, (51.3% identity in 78 aa overlap). | Conserved protein; Controls the expression level of the Mmps2-MmpL2, MmpS4- MmpL4, and MmpS5-MmpL5 transport systems. Also controls its own expression. Acts by binding directly to the promoter regions. | 0.416 |
Rv1455 | pirG | Rv1455 | Rv3810 | Conserved protein; Rv1455, (MTV007.02), len: 287 aa. Conserved protein,some similarity from aa 80-160 to Z99125|MLCL536.35c hypothetical Mycobacterium leprae protein (101 aa), FASTA scores: opt: 238, E(): 1.8e-08, (51.3% identity in 78 aa overlap). | Exported repetitive protein precursor PirG (cell surface protein) (EXP53); Surface-exposed protein required for multiplication and intracellular growth; To M.leprae 28 kDa antigen. | 0.538 |
Rv1455 | qor | Rv1455 | Rv1454c | Conserved protein; Rv1455, (MTV007.02), len: 287 aa. Conserved protein,some similarity from aa 80-160 to Z99125|MLCL536.35c hypothetical Mycobacterium leprae protein (101 aa), FASTA scores: opt: 238, E(): 1.8e-08, (51.3% identity in 78 aa overlap). | Probable quinone reductase Qor (NADPH:quinone reductase) (zeta-crystallin homolog protein); Rv1454c, (MTV007.01c), len: 328 aa. Probable qor,quinone oxidoreductase, simiar to U87282|RCU87282_2 quinone oxidoreductase from Rhodobacter capsulatus (323 aa), FASTA scores: opt: 849, E(): 0, (44.7% identity in 329 aa overlap). Also similar to MTCY180.06 Hypothetical protein from Mycobacterium tuberculosis (334 aa), FASTA scores: opt: 430, E(): 2e-14, (32.3% identity in 350 aa overlap). Contains PS01162 Quinone oxidoreductase / zeta-crystallin signature. | 0.878 |
Rv1987 | Rv1455 | Rv1987 | Rv1455 | Possible chitinase; Rv1987, (MTCY39.32c), len: 142 aa. Possible chitinase, similar to several e.g. P36909|CHIT_STRLI chitinase c precursor (619 aa) FASTA scores, opt: 324, E(): 1.2e-14, (39.5% identity in 129 aa overlap). | Conserved protein; Rv1455, (MTV007.02), len: 287 aa. Conserved protein,some similarity from aa 80-160 to Z99125|MLCL536.35c hypothetical Mycobacterium leprae protein (101 aa), FASTA scores: opt: 238, E(): 1.8e-08, (51.3% identity in 78 aa overlap). | 0.443 |
Rv1987 | lpqF | Rv1987 | Rv3593 | Possible chitinase; Rv1987, (MTCY39.32c), len: 142 aa. Possible chitinase, similar to several e.g. P36909|CHIT_STRLI chitinase c precursor (619 aa) FASTA scores, opt: 324, E(): 1.2e-14, (39.5% identity in 129 aa overlap). | Rv3593, (MTCY6F7.01c), len: 452 aa. Probable lpqF,conserved lipoprotein, equivalent to Q9CBI7|MPQF|ML1923 probale secreted protein from Mycobacterium leprae (454 aa), FASTA scores: opt: 2465, E(): 5.7e-144, (79.15% identity in 451 aa overlap). Also similar to Q9KJ91 hypothetical 47.1 KDA protein from Streptomyces clavuligerus (430 aa), FASTA scores: opt: 609, E(): 5.2e-30, (30.3% identity in 350 aa overlap); and some similarity with putative beta-lactamases e.g. Q9RYR7|DRA0241 beta lactamase-related protein from Deinococcus radiodurans (499 aa), FASTA scores: opt: 322,E(): 2.5e-12, (28 [...] | 0.458 |
Rv1987 | pirG | Rv1987 | Rv3810 | Possible chitinase; Rv1987, (MTCY39.32c), len: 142 aa. Possible chitinase, similar to several e.g. P36909|CHIT_STRLI chitinase c precursor (619 aa) FASTA scores, opt: 324, E(): 1.2e-14, (39.5% identity in 129 aa overlap). | Exported repetitive protein precursor PirG (cell surface protein) (EXP53); Surface-exposed protein required for multiplication and intracellular growth; To M.leprae 28 kDa antigen. | 0.658 |
Rv2672 | Rv1455 | Rv2672 | Rv1455 | Rv2672, (MTCY441.41), len: 528 aa. Possible secreted protease, equivalent to O05685|MLC1351.24|ML1339 putative secreted protease from Mycobacterium leprae (525 aa), FASTA scores: opt: 2722, E(): 9.4e-140, (74.45% identity in 528 aa overlap). Also similar to several exported proteinases from Streptomyces and Mycobacteria e.g. Q54399|SLPE proteinase from Streptomyces lividans (513 aa), FASTA scores: opt: 429, E(): 6.8e-16, (26.2% identity in 538 aa overlap); Q9FCK9|2SC3B6.03c peptidase from Streptomyces coelicolor (513 aa), FASTA scores: opt: 421, E(): 1.8e-15,(26.45% identity in 541 aa [...] | Conserved protein; Rv1455, (MTV007.02), len: 287 aa. Conserved protein,some similarity from aa 80-160 to Z99125|MLCL536.35c hypothetical Mycobacterium leprae protein (101 aa), FASTA scores: opt: 238, E(): 1.8e-08, (51.3% identity in 78 aa overlap). | 0.400 |
Rv2672 | lpqF | Rv2672 | Rv3593 | Rv2672, (MTCY441.41), len: 528 aa. Possible secreted protease, equivalent to O05685|MLC1351.24|ML1339 putative secreted protease from Mycobacterium leprae (525 aa), FASTA scores: opt: 2722, E(): 9.4e-140, (74.45% identity in 528 aa overlap). Also similar to several exported proteinases from Streptomyces and Mycobacteria e.g. Q54399|SLPE proteinase from Streptomyces lividans (513 aa), FASTA scores: opt: 429, E(): 6.8e-16, (26.2% identity in 538 aa overlap); Q9FCK9|2SC3B6.03c peptidase from Streptomyces coelicolor (513 aa), FASTA scores: opt: 421, E(): 1.8e-15,(26.45% identity in 541 aa [...] | Rv3593, (MTCY6F7.01c), len: 452 aa. Probable lpqF,conserved lipoprotein, equivalent to Q9CBI7|MPQF|ML1923 probale secreted protein from Mycobacterium leprae (454 aa), FASTA scores: opt: 2465, E(): 5.7e-144, (79.15% identity in 451 aa overlap). Also similar to Q9KJ91 hypothetical 47.1 KDA protein from Streptomyces clavuligerus (430 aa), FASTA scores: opt: 609, E(): 5.2e-30, (30.3% identity in 350 aa overlap); and some similarity with putative beta-lactamases e.g. Q9RYR7|DRA0241 beta lactamase-related protein from Deinococcus radiodurans (499 aa), FASTA scores: opt: 322,E(): 2.5e-12, (28 [...] | 0.451 |
Rv2672 | pirG | Rv2672 | Rv3810 | Rv2672, (MTCY441.41), len: 528 aa. Possible secreted protease, equivalent to O05685|MLC1351.24|ML1339 putative secreted protease from Mycobacterium leprae (525 aa), FASTA scores: opt: 2722, E(): 9.4e-140, (74.45% identity in 528 aa overlap). Also similar to several exported proteinases from Streptomyces and Mycobacteria e.g. Q54399|SLPE proteinase from Streptomyces lividans (513 aa), FASTA scores: opt: 429, E(): 6.8e-16, (26.2% identity in 538 aa overlap); Q9FCK9|2SC3B6.03c peptidase from Streptomyces coelicolor (513 aa), FASTA scores: opt: 421, E(): 1.8e-15,(26.45% identity in 541 aa [...] | Exported repetitive protein precursor PirG (cell surface protein) (EXP53); Surface-exposed protein required for multiplication and intracellular growth; To M.leprae 28 kDa antigen. | 0.543 |
lpdA | Rv1453 | Rv3303c | Rv1453 | NAD(P)H quinone reductase LpdA; May contribute to virulence by increasing resistance to reactive oxygen intermediates. It can reduce 2,6-dimethyl-1,4- benzoquinone (DMBQ), 5-hydroxy-1,4-naphthaquinone (5-HNQ) and menadione. NADPH is the physiological reductant rather than NADH. | Rv1453, (MTCY493.01c), len: 421 aa. Possible transcriptional activator, similar to Q50018 putative transcriptional activator trx from Mycobacterium leprae (517 aa), FASTA scores: opt: 1719, E(): 0, (54.0% identity in 500 aa overlap). Also highly similar to Mycobacterium tuberculosis proteins Rv2370c, Rv1194c, Rv2242, Rv1186c,and to the further upstream ORF's Rv1429|MTCY493.25c (28.1% identity in 335 aa overlap). Start changed since first submission (-11 aa). | 0.636 |
lpdA | Rv1455 | Rv3303c | Rv1455 | NAD(P)H quinone reductase LpdA; May contribute to virulence by increasing resistance to reactive oxygen intermediates. It can reduce 2,6-dimethyl-1,4- benzoquinone (DMBQ), 5-hydroxy-1,4-naphthaquinone (5-HNQ) and menadione. NADPH is the physiological reductant rather than NADH. | Conserved protein; Rv1455, (MTV007.02), len: 287 aa. Conserved protein,some similarity from aa 80-160 to Z99125|MLCL536.35c hypothetical Mycobacterium leprae protein (101 aa), FASTA scores: opt: 238, E(): 1.8e-08, (51.3% identity in 78 aa overlap). | 0.685 |