STRINGSTRING
Rv2666 Rv2666 Rv3023c Rv3023c Rv2512c Rv2512c Rv3115 Rv3115 Rv1047 Rv1047 Rv1199c Rv1199c clpC2 clpC2 Rv2665 Rv2665 Rv2668 Rv2668 Rv2669 Rv2669
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Rv2666Probable transposase for insertion sequence element IS1081 (fragment); Required for the transposition of the insertion element. (267 aa)    
Predicted Functional Partners:
Rv3023c
Probable transposase; Rv3023c, (MTV012.38c), len: 415 aa. Probable IS1081 transposase. Contains PS01007 Transposases, Mutator family,signature. Similars to P35882|TRA1_MYCTU|Rv1199c|MTCI364.11c and Rv2512c|MTCY07A7.18c transposases for insertion sequence element IS1081 (415 aa), FASTA scores: opt: 2675, E(): 1.8e-162, (100.0% identity in 415 aa overlap). Belongs to the mutator family of transposase.
  
   
0.818
Rv2512c
Rv2512c, (MTCY07A7.18c), len: 415 aa. Transposase for IS1081, identical to P35882|TRA1_MYCBO transposase for insertion sequence element IS1081 from Mycobacterium bovis (415 aa), FASTA scores: opt: 2680, E(): 1.9e-162, (100.0% identity in 415 aa overlap). Also highly similar to others from Mycobacterium tuberculosis e.g. P96354|Rv1047|MTCY10G2.02c|Rv3115|MTCY164.25|Rv3023c|MTV01 2.38c (415 aa), FASTA scores: opt: 2675, E(): 3.9e-162, (99.75% identity in 415 aa overlap). Contains PS00435 Peroxidases proximal heme-ligand signature, PS01007 Transposases,Mutator family, signature. Belongs t [...]
  
   
0.803
Rv3115
Probable transposase; Rv3115, (MTCY164.25), len: 415 aa. Probable IS1081 transposase, similar to others. Has transposases, mutator family, signature (PS01007). Other copies are MTCY10G2.02c,MTCY441.35, MTCY77.03c. This region is a possible MT-complex-specific genomic island (See Becq et al.,2007).
  
   
0.803
Rv1047
Probable transposase; Required for the transposition of the insertion element.
  
   
0.797
Rv1199c
Possible transposase; Required for the transposition of the insertion element.
  
   
0.775
clpC2
Rv2667, (MTCY441.36), len: 252 aa. Possible clpC2,ATP-dependent protease atp-binding subunit, highly similar to Q9X8L2|SCE9.40 hypothetical 27.3 KDA protein from Streptomyces coelicolor (258 aa), FASTA scores: opt: 877,E(): 2.2e-46, (57.25% identity in 255 aa overlap). The second half of the protein is highly similar to N-terminal of several CLP-family proteins e.g. P24428|CLPC_MYCLE|ML0235 probable ATP-dependent CLP protease ATP-binding subunit from Mycobacterium leprae (848 aa), FASTA scores: opt: 307, E(): 3.2e-11, (38.6% identity in 158 aa overlap); O06286|CLPC_MYCTU|Rv3596c|MT3703 [...]
       0.715
Rv2665
Rv2665, (MTCY441.34), len: 93 aa. Hypothetical arg-rich protein, showing some similarity to N-terminus of P71640|Rv2811|MTCY16B7.32c hypothetical 21.1 KDA protein from Mycobacterium tuberculosis (202 aa), FASTA scores: opt: 157, E(): 0.0011, (37.5% identity in 72 aa overlap); and also to part of O35132|CP2B_RAT|CYP27B1|CYP27B 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial precursor from Rattus norvegicus (Rat) (501 aa), FASTA scores: opt: 106, E(): 5.4, (34.5% identity in 87 aa overlap).
       0.546
Rv2668
Possible exported alanine and valine rich protein; Rv2668, (MTCY441.37), len: 173 aa. Hypothetical ala-, val-rich protein, possibly exported. Equivalent to AAK47057 from Mycobacterium tuberculosis strain CDC1551 (208 aa) but N-terminal part shorter 35 aa and with few differences. Has potential signal peptide sequence. Predicted to be an outer membrane protein (See Song et al.,2008).
       0.518
Rv2669
GCN5-related N-acetyltransferase; Rv2669, (MTCY441.38), len: 156 aa. Probable acetyltransferase. Contains GNAT (Gcn5-related N-acetyltransferase) domain. See Vetting et al. 2005. Similarity to several proteins e.g. Q9A6M0|CC2073 acetyltransferase (GNAT family) from Caulobacter crescentus (178 aa), FASTA scores: opt: 242, E(): 1.2e-09, (30.9% identity in 165 aa overlap); Q99RQ8|SA2159 hypothetical protein similar to transcription repressor of sporulation,septation and degradation paiA from Staphylococcus aureus subsp. aureus N315 (171 aa), FASTA scores: opt: 214, E(): 9.8e-08, (27.5% id [...]
       0.458
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.