node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rv2696c | Rv2698 | Rv2696c | Rv2698 | Conserved alanine and glycine and valine rich protein; Rv2696c, (MTCY05A6.17c), len: 259 aa. Conserved ala-, gly-, val-rich protein, equivalent (but shorter 18 aa) to Q49993|ML1029|U1764K hypothetical protein from Mycobacterium leprae (273 aa), FASTA scores: opt: 1174,E(): 2.1e-63, (70.6% identity in 262 aa overlap). Also similar to O54135|SC2E9.10 from Streptomyces coelicolor (250 aa), FASTA scores: opt: 213, E(): 9.8e-06, (28.25% identity in 255 aa overlap); and showing weak similarity with other proteins. | Rv2698, (MTCY05A6.19), len: 161 aa. Probable conserved ala-rich transmembrane protein, equivalent to Q49991|ML1027|U1764I possible membrane protein from Mycobacterium leprae (157 aa), FASTA scores: opt: 886, E(): 1.1e-49, (78.9% identity in 161 aa overlap). Also similar to O54132|SC2E9.07c hypothetical 16.5 KDA protein from Streptomyces coelicolor (154 aa), FASTA scores: opt: 230,E(): 7.1e-08, (35.7% identity in 154 aa overlap). | 0.800 |
Rv2696c | dut | Rv2696c | Rv2697c | Conserved alanine and glycine and valine rich protein; Rv2696c, (MTCY05A6.17c), len: 259 aa. Conserved ala-, gly-, val-rich protein, equivalent (but shorter 18 aa) to Q49993|ML1029|U1764K hypothetical protein from Mycobacterium leprae (273 aa), FASTA scores: opt: 1174,E(): 2.1e-63, (70.6% identity in 262 aa overlap). Also similar to O54135|SC2E9.10 from Streptomyces coelicolor (250 aa), FASTA scores: opt: 213, E(): 9.8e-06, (28.25% identity in 255 aa overlap); and showing weak similarity with other proteins. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.793 |
Rv2698 | Rv2696c | Rv2698 | Rv2696c | Rv2698, (MTCY05A6.19), len: 161 aa. Probable conserved ala-rich transmembrane protein, equivalent to Q49991|ML1027|U1764I possible membrane protein from Mycobacterium leprae (157 aa), FASTA scores: opt: 886, E(): 1.1e-49, (78.9% identity in 161 aa overlap). Also similar to O54132|SC2E9.07c hypothetical 16.5 KDA protein from Streptomyces coelicolor (154 aa), FASTA scores: opt: 230,E(): 7.1e-08, (35.7% identity in 154 aa overlap). | Conserved alanine and glycine and valine rich protein; Rv2696c, (MTCY05A6.17c), len: 259 aa. Conserved ala-, gly-, val-rich protein, equivalent (but shorter 18 aa) to Q49993|ML1029|U1764K hypothetical protein from Mycobacterium leprae (273 aa), FASTA scores: opt: 1174,E(): 2.1e-63, (70.6% identity in 262 aa overlap). Also similar to O54135|SC2E9.10 from Streptomyces coelicolor (250 aa), FASTA scores: opt: 213, E(): 9.8e-06, (28.25% identity in 255 aa overlap); and showing weak similarity with other proteins. | 0.800 |
Rv2698 | dut | Rv2698 | Rv2697c | Rv2698, (MTCY05A6.19), len: 161 aa. Probable conserved ala-rich transmembrane protein, equivalent to Q49991|ML1027|U1764I possible membrane protein from Mycobacterium leprae (157 aa), FASTA scores: opt: 886, E(): 1.1e-49, (78.9% identity in 161 aa overlap). Also similar to O54132|SC2E9.07c hypothetical 16.5 KDA protein from Streptomyces coelicolor (154 aa), FASTA scores: opt: 230,E(): 7.1e-08, (35.7% identity in 154 aa overlap). | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.793 |
dcd | dut | Rv0321 | Rv2697c | Probable deoxycytidine triphosphate deaminase Dcd (dCTP deaminase); Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. It also acts as a dUTP diphosphatase. Affinity for dCTP and dUTP are very similar. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.930 |
dcd | ndkA | Rv0321 | Rv2445c | Probable deoxycytidine triphosphate deaminase Dcd (dCTP deaminase); Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. It also acts as a dUTP diphosphatase. Affinity for dCTP and dUTP are very similar. | Probable nucleoside diphosphate kinase NdkA (NDK) (NDP kinase) (nucleoside-2-P kinase); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.926 |
dcd | thyA | Rv0321 | Rv2764c | Probable deoxycytidine triphosphate deaminase Dcd (dCTP deaminase); Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. It also acts as a dUTP diphosphatase. Affinity for dCTP and dUTP are very similar. | Probable thymidylate synthase ThyA (ts) (TSASE); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily. | 0.486 |
dcd | thyX | Rv0321 | Rv2754c | Probable deoxycytidine triphosphate deaminase Dcd (dCTP deaminase); Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. It also acts as a dUTP diphosphatase. Affinity for dCTP and dUTP are very similar. | Probable thymidylate synthase ThyX (ts) (TSase); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. Is essential for growth of the pathogen on solid media in vitro; the essential function is something other than dTMP synthase. | 0.517 |
dcd | tmk | Rv0321 | Rv3247c | Probable deoxycytidine triphosphate deaminase Dcd (dCTP deaminase); Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. It also acts as a dUTP diphosphatase. Affinity for dCTP and dUTP are very similar. | Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK); Catalyzes the reversible phosphorylation of deoxythymidine monophosphate (dTMP) to deoxythymidine diphosphate (dTDP), using ATP as its preferred phosphoryl donor. Situated at the junction of both de novo and salvage pathways of deoxythymidine triphosphate (dTTP) synthesis, is essential for DNA synthesis and cellular growth. Has a broad specificity for nucleoside triphosphates, being highly active with ATP or dATP as phosphate donors, and less active with ITP, GTP, CTP and UTP; Belongs to the thymidylate kinase family. | 0.477 |
dnaN | dut | Rv0002 | Rv2697c | DNA polymerase III (beta chain) DnaN (DNA nucleotidyltransferase); Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta ch [...] | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.743 |
dnaN | lprE | Rv0002 | Rv1252c | DNA polymerase III (beta chain) DnaN (DNA nucleotidyltransferase); Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta ch [...] | Probable lipoprotein LprE; Rv1252c, (MTCY50.30), len: 202 aa. Probable lipoprotein lprE, some similarity to Mycobacterium tuberculosis protein Rv3483c|MTCY13E12.36C (220 aa), FASTA scores: E(): 7e-05, (29.5% identity in 200 aa overlap). Contains possible N-terminal signal sequence and appropriately positioned prokaryotic lipoprotein lipid attachment site (PS00013). A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al.,2004). | 0.590 |
dnaN | recA | Rv0002 | Rv2737c | DNA polymerase III (beta chain) DnaN (DNA nucleotidyltransferase); Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta ch [...] | RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage. | 0.935 |
dnaN | thyA | Rv0002 | Rv2764c | DNA polymerase III (beta chain) DnaN (DNA nucleotidyltransferase); Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta ch [...] | Probable thymidylate synthase ThyA (ts) (TSASE); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily. | 0.713 |
dut | Rv2696c | Rv2697c | Rv2696c | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Conserved alanine and glycine and valine rich protein; Rv2696c, (MTCY05A6.17c), len: 259 aa. Conserved ala-, gly-, val-rich protein, equivalent (but shorter 18 aa) to Q49993|ML1029|U1764K hypothetical protein from Mycobacterium leprae (273 aa), FASTA scores: opt: 1174,E(): 2.1e-63, (70.6% identity in 262 aa overlap). Also similar to O54135|SC2E9.10 from Streptomyces coelicolor (250 aa), FASTA scores: opt: 213, E(): 9.8e-06, (28.25% identity in 255 aa overlap); and showing weak similarity with other proteins. | 0.793 |
dut | Rv2698 | Rv2697c | Rv2698 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Rv2698, (MTCY05A6.19), len: 161 aa. Probable conserved ala-rich transmembrane protein, equivalent to Q49991|ML1027|U1764I possible membrane protein from Mycobacterium leprae (157 aa), FASTA scores: opt: 886, E(): 1.1e-49, (78.9% identity in 161 aa overlap). Also similar to O54132|SC2E9.07c hypothetical 16.5 KDA protein from Streptomyces coelicolor (154 aa), FASTA scores: opt: 230,E(): 7.1e-08, (35.7% identity in 154 aa overlap). | 0.793 |
dut | dcd | Rv2697c | Rv0321 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Probable deoxycytidine triphosphate deaminase Dcd (dCTP deaminase); Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. It also acts as a dUTP diphosphatase. Affinity for dCTP and dUTP are very similar. | 0.930 |
dut | dnaN | Rv2697c | Rv0002 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | DNA polymerase III (beta chain) DnaN (DNA nucleotidyltransferase); Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta ch [...] | 0.743 |
dut | lprE | Rv2697c | Rv1252c | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Probable lipoprotein LprE; Rv1252c, (MTCY50.30), len: 202 aa. Probable lipoprotein lprE, some similarity to Mycobacterium tuberculosis protein Rv3483c|MTCY13E12.36C (220 aa), FASTA scores: E(): 7e-05, (29.5% identity in 200 aa overlap). Contains possible N-terminal signal sequence and appropriately positioned prokaryotic lipoprotein lipid attachment site (PS00013). A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al.,2004). | 0.964 |
dut | ndkA | Rv2697c | Rv2445c | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Probable nucleoside diphosphate kinase NdkA (NDK) (NDP kinase) (nucleoside-2-P kinase); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.956 |
dut | recA | Rv2697c | Rv2737c | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage. | 0.792 |