STRINGSTRING
vapC34 vapC34 vapB34 vapB34 vapB30 vapB30 Rv1742 Rv1742 Rv1739c Rv1739c pknE pknE vapB36 vapB36 vapB28 vapB28 vapB42 vapB42
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
vapC34Possible toxin VapC34. Contains PIN domain; Toxic component of a possible type II toxin-antitoxin (TA) system. A putative RNase. Its cognate antitoxin is VapB34 (By similarity).; Belongs to the PINc/VapC protein family. (82 aa)    
Predicted Functional Partners:
vapB34
Possible antitoxin VapB34; Antitoxin component of a possible type II toxin-antitoxin (TA) system. The cognate toxin is VapC34.
  
 
 0.972
vapB30
Possible antitoxin VapB30; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC30.
  
 
 0.876
Rv1742
Unknown protein; Rv1742, (MTCY28.04,MTCY04C12.27), len: 245 aa. Unknown protein.
  
    0.792
Rv1739c
Probable sulphate-transport transmembrane protein ABC transporter; Expression in E.coli induces sulfate uptake during early- to mid-log phase growth. Uptake is maximal at pH 6.0, is sulfate-specific, requires E.coli CysA and the transmembrane segment but not the STAS domain of the protein.
  
    0.572
pknE
Probable transmembrane serine/threonine-protein kinase E PknE (protein kinase E) (STPK E); Important for survival of the bacterium in the host during infection. Promotes the survival of infected macrophages by activating multiple signaling responses and suppressing apoptosis of macrophages during nitrate stress. May contribute to the adaptation of M.tuberculosis during stress conditions by maintaining the cellular integrity. Can phosphorylate the FHA domain of Rv1747. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
  
    0.536
vapB36
Possible antitoxin VapB36; Possibly the antitoxin component of a type II toxin-antitoxin (TA) system. Its cognate toxin is VapC36.
   
 
 0.464
vapB28
Possible antitoxin VapB28; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC28.
  
 
 0.455
vapB42
Possible antitoxin VapB42; Possibly the antitoxin component of a type II toxin-antitoxin (TA) system. Its cognate toxin is VapC42.
  
 
 0.452
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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