STRINGSTRING
engA engA cmk cmk Rv1711 Rv1711 scpB scpB hflX hflX scpA scpA prfA prfA Rv1708 Rv1708 dnaG dnaG gpdA2 gpdA2 gpdA1 gpdA1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
engAProbable GTP-binding protein EngA; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. (463 aa)    
Predicted Functional Partners:
cmk
Cytidylate kinase Cmk (CMP kinase) (cytidine monophosphate kinase) (ck); Rv1712, (MTCI125.34), len: 230 aa. cmk, cytidylate kinase, highly similar to many e.g. KCY_ECOLI|P23863 cytidylate kinase from Escherichia coli (227 aa), FASTA scores: opt: 534, E (): 0, (40.3% identity in 221 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). Equivalent to Z95117|MLCB1351_2 from Mycobacterium leprae (223 aa) (73.5% identity in 226 aa overlap). Belongs to the cytidylate kinase family,subfamily 1.
  
 0.999
Rv1711
Rv1711, (MTCI125.33), len: 254 aa. Conserved hypothetical protein, highly similar to a large family of hypothetical proteins e.g. P37765|YCIL_ECOLI from Escherichia coli (291 aa), FASTA scores: opt: 496, E(): 1.1e-29, (41.6% identity in 250 aa overlap); 9S232|SCI51.08C|AL109848 putative pseudouridine synthase from Streptomyces coelicolor (371 aa), FASTA scores: opt: 818, E(): 0, (53.1% identity in 245 aa overlap). Equivalent to O05668|MLCB1351.03C|Z95117 Hypothetical protein from Mycobacterium leprae (256 aa), (80.5% identity in 256 aa overlap). Contains PS01149 Hypothetical yciL/yejD/ [...]
 
  
 0.995
scpB
Possible segregation and condensation protein ScpB; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves.
 
  
 0.981
hflX
Probable GTP-binding protein HflX; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
 
  
 0.944
scpA
Possible segregation and condensation protein ScpA; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.
 
  
 0.937
prfA
Probable peptide chain release factor 1 PrfA (RF-1); Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
  
  
 0.916
Rv1708
Putative initiation inhibitor protein; May play a role in septum formation.
  
    0.883
dnaG
Probable DNA primase DnaG; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Belongs to the DnaG primase family.
  
  
 0.873
gpdA2
Glycerol-3-phosphate dehydrogenase [NAD(P)+]; Rv2982c, (MTCY349.05), len: 334 aa. Probable gpdA2 (alternate gene name: gpsA), glycerol-3-phosphate dehydrogenase [NAD(P)+], equivalent to Q9CBR9|GPDA_MYCLE glycerol-3-phosphate dehydrogenase [NAD(P)+] from Mycobacterium leprae (349 aa), FASTA scores: opt: 1686,E(): 1.7e-95, (77.95% identity in 349 aa overlap). Also highly similar to others e.g. Q9ZBS0|GPDA_STRCO from Streptomyces coelicolor (336 aa), FASTA scores: opt: 1165,E(): 9.8e-64, (56.25% identity in 327 aa overlap); P46919|GPDA_BACSU from Bacillus subtilis (345 aa), FASTA scores: [...]
 
  
 0.853
gpdA1
Probable glycerol-3-phosphate dehydrogenase 2 [NAD(P)+]; Rv0564c, (MTV039.02c), len: 341 aa. Possible gpdA1(alternate gene names: gpsA, glyC),glycerol-3-phosphate dehydrogenase [NAD(P)+] dependent,similar to many other glycerol-3-phosphate dehydrogenases e.g. P46919|GPDA_BACSU from Bacillus subtilis (345 aa),FASTA scores: opt: 731, E(): 0, (37.3% identity in 332 aa overlap); etc. Also similar to Rv2982c|gpdA2|MTCY349.05|Z83018|MTCY349_5 from Mycobacterium tuberculosis (334 aa), FASTA scores: opt: 740, E(): 0, (40.4% identity in 322 aa overlap). Contains PS00017 ATP/GTP-binding site mot [...]
 
  
 0.812
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.