node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rv0183 | Rv2417c | Rv0183 | Rv2417c | Possible lysophospholipase; Involved in the hydrolysis of exogenous host lipids during chronic infection. Catalyzes the hydrolysis of both monoacylglycerols (MAG) and diacylglycerols (DAG). It hydrolyzes 2-MAG, 1-3-MAG and MAG with short, medium and long chain fatty acids such as 1-monobutyroyl- rac-glycerol (MC4), 1-mono-octanoyl-rac-glycerol (MC8), 1-monodecanoyl- rac-glycerol (MC10), 1-monolauroyl-rac-glycerol (MC12), 1- monomyristoyl-rac-glycerol (MC14) and 1-mono-oleyl-rac-glycerol (MC18:1). Also able to hydrolyze DAG with short (DiC6) and medium (DiC10) fatty acid chains, but not [...] | Conserved protein; May bind long-chain fatty acids, such as palmitate, and may play a role in lipid transport or fatty acid metabolism. | 0.811 |
Rv0183 | gpgP | Rv0183 | Rv2419c | Possible lysophospholipase; Involved in the hydrolysis of exogenous host lipids during chronic infection. Catalyzes the hydrolysis of both monoacylglycerols (MAG) and diacylglycerols (DAG). It hydrolyzes 2-MAG, 1-3-MAG and MAG with short, medium and long chain fatty acids such as 1-monobutyroyl- rac-glycerol (MC4), 1-mono-octanoyl-rac-glycerol (MC8), 1-monodecanoyl- rac-glycerol (MC10), 1-monolauroyl-rac-glycerol (MC12), 1- monomyristoyl-rac-glycerol (MC14) and 1-mono-oleyl-rac-glycerol (MC18:1). Also able to hydrolyze DAG with short (DiC6) and medium (DiC10) fatty acid chains, but not [...] | Glucosyl-3-phosphoglycerate phosphatase GpgP; Involved in the biosynthesis of mycobacterial methylglucose lipopolysaccharides (MGLPs). Catalyzes the dephosphorylation of glucosyl-3-phosphoglycerate (GPG) to glucosylglycerate (GG). GPG is the preferred substrate, but GpgP also exhibits low dephosphorylation activity on mannosyl-3-phosphoglycerate (MPG) and mannosylglucosyl-3- phosphoglycerate (MGPG) in vitro. Shows only trace of phosphoglycerate mutase (PGM) activity. | 0.553 |
Rv0183 | octT | Rv0183 | Rv2418c | Possible lysophospholipase; Involved in the hydrolysis of exogenous host lipids during chronic infection. Catalyzes the hydrolysis of both monoacylglycerols (MAG) and diacylglycerols (DAG). It hydrolyzes 2-MAG, 1-3-MAG and MAG with short, medium and long chain fatty acids such as 1-monobutyroyl- rac-glycerol (MC4), 1-mono-octanoyl-rac-glycerol (MC8), 1-monodecanoyl- rac-glycerol (MC10), 1-monolauroyl-rac-glycerol (MC12), 1- monomyristoyl-rac-glycerol (MC14) and 1-mono-oleyl-rac-glycerol (MC18:1). Also able to hydrolyze DAG with short (DiC6) and medium (DiC10) fatty acid chains, but not [...] | Unknown protein; Sugar octanoyltransferase likely involved in the biosynthesis of mycobacterial methylglucose lipopolysaccharide (MGLP). Catalyzes the transfer of an octanoyl group from octanoyl-CoA to the C6 OH of the second glucose in diglucosylglycerate (DGG). DGG is the preferred acceptor, but to a lesser extent, GG (glucosylglycerate) can also be used as substrate. DGG and GG are the two earliest intermediates in MGLP biosynthesis. | 0.821 |
Rv2417c | Rv0183 | Rv2417c | Rv0183 | Conserved protein; May bind long-chain fatty acids, such as palmitate, and may play a role in lipid transport or fatty acid metabolism. | Possible lysophospholipase; Involved in the hydrolysis of exogenous host lipids during chronic infection. Catalyzes the hydrolysis of both monoacylglycerols (MAG) and diacylglycerols (DAG). It hydrolyzes 2-MAG, 1-3-MAG and MAG with short, medium and long chain fatty acids such as 1-monobutyroyl- rac-glycerol (MC4), 1-mono-octanoyl-rac-glycerol (MC8), 1-monodecanoyl- rac-glycerol (MC10), 1-monolauroyl-rac-glycerol (MC12), 1- monomyristoyl-rac-glycerol (MC14) and 1-mono-oleyl-rac-glycerol (MC18:1). Also able to hydrolyze DAG with short (DiC6) and medium (DiC10) fatty acid chains, but not [...] | 0.811 |
Rv2417c | Rv3030 | Rv2417c | Rv3030 | Conserved protein; May bind long-chain fatty acids, such as palmitate, and may play a role in lipid transport or fatty acid metabolism. | Conserved protein; Probable S-adenosylmethionine-dependent methyltransferase required for the 6-O-methylation of the polysaccharide backbone of 6-O- methylglucosyl lipopolysaccharides (MGLP). | 0.437 |
Rv2417c | Rv3034c | Rv2417c | Rv3034c | Conserved protein; May bind long-chain fatty acids, such as palmitate, and may play a role in lipid transport or fatty acid metabolism. | Possible transferase; Putative acetyltransferase that is probably involved in the biosynthesis of 6-O-methylglucosyl lipopolysaccharides (MGLP). | 0.439 |
Rv2417c | gpgP | Rv2417c | Rv2419c | Conserved protein; May bind long-chain fatty acids, such as palmitate, and may play a role in lipid transport or fatty acid metabolism. | Glucosyl-3-phosphoglycerate phosphatase GpgP; Involved in the biosynthesis of mycobacterial methylglucose lipopolysaccharides (MGLPs). Catalyzes the dephosphorylation of glucosyl-3-phosphoglycerate (GPG) to glucosylglycerate (GG). GPG is the preferred substrate, but GpgP also exhibits low dephosphorylation activity on mannosyl-3-phosphoglycerate (MPG) and mannosylglucosyl-3- phosphoglycerate (MGPG) in vitro. Shows only trace of phosphoglycerate mutase (PGM) activity. | 0.976 |
Rv2417c | nadD | Rv2417c | Rv2421c | Conserved protein; May bind long-chain fatty acids, such as palmitate, and may play a role in lipid transport or fatty acid metabolism. | Probable nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.794 |
Rv2417c | octT | Rv2417c | Rv2418c | Conserved protein; May bind long-chain fatty acids, such as palmitate, and may play a role in lipid transport or fatty acid metabolism. | Unknown protein; Sugar octanoyltransferase likely involved in the biosynthesis of mycobacterial methylglucose lipopolysaccharide (MGLP). Catalyzes the transfer of an octanoyl group from octanoyl-CoA to the C6 OH of the second glucose in diglucosylglycerate (DGG). DGG is the preferred acceptor, but to a lesser extent, GG (glucosylglycerate) can also be used as substrate. DGG and GG are the two earliest intermediates in MGLP biosynthesis. | 0.973 |
Rv2417c | rsfS | Rv2417c | Rv2420c | Conserved protein; May bind long-chain fatty acids, such as palmitate, and may play a role in lipid transport or fatty acid metabolism. | Conserved hypothetical protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. Belongs to the Iojap/RsfS family. | 0.787 |
Rv3030 | Rv2417c | Rv3030 | Rv2417c | Conserved protein; Probable S-adenosylmethionine-dependent methyltransferase required for the 6-O-methylation of the polysaccharide backbone of 6-O- methylglucosyl lipopolysaccharides (MGLP). | Conserved protein; May bind long-chain fatty acids, such as palmitate, and may play a role in lipid transport or fatty acid metabolism. | 0.437 |
Rv3030 | Rv3031 | Rv3030 | Rv3031 | Conserved protein; Probable S-adenosylmethionine-dependent methyltransferase required for the 6-O-methylation of the polysaccharide backbone of 6-O- methylglucosyl lipopolysaccharides (MGLP). | Conserved protein; Catalyzes the formation of branch points in alpha-glucans by cleavage of an alpha-1,4 glycosidic bond and subsequent transfer of the cleaved-off oligosaccharide to a new alpha-1,6 position (Probable). Is probably involved in the biosynthesis of 6-O-methylglucosyl lipopolysaccharides (MGLP); Belongs to the glycosyl hydrolase 57 family. | 0.991 |
Rv3030 | Rv3032 | Rv3030 | Rv3032 | Conserved protein; Probable S-adenosylmethionine-dependent methyltransferase required for the 6-O-methylation of the polysaccharide backbone of 6-O- methylglucosyl lipopolysaccharides (MGLP). | Alpha (1->4) glucosyltransferase; Glucosyltransferase that uses UDP-glucose as the sugar donor to elongate alpha-(1->4)-glucans. Is involved in the biosynthesis of both 6-O-methylglucosyl lipopolysaccharides (MGLP) and glycogen. May also use ADP-glucose as substrate. | 0.991 |
Rv3030 | Rv3034c | Rv3030 | Rv3034c | Conserved protein; Probable S-adenosylmethionine-dependent methyltransferase required for the 6-O-methylation of the polysaccharide backbone of 6-O- methylglucosyl lipopolysaccharides (MGLP). | Possible transferase; Putative acetyltransferase that is probably involved in the biosynthesis of 6-O-methylglucosyl lipopolysaccharides (MGLP). | 0.953 |
Rv3030 | gpgP | Rv3030 | Rv2419c | Conserved protein; Probable S-adenosylmethionine-dependent methyltransferase required for the 6-O-methylation of the polysaccharide backbone of 6-O- methylglucosyl lipopolysaccharides (MGLP). | Glucosyl-3-phosphoglycerate phosphatase GpgP; Involved in the biosynthesis of mycobacterial methylglucose lipopolysaccharides (MGLPs). Catalyzes the dephosphorylation of glucosyl-3-phosphoglycerate (GPG) to glucosylglycerate (GG). GPG is the preferred substrate, but GpgP also exhibits low dephosphorylation activity on mannosyl-3-phosphoglycerate (MPG) and mannosylglucosyl-3- phosphoglycerate (MGPG) in vitro. Shows only trace of phosphoglycerate mutase (PGM) activity. | 0.803 |
Rv3030 | octT | Rv3030 | Rv2418c | Conserved protein; Probable S-adenosylmethionine-dependent methyltransferase required for the 6-O-methylation of the polysaccharide backbone of 6-O- methylglucosyl lipopolysaccharides (MGLP). | Unknown protein; Sugar octanoyltransferase likely involved in the biosynthesis of mycobacterial methylglucose lipopolysaccharide (MGLP). Catalyzes the transfer of an octanoyl group from octanoyl-CoA to the C6 OH of the second glucose in diglucosylglycerate (DGG). DGG is the preferred acceptor, but to a lesser extent, GG (glucosylglycerate) can also be used as substrate. DGG and GG are the two earliest intermediates in MGLP biosynthesis. | 0.925 |
Rv3031 | Rv3030 | Rv3031 | Rv3030 | Conserved protein; Catalyzes the formation of branch points in alpha-glucans by cleavage of an alpha-1,4 glycosidic bond and subsequent transfer of the cleaved-off oligosaccharide to a new alpha-1,6 position (Probable). Is probably involved in the biosynthesis of 6-O-methylglucosyl lipopolysaccharides (MGLP); Belongs to the glycosyl hydrolase 57 family. | Conserved protein; Probable S-adenosylmethionine-dependent methyltransferase required for the 6-O-methylation of the polysaccharide backbone of 6-O- methylglucosyl lipopolysaccharides (MGLP). | 0.991 |
Rv3031 | Rv3032 | Rv3031 | Rv3032 | Conserved protein; Catalyzes the formation of branch points in alpha-glucans by cleavage of an alpha-1,4 glycosidic bond and subsequent transfer of the cleaved-off oligosaccharide to a new alpha-1,6 position (Probable). Is probably involved in the biosynthesis of 6-O-methylglucosyl lipopolysaccharides (MGLP); Belongs to the glycosyl hydrolase 57 family. | Alpha (1->4) glucosyltransferase; Glucosyltransferase that uses UDP-glucose as the sugar donor to elongate alpha-(1->4)-glucans. Is involved in the biosynthesis of both 6-O-methylglucosyl lipopolysaccharides (MGLP) and glycogen. May also use ADP-glucose as substrate. | 0.999 |
Rv3031 | Rv3034c | Rv3031 | Rv3034c | Conserved protein; Catalyzes the formation of branch points in alpha-glucans by cleavage of an alpha-1,4 glycosidic bond and subsequent transfer of the cleaved-off oligosaccharide to a new alpha-1,6 position (Probable). Is probably involved in the biosynthesis of 6-O-methylglucosyl lipopolysaccharides (MGLP); Belongs to the glycosyl hydrolase 57 family. | Possible transferase; Putative acetyltransferase that is probably involved in the biosynthesis of 6-O-methylglucosyl lipopolysaccharides (MGLP). | 0.924 |
Rv3031 | gpgP | Rv3031 | Rv2419c | Conserved protein; Catalyzes the formation of branch points in alpha-glucans by cleavage of an alpha-1,4 glycosidic bond and subsequent transfer of the cleaved-off oligosaccharide to a new alpha-1,6 position (Probable). Is probably involved in the biosynthesis of 6-O-methylglucosyl lipopolysaccharides (MGLP); Belongs to the glycosyl hydrolase 57 family. | Glucosyl-3-phosphoglycerate phosphatase GpgP; Involved in the biosynthesis of mycobacterial methylglucose lipopolysaccharides (MGLPs). Catalyzes the dephosphorylation of glucosyl-3-phosphoglycerate (GPG) to glucosylglycerate (GG). GPG is the preferred substrate, but GpgP also exhibits low dephosphorylation activity on mannosyl-3-phosphoglycerate (MPG) and mannosylglucosyl-3- phosphoglycerate (MGPG) in vitro. Shows only trace of phosphoglycerate mutase (PGM) activity. | 0.405 |