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Rv1717 Rv1717 Rv1716 Rv1716 fadB3 fadB3 Rv1714 Rv1714 Rv1718 Rv1718 Rv1096 Rv1096 Rv1419 Rv1419 Rv1719 Rv1719 rmlC rmlC bglS bglS gltB gltB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
Rv1717Rv1717, (MTCY04C12.02), len: 116 aa. Conserved hypothetical protein, similar to O29060|AF1208|AE001021 Hypothetical protein from Arecheoglobus fulgidus (114 aa),FASTA scores: opt: 254, E(): 3.3e-09, (37.7% identity in 114 aa overlap). (116 aa)    
Predicted Functional Partners:
Rv1716
Conserved hypothetical protein; Rv1716, (MTV048.03,MTCY04C12.01), len: 276 aa. Conserved hypothetical protein, shows high similarity with AF1200|O29068|AE001021_11A conserved protein of Archaeoglobus fulgidus, gp fulgidus section 7 (278 aa),FASTA scores: E(): 0, (61.8% identity in 251 a a overlap); also weak similarity to several polyketide cyclases e.g. O68500|AF048833|DPSY from Streptomyces peucetius (272 aa),FASTA scores: opt: 194, E(): 1.7e-05, (29.6% identity in 223 aa overlap).
 
    0.992
fadB3
Rv1715, (MTV048.02), len: 304 aa. Probable fadB3,3-hydroxybutyryl-CoA dehydrogenase, highly similar to many e.g. NP_107236.1|NC_002678 3-hydroxybutyryl-CoA dehydrogenase from Mesorhizobium loti (309 aa); NP_250319.1|NC_002516 probable 3-hydroxyacyl-CoA dehydrogenase from Pseudomonas aeruginosa (509 aa); P45856|HBD_BACSU probable 3-hydroxybutyryl-CoA dehydrogenase from Bacillus subtilis (287 aa), FASTA scores: opt: 488, E(): 1.5e-24, (38.7% identity in 279 aa overlap); etc. Could belong to the 3-hydroxyacyl-CoA dehydrogenase family.
 
    0.982
Rv1714
Rv1714, (MTV048.01), len: 270 aa. Probable oxidoreductase similar to many e.g. AE0010|AE001021_4 Archaeoglobus fulgidus section 79 (281 aa), FASTA scores: opt: 578, E(): 3.3e-31, (38.9% identity in 265 aa overlap). Also similar to several other M. tuberculosis oxidoreductases e.g. Rv1544, etc.
 
    0.976
Rv1718
Rv1718, (MTCY04C12.03), len: 272 aa. Conserved hypothetical protein, similar to O29058|AF1210|AE001021 Hypothetical protein from Archeoglobus (313 aa), FASTA scores: opt: 301, E(): 8e-23, (31.6% identity in 301 aa overlap).
 
    0.969
Rv1096
Rv1096, (MTV017.49), len: 291 aa. Possible glycosyl hydrolase, possibly deacetylase or esterase. Equivalent to AL049491|MLCB1222_13 Mycobacterium leprae (291 aa) (81.3% identity in 289 aa overlap). Similar at the C-terminus to enzymes involved in carbohydrate degradation including Z99110|BSUB0007_92 endo-1,4-beta-xylanase homolog yjeA from Bacillus subtilis (467 aa), FASTA scores: opt: 418, E(): 2.6e-17, (38.6% identity in 184 aa overlap); M64552|STMXLNB_2 acetyl-xylan esterase from Streptomyces lividans (335 aa), FASTA scores: opt: 371, E(): 1.1e-14,(31.6% identity in 237 aa overlap); [...]
      
 0.870
Rv1419
Unknown protein; Rv1419, (MTCY21B4.37), len: 157 aa. Unknown protein. Predicted to be an outer membrane protein (See Song et al.,2008).
   
  
 0.801
Rv1719
Rv1719, (MTCY04C12.04), len: 259 aa. Probable transcriptional regulatory protein, similar to YIAJ_ECOLI|P37671 hypothetical transcriptional regulator from Escherichia coli (282 aa), FASTA scores: opt: 353,E(): 3.2e-15, (31.1% identity in 235 aa overlap). Similar to Mycobacterium tuberculosis hypothetical IclR-family transcriptional regulators Rv2989, Rv1773c. Helix-turn-helix motif from aa 34-55 (+6.94 SD).
 
    0.784
rmlC
dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Involved in the biosynthesis of the dTDP-L-rhamnose which is a component of the critical linker, D-N-acetylglucosamine-L-rhamnose disaccharide, which connects the galactan region of arabinogalactan to peptidoglycan via a phosphodiester linkage.
   
  
 0.736
bglS
Probable beta-glucosidase BglS (gentiobiase) (cellobiase) (beta-D-glucoside glucohydrolase); Rv0186, (MTCI28.25b), len: 691 aa. Probable bglS,beta-glucosidase, highly similar to many e.g. BGLS_AGRTU|P27034 beta-glucosidase from Agrobacterium tumefaciens (818 aa), FASTA scores: opt: 643, E(): 0,(32.5% identity in 842 aa overlap). Seems to belong to family 3 of glycosyl hydrolases.
   
  
 0.661
gltB
Glutamate synthase [NADPH] large chain; Rv3859c, (MTCY01A6.09), len: 1527 aa. Probable gltB,ferredoxin-dependent glutamate synthase large subunit,equivalent to Q9CDD5|GLTB|ML0061 putative ferredoxin-dependent glutamate synthase from Mycobacterium leprae (1527 aa), FASTA scores: opt: 9277, E(): 0, (90.25% identity in 1527 aa overlap). Also highly similar to many e.g. Q9S2Y9|SC3A3.04c from Streptomyces coelicolor (1514 aa), FASTA scores: opt: 5939, E(): 0, (64.3% identity in 1544 aa overlap); Q9Z465|GLTB from Corynebacterium glutamicum (Brevibacterium flavum) (1510 aa), FASTA scores: opt [...]
       0.544
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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