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Rv2262c Rv2262c Rv2261c Rv2261c lspA lspA Rv2263 Rv2263 lpqG lpqG Rv3179 Rv3179 lgt lgt Rv1192 Rv1192 Rv3351c Rv3351c Rv1524 Rv1524 Rv2209 Rv2209
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
Rv2262cConserved hypothetical protein; Catalyzes the phospholipid dependent N-acylation of the N- terminal cysteine of apolipoprotein, the last step in lipoprotein maturation. (360 aa)    
Predicted Functional Partners:
Rv2261c
Rv2261c, (MTV022.11c), len: 140 aa. Conserved hypothetical protein, with function unknown but some similarity to C-terminal end of PCC6803 apolipoprotein N-acyltransferase from Synechocystis sp. Note that next ORF shows similarity to N-terminal part of P74055 apolipoprotein N-acyltransferase from Escherichia coli (519 aa), FASTA scores: opt: 142, E(): 0.007, (29.9% identity in 117 aa overlap), suggesting possible frameshift. Sequence of clones from two sources has been checked but no error found.
    0.991
lspA
Probable lipoprotein signal peptidase LspA; This protein specifically catalyzes the removal of signal peptides from prolipoproteins; Belongs to the peptidase A8 family.
 
  
 0.917
Rv2263
Rv2263, (MTV022.13), len: 317 aa. Possible oxidoreductase, similar to several oxidoreductases. Similarity suggests alternative GTG start at 10154 but then no rbs. FASTA scores: sptr|Q544 05|Q54405 probably an NADP-dependent oxidoreductase (297 aa) opt: 487, E(): 1.1e-23; (36.1% identity in 299 aa overlap). Also similar to Mycobacterium tuberculosis Rv0068, and Rv0439c; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  
  
 0.910
lpqG
Rv3623, (MTCY15C10.29c), len: 240 aa. Probable lpqG,conserved lipoprotein, showing some similarity with hypothetical proteins e.g. Q57432 from Methanosarcina barkeri (251 aa), FASTA scores: opt: 319, E(): 6.8e-12,(31.2% identity in 218 aa overlap); Q9PEA5|XF1123 outer membrane protein from Xylella fastidiosa (242 aa) FASTA scores: opt: 312, E(): 1.7e-11, (28.25% identity in 237 aa overlap); BAB49547|MLR2408 hypothetical protein from Rhizobium loti (Mesorhizobium loti) (236 aa), FASTA scores: opt: 304, E(): 5e-11, (27.05% identity in 244 aa overlap); etc. Has suitable signal peptide and [...]
   
  
 0.714
Rv3179
Conserved protein; Rv3179, (MTV014.23), len: 429 aa. Conserved protein,highly similar to Q9KH61 putative ATP/GTP binding protein from Mycobacterium smegmatis (428 aa), FASTA scores: opt: 2466, E(): 1.5e-148, (89.7% identity in 428 aa overlap) (no article found on the NCBI web site (July 2001)); and to other hypothetical bacterial proteins e.g. O07781|Rv0597c|MTCY19H5.25 from M. tuberculosis (411 aa),FASTA scores: opt: 1031, E(): 8e-58, (41.5% identity in 417 aa overlap); BAB54715|MLR9349 from Rhizobium loti (Mesorhizobium loti) (435 aa), FASTA scores: opt: 365, E(): 1.1e-15, (31.75% id [...]
      
 0.510
lgt
Possible prolipoprotein diacylglyceryl transferases Lgt; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family.
  
  
 0.507
Rv1192
Unknown protein; Rv1192, (MTCI364.04), len: 275 aa. Unknown protein,contains PS00120 lipases, serine active site.
  
  
 0.445
Rv3351c
Rv3351c, (MTV004.08c), len: 264 aa. Hypothetical protein, highly similar to C-terminal region (aa 292-479) of O53608|Rv0063|MTV030.06 oxidoreductase from Mycobacterium tuberculosis (479 aa), FASTA scores: opt: 699, E(): 1.7e-36, (54.75% identity in 190 aa overlap). Shows some similarity to Q9KYD6|SCD72A.20 putative lipoprotein (fragment) from Streptomyces coelicolor (403 aa), FASTA scores: opt: 192, E(): 9.1e-05, (27.9% identity in 154 aa overlap); and P71091|YGAK hypothetical 54.4 KDA protein from Bacillus subtilis (480 aa), FASTA scores: opt: 174, E(): 0.0014, (26.5% identity in 166 [...]
  
  
 0.438
Rv1524
Rv1524, (MTCY19G5.04c), len: 414 aa. Probable glycosyltransferase, similar to many e.g. P96559|U84349 glycosyltransferase GTFB from Amycolatopsis orientalis (407 aa), FASTA scores: opt: 363, E(): 6.2e-23, (28.8% identity in 430 aa overlap); also high similarity to Rv1526c|MTCY19G5.02 Mycobacterium tuberculosis hypothetical protein (58.7% identity in 416 aa overlap); and AF143772|AF143772_15 glycosyltransferase gtfB from Mycobacterium avium strain 215 (418 aa), FASTA scores: opt: 1801, E(): 0, (65.2% identity in 417 aa overlap).
   
  
 0.436
Rv2209
Rv2209, (MTCY190.20), len: 512 aa. Probable conserved integral membrane protein, similar to but longer than Rv0246 gp|AL021929|MTV 034_12 Mycobacterium tuberculosis (436 aa). FASTA score: opt: 712, E(): 2.8e-32; 33.4% identity in 422 aa overlap.
 
  
 0.431
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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