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Rv1489 Rv1489 Rv1488 Rv1488 pra pra Rv2563 Rv2563 Rv1487 Rv1487 Rv1486c Rv1486c Rv1489A Rv1489A Rv2585c Rv2585c lpqG lpqG Rv0072 Rv0072 Rv1490 Rv1490
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
Rv1489Rv1489, len: 118 aa. Conserved protein, similar to hypothetical proteins from Mycobacterium avium subsp. paratuberculosis and Streptomyces coelicolor e.g. AJ250017_1 insertion sequence IS900, Locus 3, putative invasion protein from M. paratuberculosis (138 aa), FASTA scores: opt: 120, E(): 0.26, (34.375% identity in 96 aa overlap); SCD6.11c|AL353815_11 possible integral membrane protein from Streptomyces coelicolor (136 aa), FASTA scores: opt: 106, E(): 2.2, (35.9% identity in 103 aa overlap). ORF predicted by GC plot. Replaces previous Rv1489c on other strand. (118 aa)    
Predicted Functional Partners:
Rv1488
Rv1488, (MTCY277.09), len: 381 aa. Possible exported conserved protein; contains possible N-terminal signal sequence. Similar to YBBK_ECOLI|P77367 hypothetical protein ybbK from Escherichia coli (305 aa), FASTA scores: opt: 716, E(): 0, (37.1% identity in 307 aa overlap). Similar to stomatin-like proteins e.g. AF065260|AF065260_1 Clostridium difficile (320 aa), FASTA scores: opt: 767, E(): 0, (42.3% identity in 307 aa overlap). Predicted to be an outer membrane protein (See Song et al., 2008).
  
    0.878
pra
Rv1078, (MTV017.31), len: 240 aa. Probable pra,Proline-rich antigen homolog, equivalent to X65546|MLPRAG_1 proline rich antigen from Mycobacterium leprae (249 aa),FASTA scores: opt: 1162, E(): 3.3e-30, (64.8% identity in 253 aa overlap). Has potential hydrophobic domains.
   
  
 0.870
Rv2563
Rv2563, (MTCY9C4.05c), len: 349 aa. Probable glutamine-transport transmembrane protein ABC transporter (see citation below), highly similar to O53617|Rv0072|MTV030.16 putative ABC-transporter transmembrane subunit from Mycobacterium tuberculosis (349 aa), FASTA scores: opt: 1772, E(): 1.1e-89, (76.2% identity in 349 aa overlap). Also some similarity with various hypothetical proteins e.g. Q9RYN1|DRA0279 hypothetical 37.1 KDA protein from Deinococcus radiodurans (353 aa), FASTA scores: opt: 347, E(): 6.6e-12, (24.35% identity in 357 aa overlap); BAB58522|SAV2360 conserved hypothetical p [...]
      
 0.870
Rv1487
Conserved membrane protein; Rv1487, (MTCY277.08), len: 144 aa. Conserved membrane protein. Highly similar to O07404|AF002133 MAV145 from Mycobacterium avium (145 aa), FASTA scores: opt: 667,E(): 0, (72.5% identity in 142 aa overlap). Also similar to AL079332|SCI5.05 hypothetical protein from Streptomyces coelicolor (143 aa), FASTA scores: opt: 344, E(): 1.3e-15,(44.8% identity in 134 aa overlap).
  
    0.853
Rv1486c
Rv1486c, (MTCY277.07c), len: 288 aa. Conserved hypothetical protein, highly similar to YS07_MYCAV|O07402 hypothetical 33.5 kDa protein mav321 from Mycobacterium avium (320 aa), FASTA scores: opt: 1217, E(): 0, (71.1% identity in 315 aa overlap). Weak similarity to AL079332|SCI5.07 hypothetical protein from Streptomyces coelicolor (259 aa), FASTA scores: opt: 131, E(): 0.29,(32.3% identity in 279 aa overlap). Start changed since original submission; To M.bovis Mb1522c, M.leprae ML1804 and M.avium MAV321.
  
    0.774
Rv1489A
Rv1489A, len: 76 aa. Conserved protein, similar to part of alpha subunit of many methylmalonyl-CoA mutases (~750 aa). Size difference suggests possible gene fragment although Mycobacterium tuberculosis has intact methylmalonyl-CoA mutase gene. P71774|MUTB_MYCTU probable methylmalonyl-CoA mutase from Mycobacterium tuberculosis (750 aa), FASTA scores: opt: 258, E(): 3.2e-10, (73.35% identity in 60 aa overlap). ORF predicted by GC plot.
  
    0.705
Rv2585c
Possible conserved lipoprotein; Rv2585c, (MT2662, MTCY227.16), len: 557 aa. Possible conserved lipoprotein precursor, possibly attached to the membrane by a lipid anchor and substrate-binding protein involved in transport, equivalent to Q49646|YP85_MYCLE|ML0489|MLCB1259.07|B1177_C2_197 hypothetical lipoprotein precursor from Mycobacterium leprae (555 aa), FASTA scores: opt: 2812, E(): 9.8e-158,(78.95% identity in 546 aa overlap); and C-terminus highly similar to C-terminus of Q49638|DCIAE|B1177_C1_166 DCIAE protein from Mycobacterium leprae (344 aa), FASTA scores: opt: 1177, E(): 7.4e- [...]
   
  
 0.658
lpqG
Rv3623, (MTCY15C10.29c), len: 240 aa. Probable lpqG,conserved lipoprotein, showing some similarity with hypothetical proteins e.g. Q57432 from Methanosarcina barkeri (251 aa), FASTA scores: opt: 319, E(): 6.8e-12,(31.2% identity in 218 aa overlap); Q9PEA5|XF1123 outer membrane protein from Xylella fastidiosa (242 aa) FASTA scores: opt: 312, E(): 1.7e-11, (28.25% identity in 237 aa overlap); BAB49547|MLR2408 hypothetical protein from Rhizobium loti (Mesorhizobium loti) (236 aa), FASTA scores: opt: 304, E(): 5e-11, (27.05% identity in 244 aa overlap); etc. Has suitable signal peptide and [...]
      
 0.519
Rv0072
Probable glutamine-transport transmembrane protein ABC transporter; Probably part of an ABC transporter complex. Probably responsible for the translocation of the substrate across the membrane (By similarity).
   
  
 0.517
Rv1490
Probable membrane protein; Rv1490, (MTCY277.12), len: 435 aa. Probable membrane protein.
  
    0.437
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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