STRINGSTRING
Rv2491 Rv2491 Rv2492 Rv2492 purF purF log log pyrH pyrH Rv2017 Rv2017 vapB38 vapB38 vapC38 vapC38 nrdZ nrdZ nrdE nrdE nrdF2 nrdF2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Rv2491Rv2491, (MTV008.47), len: 207 aa. Conserved hypothetical protein, similar in part to other hypothetical proteins e.g. O29139|AF1126 from Archaeoglobus fulgidus (151 aa), FASTA scores: opt: 293, E(): 2.8e-11, (42.85% identity in 126 aa overlap); O66531|AQ_134 from Aquifex aeolicus (151 aa), FASTA scores: opt: 261, E(): 2.6e-09,(37.75% identity in 106 aa overlap); Q9HKU3|TA0501 from Thermoplasma acidophilum (161 aa), FASTA scores: opt: 260,E(): 3.2e-09, (35.9% identity in 117 aa overlap); etc. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007). (207 aa)    
Predicted Functional Partners:
Rv2492
Hypothetical protein; Rv2492, (MTV008.48), len: 250 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.,2007).
  
    0.967
purF
Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
  
  
 0.820
log
Conserved hypothetical protein; Catalyzes the hydrolytic removal of ribose 5'-monophosphate from nitrogen N6-modified adenosines, the final step of bioactive cytokinin synthesis. Is involved in the synthesis of isopentenyladenine (iP) and 2-methylthio-iP (2MeS-iP), the most abundant cytokinins detected in M.tuberculosis lysates and supernatants. Is also able to convert trans-zeatin-riboside monophosphate (tZRMP) to trans-zeatin (tZ) in vitro; however, it may not be involved in the biosynthesis of this minor cytokinin in vivo. Accumulation of Rv1205 sensitizes M.tuberculosis to nitric o [...]
   
  
 0.809
pyrH
Probable uridylate kinase PyrH (UK) (uridine monophosphate kinase) (UMP kinase); Catalyzes the reversible phosphorylation of UMP to UDP.
     
 0.656
Rv2017
Transcriptional regulatory protein; Rv2017, (MTV018.04), len: 346 aa. Transcriptional regulator. Contains PS00142 Neutral zinc metallopeptidases,zinc-binding region signature in C-terminal half, may be fortuitous. Contains probable helix-turn-helix motif at aa 18-39 (Score 2243, +6.83 SD); IPR001387 Helix-turn-helix type 3.
   
  
 0.631
vapB38
Possible antitoxin VapB38; Probable antitoxin component of a type II toxin-antitoxin (TA) system. Its putative cognate toxin is VapC38.
       0.619
vapC38
Possible toxin VapC38. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase. Its cognate antitoxin is VapB38 (By similarity).
       0.619
nrdZ
Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase); Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).
  
    0.430
nrdE
Ribonucleoside-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. When coexpressed in E.coli with nrdF2 the 2 proteins complement a temperature-sensitive E.coli mutant, however coexpression with nrdF1 does not complement. Belongs to the ribonucleoside diphosphate reductase large chain family.
  
    0.426
nrdF2
Ribonucleoside-diphosphate reductase subunit beta nrdF2; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Two genes for this protein are present in M.tuberculosis; this is the active form. When coexpressed in E.coli with nrdE the 2 proteins complement a temperature-sensitive E.coli mutant; Belongs to the ribonucleoside diphosphate reductase small chain family.
  
    0.418
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.