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rocD1 rocD1 rocD2 rocD2 Rv2323c Rv2323c rocE rocE Rv2319c Rv2319c rocA rocA proB proB argG argG argB argB argC argC argH argH
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
rocD1Rv2322c, (MTCY3G12.12), len: 221 aa. Probable rocD1,ornithine aminotransferase, highly similar to N-terminal region of other ornithine aminotransferases, e.g. Q9FC90|ROCD from Streptomyces coelicolor (407 aa), FASTA scores: opt: 770, E(): 8.7e-40, (55.7% identity in 201 aa overlap); BAB42057|ROCD|SA0818 from Staphylococcus aureus subsp. aureus N315 (396 aa) FASTA scores: opt: 632, E(): 2.2e-31, (46.1% identity in 208 aa overlap); P38021|OAT_BACSU|ROCD from Bacillus subtilis (401 aa),FASTA scores: opt: 626, E(): 5.1e-31, (43.1% identity in 218 aa overlap); etc. Belongs to class-III of p [...] (221 aa)    
Predicted Functional Partners:
rocD2
Rv2321c, (MTCY3G12.13), len: 181 aa. Probable rocD2,ornithine aminotransferase, highly similar to C-terminal region of other ornithine aminotransferases, e.g. Q9FC90|ROCD from Streptomyces coelicolor (407 aa), FASTA scores: opt: 628, E(): 1.2e-32, (55.35% identity in 168 aa overlap); P3802|OAT_BACSU|ROCD from Bacillus subtilis (401 aa), FASTA scores: opt: 477, E(): 4.3e-23, (42.1% identity in 178 aa overlap); BAB42057|ROCD|SA0818 from Staphylococcus aureus subsp. aureus N315 (396 aa), FASTA scores: opt: 437, E(): 1.5e-20, (41.3% identity in 170 aa overlap); etc. Contains PS00600 Aminot [...]
    0.999
Rv2323c
Conserved protein; Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)- monomethyl-L-arginine (MMA); Belongs to the DDAH family.
  
 0.984
rocE
Rv2320c, (MTCY3G12.14), len: 476 aa. Probable rocE,cationic amino acid (especially arginine and ornithine) transporter (permease), highly similar to other amino acid transporters e.g. Q9L100|SCL6.16C putative amino acid transporter from Streptomyces coelicolor (496 aa), FASTA scores: opt: 1485, E(): 9.4e-82, (48.4% identity in 477 aa overlap); O06479|YFNA putative amino acid transporter from Bacillus subtilis (462 aa), FASTA scores: opt: 1271, E(): 6.1e-69, (41.9% identity in 463 aa overlap); Q9PG94|XF0408 amino acid transporter from Xylella fastidiosa (509 aa),FASTA scores: opt: 1128, [...]
  
 
 0.975
Rv2319c
Rv2319c, (MTCY3G12.15), len: 292 aa. Universal stress protein family protein.
  
  
 0.962
rocA
Rv1187, (MTV005.23), len: 543 aa. Probable rocA,pyrroline-5-carboxylate dehydrogenase, similar to many e.g. PUT2_HUMAN|P30038 human delta-1-pyrroline-5-carboxylate dehydrogenase (563 aa), FASTA scores: opt: 1596, E():0,(46.0% identity in 531 aa overlap). Also similar to other Mycobacterium tuberculosis hypothetical dehydrogenases e.g. Rv0768, Rv2858c, etc. Contains PS00687 Aldehyde dehydrogenases glutamic acid active site and PS00070 Aldehyde dehydrogenases cysteine active site.
 
 0.941
proB
Probable glutamate 5-kinase protein ProB (gamma-glutamyl kinase) (GK); Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
   
 0.923
argG
Rv1658, (MTCY06H11.23), len: 398 aa. Probable argG,Argininosuccinate synthase, similar to ASSY_STRCL|P50986 argininosuccinate synthase from Streptomyces clavuligerus (397 aa), FASTA scores: opt: 1873, E(): 0, (67.8% identity in 397 aa overlap); contains PS00564 Argininosuccinate synthase signature 1, PS00565 Argininosuccinate synthase signature 2. Belongs to the argininosuccinate synthase family.
 
 
 0.832
argB
Probable acetylglutamate kinase ArgB; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate.
 
  
 0.817
argC
Probable N-acetyl-gamma-glutamyl-phoshate reductase ArgC; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
 
  
 0.812
argH
Rv1659, (MTCY06H11.24), len: 470 aa. Probable argH,Argininosuccinate lyase, similar to ARLY_ECOLI|P11447 argininosuccinate lyase from Escherichia coli (457 aa),FASTA scores: opt: 1091, E(): 0, (42.5% identity in 461 aa overlap); contains PS00017 ATP/GTP-binding site motif A,PS00163 Fumarate lyases signature. Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
 
  
 0.808
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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