Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Rv0023 | Rv0238 | Rv0023 | Rv0238 | Rv0023, (MTCY10H4.23), len: 256 aa. Possible transcriptional regulator. Contains probable helix-turn helix motif from aa 19 to 40 (Score 1615, +4.69 SD). | Rv0238, (MTV034.04), len: 204 aa. Possible transcriptional regulatory protein, TetR family, equivalent to AL022486|MLCB1883_9|T44874 probable transcription regulator from Mycobacterium leprae (208 aa), FASTA scores: opt: 1029, E(): 0, (80.9% identity in 199 aa overlap). Also similar to others e.g. CAB77290.1|AL160312 putative TetR-family regulatory protein from Streptomyces coelicolor (240 aa). Also similar to Mycobacterium tuberculosis proteins Z95120|Rv3208 (228 aa), FASTA scores: opt: 266,E(): 8.3e-12, (28.1% identity in 196 aa overlap); and Rv1019 (197 aa). | 0.861 |
| Rv0023 | Rv2034 | Rv0023 | Rv2034 | Rv0023, (MTCY10H4.23), len: 256 aa. Possible transcriptional regulator. Contains probable helix-turn helix motif from aa 19 to 40 (Score 1615, +4.69 SD). | ArsR repressor protein; Involved in the regulation of lipid metabolism and hypoxic response. Positively regulates transcription of various genes, such as phoP, groEL2 and dosR. Negatively regulates its own transcription. Acts by binding to a specific palindromic sequence motif in promoter regions. | 0.502 |
| Rv0023 | mbcA | Rv0023 | Rv1990c | Rv0023, (MTCY10H4.23), len: 256 aa. Possible transcriptional regulator. Contains probable helix-turn helix motif from aa 19 to 40 (Score 1615, +4.69 SD). | Probable transcriptional regulatory protein; Antitoxin component of a type II toxin-antitoxin (TA) system. Neutralizes the activity of cognate toxin MbcT by blocking access to the toxin active site. | 0.861 |
| Rv0023 | whiA | Rv0023 | Rv1423 | Rv0023, (MTCY10H4.23), len: 256 aa. Possible transcriptional regulator. Contains probable helix-turn helix motif from aa 19 to 40 (Score 1615, +4.69 SD). | Probable transcriptional regulatory protein WhiA; Involved in cell division and chromosome segregation. | 0.679 |
| Rv0238 | Rv0023 | Rv0238 | Rv0023 | Rv0238, (MTV034.04), len: 204 aa. Possible transcriptional regulatory protein, TetR family, equivalent to AL022486|MLCB1883_9|T44874 probable transcription regulator from Mycobacterium leprae (208 aa), FASTA scores: opt: 1029, E(): 0, (80.9% identity in 199 aa overlap). Also similar to others e.g. CAB77290.1|AL160312 putative TetR-family regulatory protein from Streptomyces coelicolor (240 aa). Also similar to Mycobacterium tuberculosis proteins Z95120|Rv3208 (228 aa), FASTA scores: opt: 266,E(): 8.3e-12, (28.1% identity in 196 aa overlap); and Rv1019 (197 aa). | Rv0023, (MTCY10H4.23), len: 256 aa. Possible transcriptional regulator. Contains probable helix-turn helix motif from aa 19 to 40 (Score 1615, +4.69 SD). | 0.861 |
| Rv0238 | mbcA | Rv0238 | Rv1990c | Rv0238, (MTV034.04), len: 204 aa. Possible transcriptional regulatory protein, TetR family, equivalent to AL022486|MLCB1883_9|T44874 probable transcription regulator from Mycobacterium leprae (208 aa), FASTA scores: opt: 1029, E(): 0, (80.9% identity in 199 aa overlap). Also similar to others e.g. CAB77290.1|AL160312 putative TetR-family regulatory protein from Streptomyces coelicolor (240 aa). Also similar to Mycobacterium tuberculosis proteins Z95120|Rv3208 (228 aa), FASTA scores: opt: 266,E(): 8.3e-12, (28.1% identity in 196 aa overlap); and Rv1019 (197 aa). | Probable transcriptional regulatory protein; Antitoxin component of a type II toxin-antitoxin (TA) system. Neutralizes the activity of cognate toxin MbcT by blocking access to the toxin active site. | 0.653 |
| Rv0238 | whiA | Rv0238 | Rv1423 | Rv0238, (MTV034.04), len: 204 aa. Possible transcriptional regulatory protein, TetR family, equivalent to AL022486|MLCB1883_9|T44874 probable transcription regulator from Mycobacterium leprae (208 aa), FASTA scores: opt: 1029, E(): 0, (80.9% identity in 199 aa overlap). Also similar to others e.g. CAB77290.1|AL160312 putative TetR-family regulatory protein from Streptomyces coelicolor (240 aa). Also similar to Mycobacterium tuberculosis proteins Z95120|Rv3208 (228 aa), FASTA scores: opt: 266,E(): 8.3e-12, (28.1% identity in 196 aa overlap); and Rv1019 (197 aa). | Probable transcriptional regulatory protein WhiA; Involved in cell division and chromosome segregation. | 0.859 |
| Rv1990A | mbcA | Rv1990A | Rv1990c | Rv1990A, len: 111 aa. Possible dehydrogenase (fragment), similar to N-terminal part of several dehydrogenases and hypothetical proteins, e.g. Rv2750|MTV002.15|AL008967 from Mycobacterium tuberculosis (272 aa), FASTA scores: opt: 151, E(): 0.0045, (47.45% identity in 78 aa overlap), but lacks C-terminal part. Maybe a pseudogene. Also similar to U17129|RSU17129_7 putative short-chain alcohol dehydrogenase from Rhodococcus erythropolis (275 aa), FASTA scores: opt: 142, E(): 0.018,(54.15% identity in 48 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et [...] | Probable transcriptional regulatory protein; Antitoxin component of a type II toxin-antitoxin (TA) system. Neutralizes the activity of cognate toxin MbcT by blocking access to the toxin active site. | 0.430 |
| Rv1990A | mbcT | Rv1990A | Rv1989c | Rv1990A, len: 111 aa. Possible dehydrogenase (fragment), similar to N-terminal part of several dehydrogenases and hypothetical proteins, e.g. Rv2750|MTV002.15|AL008967 from Mycobacterium tuberculosis (272 aa), FASTA scores: opt: 151, E(): 0.0045, (47.45% identity in 78 aa overlap), but lacks C-terminal part. Maybe a pseudogene. Also similar to U17129|RSU17129_7 putative short-chain alcohol dehydrogenase from Rhodococcus erythropolis (275 aa), FASTA scores: opt: 142, E(): 0.018,(54.15% identity in 48 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et [...] | Hypothetical protein; Toxic component of a type II toxin-antitoxin (TA) system. Neutralized by cognate antitoxin MbcA. Degrades NAD(+) by phosphorolysis. Expression in the absence of its cognate antitoxin MbcA causes dramatic reduction of intracellular NAD(+) levels and is deleterious to cell growth, causing cell death. In a SCID mouse infection model, mice infected with bacteria overexpressing this protein survive longer. Overexpression of this protein in a mouse infection model at 21 days leads to bacterial death, and shows a synergistic 100-fold increase in mouse survival when combi [...] | 0.454 |
| Rv1990A | mftR | Rv1990A | Rv0691c | Rv1990A, len: 111 aa. Possible dehydrogenase (fragment), similar to N-terminal part of several dehydrogenases and hypothetical proteins, e.g. Rv2750|MTV002.15|AL008967 from Mycobacterium tuberculosis (272 aa), FASTA scores: opt: 151, E(): 0.0045, (47.45% identity in 78 aa overlap), but lacks C-terminal part. Maybe a pseudogene. Also similar to U17129|RSU17129_7 putative short-chain alcohol dehydrogenase from Rhodococcus erythropolis (275 aa), FASTA scores: opt: 142, E(): 0.018,(54.15% identity in 48 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et [...] | Probable transcriptional regulatory protein; May regulate a gene cluster involved in mycofactocin expression. Mycofactocin is a conserved polypeptide that might serve as an electron carrier. | 0.636 |
| Rv2034 | Rv0023 | Rv2034 | Rv0023 | ArsR repressor protein; Involved in the regulation of lipid metabolism and hypoxic response. Positively regulates transcription of various genes, such as phoP, groEL2 and dosR. Negatively regulates its own transcription. Acts by binding to a specific palindromic sequence motif in promoter regions. | Rv0023, (MTCY10H4.23), len: 256 aa. Possible transcriptional regulator. Contains probable helix-turn helix motif from aa 19 to 40 (Score 1615, +4.69 SD). | 0.502 |
| Rv2034 | mbcA | Rv2034 | Rv1990c | ArsR repressor protein; Involved in the regulation of lipid metabolism and hypoxic response. Positively regulates transcription of various genes, such as phoP, groEL2 and dosR. Negatively regulates its own transcription. Acts by binding to a specific palindromic sequence motif in promoter regions. | Probable transcriptional regulatory protein; Antitoxin component of a type II toxin-antitoxin (TA) system. Neutralizes the activity of cognate toxin MbcT by blocking access to the toxin active site. | 0.644 |
| Rv2034 | mbcT | Rv2034 | Rv1989c | ArsR repressor protein; Involved in the regulation of lipid metabolism and hypoxic response. Positively regulates transcription of various genes, such as phoP, groEL2 and dosR. Negatively regulates its own transcription. Acts by binding to a specific palindromic sequence motif in promoter regions. | Hypothetical protein; Toxic component of a type II toxin-antitoxin (TA) system. Neutralized by cognate antitoxin MbcA. Degrades NAD(+) by phosphorolysis. Expression in the absence of its cognate antitoxin MbcA causes dramatic reduction of intracellular NAD(+) levels and is deleterious to cell growth, causing cell death. In a SCID mouse infection model, mice infected with bacteria overexpressing this protein survive longer. Overexpression of this protein in a mouse infection model at 21 days leads to bacterial death, and shows a synergistic 100-fold increase in mouse survival when combi [...] | 0.457 |
| higA2 | mbcA | Rv2021c | Rv1990c | Transcriptional regulatory protein; Putative antitoxin component of a type II toxin-antitoxin (TA) system. Its cognate toxin would be HigB2. | Probable transcriptional regulatory protein; Antitoxin component of a type II toxin-antitoxin (TA) system. Neutralizes the activity of cognate toxin MbcT by blocking access to the toxin active site. | 0.533 |
| higA2 | vapB23 | Rv2021c | Rv2862A | Transcriptional regulatory protein; Putative antitoxin component of a type II toxin-antitoxin (TA) system. Its cognate toxin would be HigB2. | Possible antitoxin VapB23; Putative antitoxin component of a possible type II toxin- antitoxin (TA) system. The cognate toxin is VapC23. | 0.511 |
| mbcA | Rv0023 | Rv1990c | Rv0023 | Probable transcriptional regulatory protein; Antitoxin component of a type II toxin-antitoxin (TA) system. Neutralizes the activity of cognate toxin MbcT by blocking access to the toxin active site. | Rv0023, (MTCY10H4.23), len: 256 aa. Possible transcriptional regulator. Contains probable helix-turn helix motif from aa 19 to 40 (Score 1615, +4.69 SD). | 0.861 |
| mbcA | Rv0238 | Rv1990c | Rv0238 | Probable transcriptional regulatory protein; Antitoxin component of a type II toxin-antitoxin (TA) system. Neutralizes the activity of cognate toxin MbcT by blocking access to the toxin active site. | Rv0238, (MTV034.04), len: 204 aa. Possible transcriptional regulatory protein, TetR family, equivalent to AL022486|MLCB1883_9|T44874 probable transcription regulator from Mycobacterium leprae (208 aa), FASTA scores: opt: 1029, E(): 0, (80.9% identity in 199 aa overlap). Also similar to others e.g. CAB77290.1|AL160312 putative TetR-family regulatory protein from Streptomyces coelicolor (240 aa). Also similar to Mycobacterium tuberculosis proteins Z95120|Rv3208 (228 aa), FASTA scores: opt: 266,E(): 8.3e-12, (28.1% identity in 196 aa overlap); and Rv1019 (197 aa). | 0.653 |
| mbcA | Rv1990A | Rv1990c | Rv1990A | Probable transcriptional regulatory protein; Antitoxin component of a type II toxin-antitoxin (TA) system. Neutralizes the activity of cognate toxin MbcT by blocking access to the toxin active site. | Rv1990A, len: 111 aa. Possible dehydrogenase (fragment), similar to N-terminal part of several dehydrogenases and hypothetical proteins, e.g. Rv2750|MTV002.15|AL008967 from Mycobacterium tuberculosis (272 aa), FASTA scores: opt: 151, E(): 0.0045, (47.45% identity in 78 aa overlap), but lacks C-terminal part. Maybe a pseudogene. Also similar to U17129|RSU17129_7 putative short-chain alcohol dehydrogenase from Rhodococcus erythropolis (275 aa), FASTA scores: opt: 142, E(): 0.018,(54.15% identity in 48 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et [...] | 0.430 |
| mbcA | Rv2034 | Rv1990c | Rv2034 | Probable transcriptional regulatory protein; Antitoxin component of a type II toxin-antitoxin (TA) system. Neutralizes the activity of cognate toxin MbcT by blocking access to the toxin active site. | ArsR repressor protein; Involved in the regulation of lipid metabolism and hypoxic response. Positively regulates transcription of various genes, such as phoP, groEL2 and dosR. Negatively regulates its own transcription. Acts by binding to a specific palindromic sequence motif in promoter regions. | 0.644 |
| mbcA | higA2 | Rv1990c | Rv2021c | Probable transcriptional regulatory protein; Antitoxin component of a type II toxin-antitoxin (TA) system. Neutralizes the activity of cognate toxin MbcT by blocking access to the toxin active site. | Transcriptional regulatory protein; Putative antitoxin component of a type II toxin-antitoxin (TA) system. Its cognate toxin would be HigB2. | 0.533 |
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