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Rv2148c Rv2148c yfiH yfiH sepF sepF ftsZ ftsZ Rv2146c Rv2146c murF murF murC murC wag31 wag31 murG murG ftsQ ftsQ murX murX
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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textmining
co-expression
protein homology
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Rv2148cConserved protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis. (258 aa)    
Predicted Functional Partners:
yfiH
Conserved protein YfiH; Multicopper oxidase with polyphenol oxidase activity.
  
  
 0.978
sepF
Conserved hypothetical protein; Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.
  
  
 0.969
ftsZ
Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
  
  
 0.901
Rv2146c
Rv2146c, (MTCY270.22), len: 96 aa. Possible conserved transmembrane protein, orthologs present in M. leprae, ML0921 (96 aa) and Streptomyces coelicolor. Second start taken GTG alternative upstream but much less probable in TBParse. FASTA best: Q44935 similar to a hypothetical integral membrane prot EIN (97 aa) opt: 105, E(): 0.093; (25.3% identity in 87 aa overlap). >emb|CAC31302.1| (AL583920) possible membrane protein ML0921 [Mycobacterium leprae] E(): 5e-32 (76% identity in 96 aa overlap).
  
  
 0.812
murF
Probable UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate-D-alanyl-D-alanyl ligase MurF; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.
  
    0.793
murC
Probable UDP-N-acetylmuramate-alanine ligase MurC; Cell wall formation; Belongs to the MurCDEF family.
 
    0.772
wag31
Diviva family protein Wag31; Important for maintaining cell shape and cell wall integrity by localizing peptidoglycan synthesis to the cell poles. Protects PbpB (PBP3, FtsI) from oxidative stress-induced cleavage.
  
  
 0.745
murG
Undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II).
  
  
 0.724
ftsQ
Possible cell division protein FtsQ; Essential cell division protein.
  
  
 0.704
murX
Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.
  
  
 0.653
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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