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Rv1584c Rv1584c Rv1585c Rv1585c Rv0500A Rv0500A Rv2310 Rv2310 Rv1586c Rv1586c Rv1583c Rv1583c Rv1582c Rv1582c vapB50 vapB50 Rv1572c Rv1572c Rv0061c Rv0061c Rv1587c Rv1587c
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
Rv1584cRv1584c, (MTCY336.20), len: 73 aa. Possible phiRv1 phage protein (putative excisionase) (see citation below). This region is a possible MT-complex-specific genomic island (See Becq et al., 2007). (73 aa)    
Predicted Functional Partners:
Rv1585c
Rv1585c, (MTCY336.19), len: 171 aa. Possible phage phiRv1 protein (see Hatfull 2000). This region is a possible MT-complex-specific genomic island (See Becq et al., 2007).
  
  
 0.931
Rv0500A
Rv0500A, len: 78 aa. Conserved protein, similar to proteins from Mycobacterium leprae and Streptomyces coelicolor e.g. U00018_25 from Mycobacterium leprae cosmid B2168 (86 aa), FASTA scores: opt: 428, E(): 1.3e-27, (82.6% identity in 86 aa overlap); AL079345|SCE68_26 from Streptomyces coelicolor cosmid E6 (70 aa), FASTA scores: opt: 252, E(): 1.2 e-13, (72.2 identity in 54 aa overlap).
      
 0.870
Rv2310
Possible excisionase; Rv2310, (MT2372, MTCY3G12.24c), len: 114 aa. Possible excisionase, showing some similarity to others e.g. Q9LCU5 putative excisionase from Arthrobacter sp. TM1 (174 aa) FASTA scores: opt: 341, E(): 6.6e-15, (48.2% identity in 110 aa overlap); O85865 putative excisionase from Sphingomonas aromaticivorans (152 aa), FASTA scores: opt: 205, E(): 2.2e-06, (41.25% identity in 80 aa overlap); etc. Also similar to Rv3750c|O69717 hypothetical protein from Mycobacterium tuberculosis (130 aa), FASTA scores: opt: 228, E(): 6.9e-08, (43.9% identity in 82 aa overlap). Contains [...]
   
  
 0.870
Rv1586c
Probable PhiRv1 integrase; Rv1586c, (MTCY336.18), len: 469 aa. Probable phiRv1 integrase, possibly member of the serine family of recombinases (see citation below), similar to several bacteriophage integrases e.g. Q37839 ORF469 protein from Bacteriophage R4 (469 aa), FASTA scores: opt: 623, E(): 1.6e-29, (31.1% identity in 482 aa overlap); and Bacteriophage TP901-1. This region is a possible MT-complex-specific genomic island (See Becq et al.,2007).
  
  
 0.857
Rv1583c
Rv1583c, (MTCY336.21), len: 132 aa. Probable phiRv1 phage protein (see citation below), highly similar to Rv2656c|MTCY441.25c phiRV2 phage protein (130 aa), FASTA score: E(): 1.3e-33, (81.7% identity in 131 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et al., 2007); To M.tuberculosis Rv2656c.
  
    0.780
Rv1582c
Rv1582c, (MTCY336.22), len: 471 aa. Probable phiRv1 phage protein (see citation below). N-terminus is similar to C-terminus of Q38030 ORF9 Bacteriophage phi-C31 (519 aa), FASTA scores: opt: 331, E(): 6.5e-15, (28.5% identity in 235 aa overlap); and C-terminus to whole of Q38031 ORF10 of Bacteriophage phi-C31 (202 aa), FASTA scores: opt: 353,E(): 1e-16, (31.1% identity in 190 aa overlap). Also similar to part of AB016282|AB016282_42 Bacteriophage phi-105 (806 aa), FASTA scores: opt: 790, E(): 0, (32.7% identity in 459 aa overlap). Similarity to other phage proteins described as putative [...]
  
    0.777
vapB50
Possible excisionase; Possibly the antitoxin component of a type II toxin-antitoxin (TA) system. Its cognate toxin is VapC50.
   
  
 0.698
Rv1572c
Conserved hypothetical protein; Rv1572c, (MTCY336.31B), len: 34 aa. Partial ORF,part of REP13E12 repeat element; 3' end of Rv1587c (MTCY336.17) after phage-like element (see citation below). Similar to C-terminal ends of other REP13E12 repeat elements e.g. Rv1148, Rv1945, Rv3467, etc. Length extended since first submission (+7 aa). This region is a possible MT-complex-specific genomic island (See Becq et al.,2007).
   
  
 0.656
Rv0061c
Hypothetical protein; Rv0061c, len: 112 aa. Conserved hypothetical protein supported by RNA-seq data. Similar to MMAR_3839, 76% identity in 112 aa overlap. Replaces questionable ORF Rv0061 (MTV030.04).
      
 0.652
Rv1587c
Rv1587c, (MTCY336.17), len: 333 aa. Partial REP13E12 repeat protein (see citation below), nearly identical (but has been interrupted by phiRv1 prophage) to Q50655|MTCY251.13c|Rv0094c hypothetical 34.6 kDa protein from M. tuberculosis (317 aa), FASTA results: opt: 1511,E(): 1.1e-84, (97.75% identity in 224 aa overlap). Codon usage suggests that translation may involve frameshifting of Rv1588c mRNA in poly_C stretch into reading frame of Rv1587c. 3' end found in Rv1572c. Length extended since first submission (+115 aa). This region is a possible MT-complex-specific genomic island (See Be [...]
  
    0.616
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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