node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rv1691 | Rv1692 | Rv1691 | Rv1692 | Rv1691, MTCI125.13, len: 250 aa. Conserved hypothetical protein, similar to Q9S210|SCI51.30C|AL109848 Hypothetical protein from Streptomyces coelicolor (210 aa),FASTA score: opt: 556, E(): 6.4e-27, (50.6% identity in 180 aa overlap). | Probable phosphatase; Glycerol-phosphate phosphatase with a preference for D- glycerol 3-phosphate (sn-glycerol 1-phosphate) over L-glycerol 3- phosphate (sn-glycerol 3-phosphate). Is the final enzyme involved in the recycling/catabolism of glycerophospholipid polar heads. To a lesser extent, is also able to act on glycerol 2-phosphate and D- ribulose 5-phosphate, but cannot use D-glyceraldehyde 3-phosphate, dihydroxyacetone-phosphate, UMP or GMP as substrates. Belongs to the HAD-like hydrolase superfamily. | 0.996 |
Rv1691 | Rv1693 | Rv1691 | Rv1693 | Rv1691, MTCI125.13, len: 250 aa. Conserved hypothetical protein, similar to Q9S210|SCI51.30C|AL109848 Hypothetical protein from Streptomyces coelicolor (210 aa),FASTA score: opt: 556, E(): 6.4e-27, (50.6% identity in 180 aa overlap). | Rv1693, (MTCI125.15), len: 58 aa. Conserved hypothetical protein, shows some similarity to AL583921 hypothetical protein from Mycobacterium leprae (61 aa). Probable coiled-coil from aa 30 to 58. A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004). | 0.984 |
Rv1691 | alaS | Rv1691 | Rv2555c | Rv1691, MTCI125.13, len: 250 aa. Conserved hypothetical protein, similar to Q9S210|SCI51.30C|AL109848 Hypothetical protein from Streptomyces coelicolor (210 aa),FASTA score: opt: 556, E(): 6.4e-27, (50.6% identity in 180 aa overlap). | Probable alanyl-tRNA synthetase AlaS (alanine--tRNA ligase) (alanine translase) (ALARS); Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain; Belongs to the class-II aminoacyl-tRNA synthetase family. | 0.925 |
Rv1691 | htpG | Rv1691 | Rv2299c | Rv1691, MTCI125.13, len: 250 aa. Conserved hypothetical protein, similar to Q9S210|SCI51.30C|AL109848 Hypothetical protein from Streptomyces coelicolor (210 aa),FASTA score: opt: 556, E(): 6.4e-27, (50.6% identity in 180 aa overlap). | Chaperone protein HtpG; Molecular chaperone. Has ATPase activity. | 0.933 |
Rv1691 | mftF | Rv1691 | Rv0696 | Rv1691, MTCI125.13, len: 250 aa. Conserved hypothetical protein, similar to Q9S210|SCI51.30C|AL109848 Hypothetical protein from Streptomyces coelicolor (210 aa),FASTA score: opt: 556, E(): 6.4e-27, (50.6% identity in 180 aa overlap). | Probable membrane sugar transferase; May play a role in the maturation of mycofactocin, a conserved polypeptide that might serve as an electron carrier. The genes for mycofactocin and other proteins proposed to function in its maturation are found in a conserved gene cluster; Belongs to the glycosyltransferase 2 family. | 0.823 |
Rv1691 | ppnK | Rv1691 | Rv1695 | Rv1691, MTCI125.13, len: 250 aa. Conserved hypothetical protein, similar to Q9S210|SCI51.30C|AL109848 Hypothetical protein from Streptomyces coelicolor (210 aa),FASTA score: opt: 556, E(): 6.4e-27, (50.6% identity in 180 aa overlap). | Inorganic polyphosphate/ATP-NAD kinase PpnK (poly(P)/ATP NAD kinase); Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. It can use ATP and other nucleoside triphosphates as well as inorganic polyphosphate (poly(P)) as a source of phosphorus. | 0.986 |
Rv1691 | recN | Rv1691 | Rv1696 | Rv1691, MTCI125.13, len: 250 aa. Conserved hypothetical protein, similar to Q9S210|SCI51.30C|AL109848 Hypothetical protein from Streptomyces coelicolor (210 aa),FASTA score: opt: 556, E(): 6.4e-27, (50.6% identity in 180 aa overlap). | Probable DNA repair protein RecN (recombination protein N); May be involved in recombinational repair of damaged DNA. | 0.981 |
Rv1691 | rpoA | Rv1691 | Rv3457c | Rv1691, MTCI125.13, len: 250 aa. Conserved hypothetical protein, similar to Q9S210|SCI51.30C|AL109848 Hypothetical protein from Streptomyces coelicolor (210 aa),FASTA score: opt: 556, E(): 6.4e-27, (50.6% identity in 180 aa overlap). | DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.878 |
Rv1691 | rpoZ | Rv1691 | Rv1390 | Rv1691, MTCI125.13, len: 250 aa. Conserved hypothetical protein, similar to Q9S210|SCI51.30C|AL109848 Hypothetical protein from Streptomyces coelicolor (210 aa),FASTA score: opt: 556, E(): 6.4e-27, (50.6% identity in 180 aa overlap). | DNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. | 0.867 |
Rv1691 | tlyA | Rv1691 | Rv1694 | Rv1691, MTCI125.13, len: 250 aa. Conserved hypothetical protein, similar to Q9S210|SCI51.30C|AL109848 Hypothetical protein from Streptomyces coelicolor (210 aa),FASTA score: opt: 556, E(): 6.4e-27, (50.6% identity in 180 aa overlap). | 2'-O-methyltransferase TlyA; Acts as a host evasion factor, that significantly contributes to the pathogenesis of M.tuberculosis by modulating adaptive immune responses by inhibiting host-protective Th1 and Th17 cytokine responses as well as autophagy. Catalyzes the 2'-O-methylation at nucleotides C1409 in 16S rRNA and C1920 in 23S rRNA. Is likely involved in ribosomal biogenesis. Also exhibits hemolytic activity in vitro, by binding with and oligomerizing into host cell membranes. Belongs to the TlyA family. | 0.946 |
Rv1692 | Rv1691 | Rv1692 | Rv1691 | Probable phosphatase; Glycerol-phosphate phosphatase with a preference for D- glycerol 3-phosphate (sn-glycerol 1-phosphate) over L-glycerol 3- phosphate (sn-glycerol 3-phosphate). Is the final enzyme involved in the recycling/catabolism of glycerophospholipid polar heads. To a lesser extent, is also able to act on glycerol 2-phosphate and D- ribulose 5-phosphate, but cannot use D-glyceraldehyde 3-phosphate, dihydroxyacetone-phosphate, UMP or GMP as substrates. Belongs to the HAD-like hydrolase superfamily. | Rv1691, MTCI125.13, len: 250 aa. Conserved hypothetical protein, similar to Q9S210|SCI51.30C|AL109848 Hypothetical protein from Streptomyces coelicolor (210 aa),FASTA score: opt: 556, E(): 6.4e-27, (50.6% identity in 180 aa overlap). | 0.996 |
Rv1692 | Rv1693 | Rv1692 | Rv1693 | Probable phosphatase; Glycerol-phosphate phosphatase with a preference for D- glycerol 3-phosphate (sn-glycerol 1-phosphate) over L-glycerol 3- phosphate (sn-glycerol 3-phosphate). Is the final enzyme involved in the recycling/catabolism of glycerophospholipid polar heads. To a lesser extent, is also able to act on glycerol 2-phosphate and D- ribulose 5-phosphate, but cannot use D-glyceraldehyde 3-phosphate, dihydroxyacetone-phosphate, UMP or GMP as substrates. Belongs to the HAD-like hydrolase superfamily. | Rv1693, (MTCI125.15), len: 58 aa. Conserved hypothetical protein, shows some similarity to AL583921 hypothetical protein from Mycobacterium leprae (61 aa). Probable coiled-coil from aa 30 to 58. A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004). | 0.984 |
Rv1692 | ppnK | Rv1692 | Rv1695 | Probable phosphatase; Glycerol-phosphate phosphatase with a preference for D- glycerol 3-phosphate (sn-glycerol 1-phosphate) over L-glycerol 3- phosphate (sn-glycerol 3-phosphate). Is the final enzyme involved in the recycling/catabolism of glycerophospholipid polar heads. To a lesser extent, is also able to act on glycerol 2-phosphate and D- ribulose 5-phosphate, but cannot use D-glyceraldehyde 3-phosphate, dihydroxyacetone-phosphate, UMP or GMP as substrates. Belongs to the HAD-like hydrolase superfamily. | Inorganic polyphosphate/ATP-NAD kinase PpnK (poly(P)/ATP NAD kinase); Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. It can use ATP and other nucleoside triphosphates as well as inorganic polyphosphate (poly(P)) as a source of phosphorus. | 0.984 |
Rv1692 | recN | Rv1692 | Rv1696 | Probable phosphatase; Glycerol-phosphate phosphatase with a preference for D- glycerol 3-phosphate (sn-glycerol 1-phosphate) over L-glycerol 3- phosphate (sn-glycerol 3-phosphate). Is the final enzyme involved in the recycling/catabolism of glycerophospholipid polar heads. To a lesser extent, is also able to act on glycerol 2-phosphate and D- ribulose 5-phosphate, but cannot use D-glyceraldehyde 3-phosphate, dihydroxyacetone-phosphate, UMP or GMP as substrates. Belongs to the HAD-like hydrolase superfamily. | Probable DNA repair protein RecN (recombination protein N); May be involved in recombinational repair of damaged DNA. | 0.980 |
Rv1692 | tlyA | Rv1692 | Rv1694 | Probable phosphatase; Glycerol-phosphate phosphatase with a preference for D- glycerol 3-phosphate (sn-glycerol 1-phosphate) over L-glycerol 3- phosphate (sn-glycerol 3-phosphate). Is the final enzyme involved in the recycling/catabolism of glycerophospholipid polar heads. To a lesser extent, is also able to act on glycerol 2-phosphate and D- ribulose 5-phosphate, but cannot use D-glyceraldehyde 3-phosphate, dihydroxyacetone-phosphate, UMP or GMP as substrates. Belongs to the HAD-like hydrolase superfamily. | 2'-O-methyltransferase TlyA; Acts as a host evasion factor, that significantly contributes to the pathogenesis of M.tuberculosis by modulating adaptive immune responses by inhibiting host-protective Th1 and Th17 cytokine responses as well as autophagy. Catalyzes the 2'-O-methylation at nucleotides C1409 in 16S rRNA and C1920 in 23S rRNA. Is likely involved in ribosomal biogenesis. Also exhibits hemolytic activity in vitro, by binding with and oligomerizing into host cell membranes. Belongs to the TlyA family. | 0.944 |
Rv1693 | Rv1691 | Rv1693 | Rv1691 | Rv1693, (MTCI125.15), len: 58 aa. Conserved hypothetical protein, shows some similarity to AL583921 hypothetical protein from Mycobacterium leprae (61 aa). Probable coiled-coil from aa 30 to 58. A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004). | Rv1691, MTCI125.13, len: 250 aa. Conserved hypothetical protein, similar to Q9S210|SCI51.30C|AL109848 Hypothetical protein from Streptomyces coelicolor (210 aa),FASTA score: opt: 556, E(): 6.4e-27, (50.6% identity in 180 aa overlap). | 0.984 |
Rv1693 | Rv1692 | Rv1693 | Rv1692 | Rv1693, (MTCI125.15), len: 58 aa. Conserved hypothetical protein, shows some similarity to AL583921 hypothetical protein from Mycobacterium leprae (61 aa). Probable coiled-coil from aa 30 to 58. A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004). | Probable phosphatase; Glycerol-phosphate phosphatase with a preference for D- glycerol 3-phosphate (sn-glycerol 1-phosphate) over L-glycerol 3- phosphate (sn-glycerol 3-phosphate). Is the final enzyme involved in the recycling/catabolism of glycerophospholipid polar heads. To a lesser extent, is also able to act on glycerol 2-phosphate and D- ribulose 5-phosphate, but cannot use D-glyceraldehyde 3-phosphate, dihydroxyacetone-phosphate, UMP or GMP as substrates. Belongs to the HAD-like hydrolase superfamily. | 0.984 |
Rv1693 | ppnK | Rv1693 | Rv1695 | Rv1693, (MTCI125.15), len: 58 aa. Conserved hypothetical protein, shows some similarity to AL583921 hypothetical protein from Mycobacterium leprae (61 aa). Probable coiled-coil from aa 30 to 58. A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004). | Inorganic polyphosphate/ATP-NAD kinase PpnK (poly(P)/ATP NAD kinase); Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. It can use ATP and other nucleoside triphosphates as well as inorganic polyphosphate (poly(P)) as a source of phosphorus. | 0.984 |
Rv1693 | recN | Rv1693 | Rv1696 | Rv1693, (MTCI125.15), len: 58 aa. Conserved hypothetical protein, shows some similarity to AL583921 hypothetical protein from Mycobacterium leprae (61 aa). Probable coiled-coil from aa 30 to 58. A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004). | Probable DNA repair protein RecN (recombination protein N); May be involved in recombinational repair of damaged DNA. | 0.981 |
Rv1693 | tlyA | Rv1693 | Rv1694 | Rv1693, (MTCI125.15), len: 58 aa. Conserved hypothetical protein, shows some similarity to AL583921 hypothetical protein from Mycobacterium leprae (61 aa). Probable coiled-coil from aa 30 to 58. A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004). | 2'-O-methyltransferase TlyA; Acts as a host evasion factor, that significantly contributes to the pathogenesis of M.tuberculosis by modulating adaptive immune responses by inhibiting host-protective Th1 and Th17 cytokine responses as well as autophagy. Catalyzes the 2'-O-methylation at nucleotides C1409 in 16S rRNA and C1920 in 23S rRNA. Is likely involved in ribosomal biogenesis. Also exhibits hemolytic activity in vitro, by binding with and oligomerizing into host cell membranes. Belongs to the TlyA family. | 0.945 |