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fadE15 fadE15 fadB fadB fixB fixB fixA fixA Rv0487 Rv0487 echA12 echA12 echA3 echA3 Rv3679 Rv3679 nuoI nuoI PE_PGRS29 PE_PGRS29 echA7 echA7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
fadE15Rv1467c, (MTV007.14c), len: 609 aa. Probable fadE15,acyl-CoA dehydrogenase, highly similar to NP_302639.1|NC_002677 acyl-CoA dehydrogenase from Mycobacterium leprae (611 aa). Also highly similar to many e.g. T36481 probable acyl-CoA dehydrogenase (fragment) from Streptomyces coelicolor (491 aa) (has its N-terminus very shorter); NP_384640.1|NC_003047 putative acyl-CoA dehydrogenase protein from Sinorhizobium meliloti (598 aa); ACDS_MEGEL|Q06319 acyl-CoA dehydrogenase (short-chain specific) from Megasphaera elsdenii (383 aa), FASTA scores: E(): 2e-12, (25.4% identity in 410 aa overlap); [...] (609 aa)    
Predicted Functional Partners:
fadB
Rv0860, (MTV043.53), len: 720 aa. Probable fadB,fatty oxidation protein, equivalent to NP_302422.1|NC_002677 putative fatty oxidation complex alpha subunit from Mycobacterium leprae (714 aa). Also highly similar to others and various proteins involved in fatty acid metabolism, e.g. T35429 probable fatty oxidation protein from Streptomyces coelicolor (733 aa); NP_250428.1|NC_002516 probable 3-hydroxyacyl-CoA dehydrogenase from Pseudomonas aeruginosa (714 aa); NP_418895.1|NC_002696 fatty oxidation complex alpha subunit from Caulobacter crescentus (709 aa); P40939|ECHA_HUMAN trifunctional [...]
  
 0.802
fixB
Electron transfer flavoprotein subunit alpha; The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (By similarity).
 
 
 0.783
fixA
Electron transfer flavoprotein subunit beta; The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (By similarity).
 
 
 0.741
Rv0487
Rv0487, (MTCY20G9.13), len: 183 aa. Conserved hypothetical protein, highly similar to P54139|Y487_MYCLE|U00018_38|ML2442 hypothetical 20.8 KDA protein from Mycobacterium leprae (184 aa), FASTA scores: opt: 760, E(): 2.4 e-34, (73.0% identity in 159 aa overlap). Also highly similar to CAC04041.1|AL391406 conserved hypothetical protein from Streptomyces coelicolor (168 aa); To M.leprae ML2442.
  
     0.722
echA12
Possible enoyl-CoA hydratase EchA12 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase); Could possibly oxidize fatty acids using specific components.
  
 0.684
echA3
Probable enoyl-CoA hydratase EchA3 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase); Rv0632c, (MTCY20H10.13c), len: 231 aa. Probable echA3, enoyl-CoA hydratase, almost identical to the MTU88877_1 enoyl-CoA hydratase of Mycobacterium tuberculosis field isolate NTI64719, FASTA score: (92.4% identity in 184 aa overlap). Also similar to others e.g. P24162|ECHH_RHOCA enoyl-CoA hydratase from Rhodobacter capsulatus (Rhodopseudomonas capsulata) (257 aa), FASTA scores: opt: 206, E(): 6.3e-07, (31.5% identity in 232 aa overlap); etc.
 
 0.660
Rv3679
Rv3679, (MTV025.027), len: 340 aa. Probable anion transporting ATPase, equivalent to Q9CB88|ML2305 probable anion transporter protein from Mycobacterium leprae (341 aa), FASTA scores: opt: 1810, E(): 2.1e-98, (84.15% identity in 341 aa overlap). Also highly similar to Q9XA36|SCH17.11 putative ion-transporting ATPase from Streptomyces coelicolor (325 aa), FASTA scores: opt: 989,E(): 1.4e-50, (52.15% identity in 328 aa overlap); and similar to many anion transporting ATPases (principally arsenite transporters) e.g. O50593|ARSA_ACIMU arsenical pump-driving ATPase (arsenite-translocating A [...]
  
    0.651
nuoI
Probable NADH dehydrogenase I (chain I) NuoI (NADH-ubiquinone oxidoreductase chain I); NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
  
 0.649
PE_PGRS29
PE-PGRS family protein PE_PGRS29; Rv1468c, (MTV007.15c), len: 370 aa. PE_PGRS29,Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below).
       0.648
echA7
Probable enoyl-CoA hydratase EchA7 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase); Rv0971c, (MTCY10D7.03), len: 269 aa. Probable echA7,enoyl-CoA hydratase, similar to many e.g. CAB95895.1|AL359988 putative enoyl CoA hydratase from Streptomyces coelicolor (247 aa); P24162|ECHH_RHOCA enoyl-CoA hydratase from Rhodobacter capsulatus (257 aa),FASTA scores: opt: 369, E(): 2.6e-15, (33.7% identity in 246 aa overlap); etc.
 
 0.640
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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