node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rv2331 | Rv2331A | Rv2331 | Rv2331A | Hypothetical protein; Rv2331, (MT2393, MTCY3G12.03c), len: 128 aa. Hypothetical unknown protein; shortened version of MTCY3G12.03c to eliminate overlap with MTCY3G12.04. | Rv2331A, len: 112 aa. Hypothetical unknown protein. | 0.637 |
Rv2331 | lppP | Rv2331 | Rv2330c | Hypothetical protein; Rv2331, (MT2393, MTCY3G12.03c), len: 128 aa. Hypothetical unknown protein; shortened version of MTCY3G12.03c to eliminate overlap with MTCY3G12.04. | Rv2330c, (MTCY3G12.04), len: 175 aa. Probable lppP,lipoprotein. Contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. | 0.606 |
Rv2331 | mez | Rv2331 | Rv2332 | Hypothetical protein; Rv2331, (MT2393, MTCY3G12.03c), len: 128 aa. Hypothetical unknown protein; shortened version of MTCY3G12.03c to eliminate overlap with MTCY3G12.04. | Putative malate oxidoreductase [NAD]; Rv2332, (MTCY3G12.02c, MTCY98.01, MT2394), len: 548 aa. Probable mez, malate oxidoreductase [NAD] dependent (malic enzyme), highly similar to others e.g. O34389|MALS putative malolactic enzyme [includes: malic enzyme; L-lactate dehydrogenase] from Bacillus subtilis (566 aa),FASTA scores: opt: 1927, E(): 5.5e-111, (52.9% identity in 539 aa overlap); P45868|MAO2_BACSU|YWKA probable NAD-dependent malic enzyme from Bacillus subtilis (582 aa),FASTA scores: opt: 1849, E(): 3.6e-106, (50.45% identity in 543 aa overlap); Q48796|MLES_OENOE malolactic enzyme [...] | 0.538 |
Rv2331A | Rv2331 | Rv2331A | Rv2331 | Rv2331A, len: 112 aa. Hypothetical unknown protein. | Hypothetical protein; Rv2331, (MT2393, MTCY3G12.03c), len: 128 aa. Hypothetical unknown protein; shortened version of MTCY3G12.03c to eliminate overlap with MTCY3G12.04. | 0.637 |
Rv2331A | lppP | Rv2331A | Rv2330c | Rv2331A, len: 112 aa. Hypothetical unknown protein. | Rv2330c, (MTCY3G12.04), len: 175 aa. Probable lppP,lipoprotein. Contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. | 0.445 |
Rv2331A | mez | Rv2331A | Rv2332 | Rv2331A, len: 112 aa. Hypothetical unknown protein. | Putative malate oxidoreductase [NAD]; Rv2332, (MTCY3G12.02c, MTCY98.01, MT2394), len: 548 aa. Probable mez, malate oxidoreductase [NAD] dependent (malic enzyme), highly similar to others e.g. O34389|MALS putative malolactic enzyme [includes: malic enzyme; L-lactate dehydrogenase] from Bacillus subtilis (566 aa),FASTA scores: opt: 1927, E(): 5.5e-111, (52.9% identity in 539 aa overlap); P45868|MAO2_BACSU|YWKA probable NAD-dependent malic enzyme from Bacillus subtilis (582 aa),FASTA scores: opt: 1849, E(): 3.6e-106, (50.45% identity in 543 aa overlap); Q48796|MLES_OENOE malolactic enzyme [...] | 0.733 |
fadE36 | lppP | Rv3761c | Rv2330c | Rv3761c, (MTV025.109c), len: 351 aa. Possible fadE36, acyl-CoA dehydrogenase, similar to many conserved hypothetical proteins and showing some similarity with few acyl-CoA dehydrogenases, e.g. Q9APX7|FADE36 FADE36 protein from Pseudomonas aeruginosa (360 aa), FASTA scores: opt: 147, E(): 0.046, (26.15% identity in 214 aa overlap); part of AAB52261.2|U97002 protein similar to acyl-CoA dehydrogenases and epoxide hydrolases from Caenorhabditis elegans (985 aa), FASTA score: (31.2% identity in 324 aa overlap). C-terminal part is highly similar to Q50095|U1740AK|MLU15183_45 hypothetical pro [...] | Rv2330c, (MTCY3G12.04), len: 175 aa. Probable lppP,lipoprotein. Contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. | 0.414 |
lppP | Rv2331 | Rv2330c | Rv2331 | Rv2330c, (MTCY3G12.04), len: 175 aa. Probable lppP,lipoprotein. Contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. | Hypothetical protein; Rv2331, (MT2393, MTCY3G12.03c), len: 128 aa. Hypothetical unknown protein; shortened version of MTCY3G12.03c to eliminate overlap with MTCY3G12.04. | 0.606 |
lppP | Rv2331A | Rv2330c | Rv2331A | Rv2330c, (MTCY3G12.04), len: 175 aa. Probable lppP,lipoprotein. Contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. | Rv2331A, len: 112 aa. Hypothetical unknown protein. | 0.445 |
lppP | fadE36 | Rv2330c | Rv3761c | Rv2330c, (MTCY3G12.04), len: 175 aa. Probable lppP,lipoprotein. Contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. | Rv3761c, (MTV025.109c), len: 351 aa. Possible fadE36, acyl-CoA dehydrogenase, similar to many conserved hypothetical proteins and showing some similarity with few acyl-CoA dehydrogenases, e.g. Q9APX7|FADE36 FADE36 protein from Pseudomonas aeruginosa (360 aa), FASTA scores: opt: 147, E(): 0.046, (26.15% identity in 214 aa overlap); part of AAB52261.2|U97002 protein similar to acyl-CoA dehydrogenases and epoxide hydrolases from Caenorhabditis elegans (985 aa), FASTA score: (31.2% identity in 324 aa overlap). C-terminal part is highly similar to Q50095|U1740AK|MLU15183_45 hypothetical pro [...] | 0.414 |
lppP | lprN | Rv2330c | Rv3495c | Rv2330c, (MTCY3G12.04), len: 175 aa. Probable lppP,lipoprotein. Contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. | Possible Mce-family lipoprotein LprN (Mce-family lipoprotein Mce4E); Stimulates the host (mouse) immune response; lipidated protein produced in E.coli stimulates T-cell proliferation in mice previously sensitized with LprN. Spleenocytes from these mice produce increased amounts of TNF-alpha and IFN-gamma, as well as somewhat increased nitric oxide levels, upon subsequent challenge with LprN. Previously sensitized mice infected with M.tuberculosis have an exacerbated disease response, suggesting this lipoprotein may down- regulate the host's immune response. | 0.637 |
lppP | lprO | Rv2330c | Rv0179c | Rv2330c, (MTCY3G12.04), len: 175 aa. Probable lppP,lipoprotein. Contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. | Rv0179c, (MTCI28.19c), len: 369 aa. Possible lprO,lipoprotein (visibly not conserved). Contains possible N-terminal signal sequence and PS00013 Prokaryotic membrane lipoprotein lipid attachment site. | 0.616 |
lppP | mez | Rv2330c | Rv2332 | Rv2330c, (MTCY3G12.04), len: 175 aa. Probable lppP,lipoprotein. Contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. | Putative malate oxidoreductase [NAD]; Rv2332, (MTCY3G12.02c, MTCY98.01, MT2394), len: 548 aa. Probable mez, malate oxidoreductase [NAD] dependent (malic enzyme), highly similar to others e.g. O34389|MALS putative malolactic enzyme [includes: malic enzyme; L-lactate dehydrogenase] from Bacillus subtilis (566 aa),FASTA scores: opt: 1927, E(): 5.5e-111, (52.9% identity in 539 aa overlap); P45868|MAO2_BACSU|YWKA probable NAD-dependent malic enzyme from Bacillus subtilis (582 aa),FASTA scores: opt: 1849, E(): 3.6e-106, (50.45% identity in 543 aa overlap); Q48796|MLES_OENOE malolactic enzyme [...] | 0.400 |
lppP | narK1 | Rv2330c | Rv2329c | Rv2330c, (MTCY3G12.04), len: 175 aa. Probable lppP,lipoprotein. Contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. | Rv2329c, (MTCY3G12.05), len: 515 aa. Probable narK1,nitrite extrusion protein, possibly member of major facilitator superfamily (MFS). Equivalent to O32974|MLCB22.41c|nark|ML0844 putative nitrite extrusion protein from Mycobacterium leprae (517 aa), FASTA scores: opt: 2224, E(): 1.9e-129, (69.3% identity in 488 aa overlap). Also highly similar to others e.g. P94933 nitrite extrusion protein from Mycobacterium fortuitum (471 aa),FASTA scores: opt: 1969, E(): 8.6e-114, (62.1% identity in 459 aa overlap); P37758|NARU_ECOLI nitrite extrusion protein 2 from Escherichia coli strain K12 (462 [...] | 0.449 |
lprN | lppP | Rv3495c | Rv2330c | Possible Mce-family lipoprotein LprN (Mce-family lipoprotein Mce4E); Stimulates the host (mouse) immune response; lipidated protein produced in E.coli stimulates T-cell proliferation in mice previously sensitized with LprN. Spleenocytes from these mice produce increased amounts of TNF-alpha and IFN-gamma, as well as somewhat increased nitric oxide levels, upon subsequent challenge with LprN. Previously sensitized mice infected with M.tuberculosis have an exacerbated disease response, suggesting this lipoprotein may down- regulate the host's immune response. | Rv2330c, (MTCY3G12.04), len: 175 aa. Probable lppP,lipoprotein. Contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. | 0.637 |
lprN | lprO | Rv3495c | Rv0179c | Possible Mce-family lipoprotein LprN (Mce-family lipoprotein Mce4E); Stimulates the host (mouse) immune response; lipidated protein produced in E.coli stimulates T-cell proliferation in mice previously sensitized with LprN. Spleenocytes from these mice produce increased amounts of TNF-alpha and IFN-gamma, as well as somewhat increased nitric oxide levels, upon subsequent challenge with LprN. Previously sensitized mice infected with M.tuberculosis have an exacerbated disease response, suggesting this lipoprotein may down- regulate the host's immune response. | Rv0179c, (MTCI28.19c), len: 369 aa. Possible lprO,lipoprotein (visibly not conserved). Contains possible N-terminal signal sequence and PS00013 Prokaryotic membrane lipoprotein lipid attachment site. | 0.636 |
lprO | lppP | Rv0179c | Rv2330c | Rv0179c, (MTCI28.19c), len: 369 aa. Possible lprO,lipoprotein (visibly not conserved). Contains possible N-terminal signal sequence and PS00013 Prokaryotic membrane lipoprotein lipid attachment site. | Rv2330c, (MTCY3G12.04), len: 175 aa. Probable lppP,lipoprotein. Contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. | 0.616 |
lprO | lprN | Rv0179c | Rv3495c | Rv0179c, (MTCI28.19c), len: 369 aa. Possible lprO,lipoprotein (visibly not conserved). Contains possible N-terminal signal sequence and PS00013 Prokaryotic membrane lipoprotein lipid attachment site. | Possible Mce-family lipoprotein LprN (Mce-family lipoprotein Mce4E); Stimulates the host (mouse) immune response; lipidated protein produced in E.coli stimulates T-cell proliferation in mice previously sensitized with LprN. Spleenocytes from these mice produce increased amounts of TNF-alpha and IFN-gamma, as well as somewhat increased nitric oxide levels, upon subsequent challenge with LprN. Previously sensitized mice infected with M.tuberculosis have an exacerbated disease response, suggesting this lipoprotein may down- regulate the host's immune response. | 0.636 |
mez | Rv2331 | Rv2332 | Rv2331 | Putative malate oxidoreductase [NAD]; Rv2332, (MTCY3G12.02c, MTCY98.01, MT2394), len: 548 aa. Probable mez, malate oxidoreductase [NAD] dependent (malic enzyme), highly similar to others e.g. O34389|MALS putative malolactic enzyme [includes: malic enzyme; L-lactate dehydrogenase] from Bacillus subtilis (566 aa),FASTA scores: opt: 1927, E(): 5.5e-111, (52.9% identity in 539 aa overlap); P45868|MAO2_BACSU|YWKA probable NAD-dependent malic enzyme from Bacillus subtilis (582 aa),FASTA scores: opt: 1849, E(): 3.6e-106, (50.45% identity in 543 aa overlap); Q48796|MLES_OENOE malolactic enzyme [...] | Hypothetical protein; Rv2331, (MT2393, MTCY3G12.03c), len: 128 aa. Hypothetical unknown protein; shortened version of MTCY3G12.03c to eliminate overlap with MTCY3G12.04. | 0.538 |
mez | Rv2331A | Rv2332 | Rv2331A | Putative malate oxidoreductase [NAD]; Rv2332, (MTCY3G12.02c, MTCY98.01, MT2394), len: 548 aa. Probable mez, malate oxidoreductase [NAD] dependent (malic enzyme), highly similar to others e.g. O34389|MALS putative malolactic enzyme [includes: malic enzyme; L-lactate dehydrogenase] from Bacillus subtilis (566 aa),FASTA scores: opt: 1927, E(): 5.5e-111, (52.9% identity in 539 aa overlap); P45868|MAO2_BACSU|YWKA probable NAD-dependent malic enzyme from Bacillus subtilis (582 aa),FASTA scores: opt: 1849, E(): 3.6e-106, (50.45% identity in 543 aa overlap); Q48796|MLES_OENOE malolactic enzyme [...] | Rv2331A, len: 112 aa. Hypothetical unknown protein. | 0.733 |