node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PE_PGRS35 | nrdF1 | Rv1983 | Rv1981c | PE-PGRS family protein PE_PGRS35; Rv1983, (MTCY39.36c), len: 558 aa. PE_PGRS35, Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see Brennan & Delogu 2002). Similar to other PE proteins e.g. Rv0977, etc. Contains PS00141 Eukaryotic and viral aspartyl proteases active site. | Ribonucleoside-diphosphate reductase subunit beta nrdF1; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity). Two genes for this protein are present in M.tuberculosis; this is thought to not be the active form. When coexpressed in E.coli with nrdE the 2 proteins do not complement a temperature-sensitive E.coli mutant, whereas the other gene (nrdF2) does complement; Belongs to the ribonucleoside diphosphate reductase small chain family. | 0.493 |
PE_PGRS35 | vapB36 | Rv1983 | Rv1982A | PE-PGRS family protein PE_PGRS35; Rv1983, (MTCY39.36c), len: 558 aa. PE_PGRS35, Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see Brennan & Delogu 2002). Similar to other PE proteins e.g. Rv0977, etc. Contains PS00141 Eukaryotic and viral aspartyl proteases active site. | Possible antitoxin VapB36; Possibly the antitoxin component of a type II toxin-antitoxin (TA) system. Its cognate toxin is VapC36. | 0.535 |
PE_PGRS35 | vapC36 | Rv1983 | Rv1982c | PE-PGRS family protein PE_PGRS35; Rv1983, (MTCY39.36c), len: 558 aa. PE_PGRS35, Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see Brennan & Delogu 2002). Similar to other PE proteins e.g. Rv0977, etc. Contains PS00141 Eukaryotic and viral aspartyl proteases active site. | Possible toxin VapC36. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase. Its cognate antitoxin is VapB36 (By similarity). Belongs to the PINc/VapC protein family. | 0.637 |
Rv0919 | vapC36 | Rv0919 | Rv1982c | GCN5-related N-acetyltransferase; Rv0919, (MTCY21C12.13), len: 166 aa. Probable acetyltransferase. Contains GNAT (Gcn5-related N-acetyltransferase) domain. See Vetting et al. 2005. Some similarity to Q50115 hypothetical protein from Mycobacterium leprae (90 aa), FASTA scores: opt: 243, E(): 5.3e-11, (56.5% identity in 85 aa overlap). Alternative nucleotide at position 1025106 (T->C; F141F) has been observed. | Possible toxin VapC36. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase. Its cognate antitoxin is VapB36 (By similarity). Belongs to the PINc/VapC protein family. | 0.492 |
mce3D | vapB36 | Rv1969 | Rv1982A | Mce-family protein Mce3D; Rv1969, (MTV051.07), len: 423 aa. Mce3D; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below), highly similar to Mycobacterium tuberculosis proteins O07416|Rv0172|MTCI28.12|mce1D (530 aa); O07786|Rv0592|MTCY19H5.30c|mce2D (508 aa); etc. Also highly similar to others e.g. NP_302659.1|NC_002677 putative secreted protein from Mycobacterium leprae (531 aa); CAC12795.1|AL445327 putative secreted protein from Streptomyces coelicolor (337 aa); etc. Contains a possible N-terminal signal sequence or membrane anchor. The transcripti [...] | Possible antitoxin VapB36; Possibly the antitoxin component of a type II toxin-antitoxin (TA) system. Its cognate toxin is VapC36. | 0.880 |
mce3D | vapC36 | Rv1969 | Rv1982c | Mce-family protein Mce3D; Rv1969, (MTV051.07), len: 423 aa. Mce3D; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below), highly similar to Mycobacterium tuberculosis proteins O07416|Rv0172|MTCI28.12|mce1D (530 aa); O07786|Rv0592|MTCY19H5.30c|mce2D (508 aa); etc. Also highly similar to others e.g. NP_302659.1|NC_002677 putative secreted protein from Mycobacterium leprae (531 aa); CAC12795.1|AL445327 putative secreted protein from Streptomyces coelicolor (337 aa); etc. Contains a possible N-terminal signal sequence or membrane anchor. The transcripti [...] | Possible toxin VapC36. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase. Its cognate antitoxin is VapB36 (By similarity). Belongs to the PINc/VapC protein family. | 0.582 |
nrdF1 | PE_PGRS35 | Rv1981c | Rv1983 | Ribonucleoside-diphosphate reductase subunit beta nrdF1; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity). Two genes for this protein are present in M.tuberculosis; this is thought to not be the active form. When coexpressed in E.coli with nrdE the 2 proteins do not complement a temperature-sensitive E.coli mutant, whereas the other gene (nrdF2) does complement; Belongs to the ribonucleoside diphosphate reductase small chain family. | PE-PGRS family protein PE_PGRS35; Rv1983, (MTCY39.36c), len: 558 aa. PE_PGRS35, Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see Brennan & Delogu 2002). Similar to other PE proteins e.g. Rv0977, etc. Contains PS00141 Eukaryotic and viral aspartyl proteases active site. | 0.493 |
nrdF1 | vapB36 | Rv1981c | Rv1982A | Ribonucleoside-diphosphate reductase subunit beta nrdF1; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity). Two genes for this protein are present in M.tuberculosis; this is thought to not be the active form. When coexpressed in E.coli with nrdE the 2 proteins do not complement a temperature-sensitive E.coli mutant, whereas the other gene (nrdF2) does complement; Belongs to the ribonucleoside diphosphate reductase small chain family. | Possible antitoxin VapB36; Possibly the antitoxin component of a type II toxin-antitoxin (TA) system. Its cognate toxin is VapC36. | 0.443 |
nrdF1 | vapC36 | Rv1981c | Rv1982c | Ribonucleoside-diphosphate reductase subunit beta nrdF1; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity). Two genes for this protein are present in M.tuberculosis; this is thought to not be the active form. When coexpressed in E.coli with nrdE the 2 proteins do not complement a temperature-sensitive E.coli mutant, whereas the other gene (nrdF2) does complement; Belongs to the ribonucleoside diphosphate reductase small chain family. | Possible toxin VapC36. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase. Its cognate antitoxin is VapB36 (By similarity). Belongs to the PINc/VapC protein family. | 0.446 |
vapB11 | vapB30 | Rv1560 | Rv0623 | Possible antitoxin VapB11; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and M.smegmatis neutralizes the effect of cognate toxin VapC11. | Possible antitoxin VapB30; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC30. | 0.445 |
vapB11 | vapC36 | Rv1560 | Rv1982c | Possible antitoxin VapB11; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and M.smegmatis neutralizes the effect of cognate toxin VapC11. | Possible toxin VapC36. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase. Its cognate antitoxin is VapB36 (By similarity). Belongs to the PINc/VapC protein family. | 0.506 |
vapB28 | vapB30 | Rv0608 | Rv0623 | Possible antitoxin VapB28; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC28. | Possible antitoxin VapB30; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC30. | 0.687 |
vapB28 | vapB34 | Rv0608 | Rv1740 | Possible antitoxin VapB28; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC28. | Possible antitoxin VapB34; Antitoxin component of a possible type II toxin-antitoxin (TA) system. The cognate toxin is VapC34. | 0.619 |
vapB28 | vapC36 | Rv0608 | Rv1982c | Possible antitoxin VapB28; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC28. | Possible toxin VapC36. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase. Its cognate antitoxin is VapB36 (By similarity). Belongs to the PINc/VapC protein family. | 0.452 |
vapB30 | vapB11 | Rv0623 | Rv1560 | Possible antitoxin VapB30; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC30. | Possible antitoxin VapB11; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and M.smegmatis neutralizes the effect of cognate toxin VapC11. | 0.445 |
vapB30 | vapB28 | Rv0623 | Rv0608 | Possible antitoxin VapB30; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC30. | Possible antitoxin VapB28; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC28. | 0.687 |
vapB30 | vapC36 | Rv0623 | Rv1982c | Possible antitoxin VapB30; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC30. | Possible toxin VapC36. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase. Its cognate antitoxin is VapB36 (By similarity). Belongs to the PINc/VapC protein family. | 0.948 |
vapB34 | vapB28 | Rv1740 | Rv0608 | Possible antitoxin VapB34; Antitoxin component of a possible type II toxin-antitoxin (TA) system. The cognate toxin is VapC34. | Possible antitoxin VapB28; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC28. | 0.619 |
vapB34 | vapC36 | Rv1740 | Rv1982c | Possible antitoxin VapB34; Antitoxin component of a possible type II toxin-antitoxin (TA) system. The cognate toxin is VapC34. | Possible toxin VapC36. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase. Its cognate antitoxin is VapB36 (By similarity). Belongs to the PINc/VapC protein family. | 0.784 |
vapB36 | PE_PGRS35 | Rv1982A | Rv1983 | Possible antitoxin VapB36; Possibly the antitoxin component of a type II toxin-antitoxin (TA) system. Its cognate toxin is VapC36. | PE-PGRS family protein PE_PGRS35; Rv1983, (MTCY39.36c), len: 558 aa. PE_PGRS35, Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see Brennan & Delogu 2002). Similar to other PE proteins e.g. Rv0977, etc. Contains PS00141 Eukaryotic and viral aspartyl proteases active site. | 0.535 |