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lppO lppO sseB sseB mhpE mhpE lppH lppH Rv3467 Rv3467 Rv0094c Rv0094c Rv3669 Rv3669 Rv1810 Rv1810 Rv2650c Rv2650c lppK lppK lprB lprB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
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Coexpression
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[Homology]
Score
lppORv2290, (MTCY339.20c), len: 171 aa. Probable lppO,conserved lipoprotein, similar to Rv3763, 19KD_MYCTU P11572 19 kDa lipoprotein antigen precursor (159 aa) FASTA scores,opt: 119, E (): 1.3, (25.6% identity in 164 aa overlap). Contains appropriately positioned PS00013 lipoprotein motif (with one mismatch). This region is a possible MT-complex-specific genomic island (See Becq et al.,2007). (171 aa)    
Predicted Functional Partners:
sseB
Rv2291, (MTCY339.19c), len: 284 aa. Probable sseB,thiosulfate sulfurtransferase. Very similar to thiosulfate sulfurtransferas/rhodanese from Streptomyces coelicolor AL00920 4|SC9B10_21 (283 aa) opt: 765, E(): 0; Smith-Waterman score: 765; 46.9% identity in 286 aa overlap, similar to THTR_ECOLI P31142 putative thiosulfate sulfurtransferase (280 aa), FASTA scores, opt: 478, E(): 1e-23, (35.1% identity in 265 aa overlap).
  
  
 0.945
mhpE
Rv3469c, (MTCY13E12.22c), len: 336 aa. Probable mhpE, 4-hydroxy-2-oxovalerate aldolase, similar to others (principally from Pseudomonas species) e.g. Q99PZ1|SCP1.301|SCP1.53c from Streptomyces coelicolor (338 aa), FASTA scores: opt: 615, E(): 7.9e-31, (37.65% identity in 332 aa overlap); Q9X9Q0|NIKB NIKB protein (see Bruntner et al., 1999) from Streptomyces tendae (357 aa), FASTA scores: opt: 571, E(): 4.4e-28, (34.5% identity in 339 aa overlap); P51014|BPHF_PSES1 from Pseudomonas sp. strain KKS102 (352 aa), FASTA scores: opt: 549, E(): 9.9e-27,(31.2% identity in 314 aa overlap); Q5198 [...]
   
  
 0.907
lppH
Rv3576, (MTCY06G11.23), len: 237 aa. Possible lppH,conserved lipoprotein, similar in part with proteins from Mycobacterium tuberculosis; C-terminus of Q11053|PKNH_MYCTU|PKNH|Rv1266c|MT1304|MTCY50.16 probable serine/threonine-protein kinase (626 aa) FASTA scores: opt: 396, E(): 6.5e-19, (36.0% identity in 200 aa overlap); and with P71740|LPPR|Rv2403c|MTCY253.17 probable lipoprotein protein (251 aa), FASTA scores: opt: 134, E(): 0.087,(22.7% identity in 207 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Note that previously known as pknM.
   
  
 0.860
Rv3467
Rv3467, (MTCY13E12.20), len: 317 aa. Conserved hypothetical ORF in REP13E12 repeat, identical to ORF's from other REP13E12 copies e.g. MTCY251.13c, MTCI65.15c,MTCY09F9.19, cMTCY336.17. Also identical to Mycobacterium bovis Q50655 hypothetical 34.6 kDa protein (317 aa) in identical repeat.
   
  
 0.811
Rv0094c
Conserved hypothetical protein; Rv0094c, (MTCY251.13c), len: 317 aa. Member of 13E12 repeat family, showing some similarity to U15187|MLU15187_7 from Mycobacterium leprae (94 aa), FASTA score: (49.4% identity in 79 aa overlap).
   
  
 0.810
Rv3669
Rv3669, (MTV025.017), len: 172 aa. Probable conserved transmembrane protein, equivalent to Q9CB97|ML2296 putative membrane protein from Mycobacterium leprae (181 aa), FASTA scores: opt: 863, E(): 1.4e-47,(77.35% identity in 181 aa overlap). Also similar to two putative integral membrane transport proteins from Streptomyces coelicolor; Q9X930|SCH5.28 (162 aa) FASTA scores: opt: 265, E(): 6.3e-10, (37.4% identity in 155 aa overlap); and Q9X9W1|SCI7.29c (165 aa), FASTA scores: opt: 194, E(): 1.9e-05, (30.6% identity in 134 aa overlap). Contains two hydrophobic stretches in centre.
   
  
 0.807
Rv1810
Conserved protein; Rv1810, (MTCY16F9.04c), len: 118 aa. Conserved protein, similar to several hypothetical Mycobacterium tuberculosis proteins that may be exported (possible N-terminal signal sequence) e.g. O53953|Rv1804c|MTV049.26c|AL022021 (108 aa), FASTA scores: opt: 361, E(): 9.6e-17, (53.5% identity in 101 aa overlap); Rv0622, and Rv1690, etc.
   
  
 0.805
Rv2650c
Rv2650c, (MTCY441.19), len: 479 aa. Possible phiRv2 prophage protein (capsid subunit) (see citation below),highly similar to O06614|Rv1576c|MTCY336.28 probable phiRv1 phage protein from Mycobacterium tuberculosis (473 aa),FASTA scores: opt: 2782, E(): 2.8e-159, (89.1% identity in 468 aa overlap).
      
 0.803
lppK
Rv2116, (MTCY261.12), len: 189 aa. LppK, conserved lipoprotein, similar to many. Contains N-terminal signal sequence and PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Some similarity to Rv2376c. A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004).
   
  
 0.705
lprB
Rv1274, (MTCY50.08c), len: 185 aa. Possible lprB,lipoprotein; contains possible N-terminal signal sequence and appropriately positioned prokaryotic lipoprotein lipid attachment site (PS00013). Some similarity to Rv1275. A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004).
   
  
 0.682
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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