STRINGSTRING
lppM lppM Rv2172c Rv2172c atpB atpB Rv0236A Rv0236A Rv2170 Rv2170 Rv2732c Rv2732c Rv3205c Rv3205c Rv0010c Rv0010c Rv1100 Rv1100 Rv0358 Rv0358 Rv0556 Rv0556
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lppMProbable conserved lipoprotein LppM; A putative lipoprotein that seems to be specialized for the initial steps of macrophage infection. A non-acylated fragment (residues 26-185) binds phosphatidyl-myo-inositol mannosides (PIMs). Limits, in a TLR2-dependent fashion, bacterial uptake by host (mouse); this effect may be mediated by nonacylated fragment 26-185. Plays a TLR2-dependent role in host phagosome maturation arrest. Plays a TLR2-independent role in chemokine production during the first 24 hours of mouse infection. (227 aa)    
Predicted Functional Partners:
Rv2172c
Conserved protein; Rv2172c, (MTV021.05c), len: 301 aa. Conserved protein, equivalent to Mycobacterium leprae conserved hypothetical protein ML0901 (304 aa). FASTA scores: opt: 1656, E(): 7.7e-98; 81.271% identity in 299 aa overlap (1-299:1-299) >emb|CAA18681.1| (AL022602) >gi|13092971|emb|CAC31282.1| (AL583920). A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004).
  
  
 0.881
atpB
Probable ATP synthase a chain AtpB (protein 6); Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. Belongs to the ATPase A chain family.
   
  
 0.821
Rv0236A
Rv0236A, len: 57 aa. Small secreted protein. A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004).
   
  
 0.805
Rv2170
GCN5-related N-acetyltransferase; Rv2170, (MTV021.03), len: 206 aa. Probable acetyltransferase. Contains GNAT (Gcn5-related N-acetyltransferase) domain in C-terminal part. See Vetting et al. 2005. Equivalent to hypothetical protein ML0903 (210 aa) from Mycobacterium leprae. FASTA scores: ML0903 conserved hypothetical protein (210 aa) opt: 1045, E(): 9.1e-57; 77.143% identity in 210 aa overlap. >emb|CAA18679.1| (AL022602) >gi|13092973|emb|CAC31284.1| (AL583920). A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004).
  
    0.775
Rv2732c
Rv2732c, (MTCY174.12c), len: 204 aa. Probable conserved transmembrane protein, similar to Q49834 hypothetical protein B2235_C1_155 from Mycobacterium leprae (209 aa), FASTA scores: opt: 932, E(): 0, (70.6% identity in 201 aa overlap). Contains PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004).
  
    0.763
Rv3205c
Conserved protein; Rv3205c, (MTCY07D11.21), len: 292 aa. Conserved protein, highly similar to Q9CCG7|ML0818 hypothetical protein from Mycobacterium leprae (297 aa), FASTA scores: opt: 1745, E(): 9.1e-98, (87.3% identity in 291 aa overlap). A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004).
 
    0.754
Rv0010c
Rv0010c, (MTCY10H4.10c), len: 141 aa. Probable conserved membrane protein. Belongs to superfamily DUF2581,conserved in the Actinomycetales. A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004).
  
    0.735
Rv1100
Conserved protein; Rv1100, (MTV017.53), len: 233 aa. Conserved protein,slightly similar to Rv1906c|MTCY180.12 hypothetical protein from Mycobacterium tuberculosis (156 aa), FASTA scores: opt: 122, E(): 6.9, (27.4% identity in 135 aa overlap). Equivalent to AL049491|MLCB1222_9 Mycobacterium leprae (257 aa) (63.8% identity in 257 aa overlap). A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004).
  
     0.720
Rv0358
Conserved protein; Rv0358, (MTCY13E10.20), len: 215 aa. Conserved protein, highly similar to ML0281|AL023514|MLCB4_14 conserved hypothetical protein from Mycobacterium leprae (229 aa), FASTA scores: opt: 852, E(): 0, (62.9% identity in 229 aa overlap). A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004).
  
    0.716
Rv0556
Rv0556, (MTCY25D10.35), len: 171 aa. Probable conserved transmembrane protein, equivalent to NP_302479.1|NC_002677 putative membrane protein from Mycobacterium leprae (175 aa). A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al.,2004).
  
    0.713
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.