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Rv2779c Rv2779c Rv3777 Rv3777 Rv0880 Rv0880 ald ald Rv3549c Rv3549c Rv2778c Rv2778c vapC30 vapC30 Rv2272 Rv2272 raaS raaS mce2C mce2C Rv2273 Rv2273
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
Rv2779cPossible transcriptional regulatory protein (probably Lrp/AsnC-family); Rv2779c, (MTV002.44c), len: 179 aa. Possible transcriptional regulator, from the Lrp/AsnC family,similar (but longer ~30 aa in N-terminus) to others e.g. CAC42842|SCBAC36F5.06 putative AsnC-family transcriptional regulatory protein from Streptomyces coelicolor (163 aa),FASTA scores: opt: 333, E(): 4.4e-16, (39.7% identity in 141 aa overlap); O07920|AZLB_BACSU transcriptional regulator (AsnC family) from Bacillus subtilis; Q9I233|PA2082 probable transcriptional regulator (AsnC family) from Pseudomonas aeruginosa (15 [...] (179 aa)    
Predicted Functional Partners:
Rv3777
Rv3777, (MTCY13D12.11), len: 328 aa. Probable oxidoreductase, equivalent to Q9CD96|ML0118 putative oxidoreductase from Mycobacterium leprae (336 aa) FASTA scores: opt: 1661, E(): 1.1e-87, (76.0% identity in 325 aa overlap). Also highly similar to many e.g. Q9XA55|SCGD3.24c putative quinone oxidoreductase from Streptomyces coelicolor (326 aa) FASTA scores: opt: 1118, E(): 1.3e-64,(59.6% identity in 312 aa overlap); O65423|F18E5.200|F17L22.40|AT4G21580 putative NADPH quinone oxidoreductase from Arabidopsis thaliana (Mouse-ear cress) (325 aa), FASTA scores: opt: 1110, E(): 3e-56, (52.15% [...]
   
  
 0.872
Rv0880
Possible transcriptional regulatory protein (possibly MarR-family); Rv0880, (MTCY31.08), len: 143 aa. Possible transcriptional regulator, MarR family, equivalent to MLCB57_15|O3306|NP_302411.1|NC_002677 putative MarR-family protein from Mycobacterium leprae (143 aa), FASTA scores: opt: 818, E(): 0, (89.5% identity in 143 aa overlap). Also similar to many others e.g. CAB93410.1|AL357524 putative marR-family protein from Streptomyces coelicolor (145 aa); NP_251757.1|NC_002516 probable transcriptional regulator from Pseudomonas aeruginosa (147 aa); etc. Also similar to Rv2327 from Mycobac [...]
   
  
 0.858
ald
Secreted L-alanine dehydrogenase Ald (40 kDa antigen) (TB43); Catalyzes the reversible reductive amination of pyruvate to L-alanine. However, since the physiological environment of M.tuberculosis has a neutral pH, it can be assumed that the enzyme catalyzes exclusively the formation of L-alanine. May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer; Belongs to the AlaDH/PNT family.
  
  
 0.837
Rv3549c
Rv3549c, (MTCY03C7.07), len: 259 aa. Probable short-chain dehydrogenase/reductase, similar to various dehydrogenases/reductases (generally belong to the SDR family) e.g. Q9UKU3 from Homo sapiens (Human) (270 aa),FASTA scores: opt: 451, E(): 4.8e-21, (38.05% identity in 247 aa overlap); Q9S274|SCI28.09c from Streptomyces coelicolor (234 aa), FASTA scores: opt: 439, E(): 2.4e-20,(36.8% identity in 231 aa overlap); Q9PFI6|XF0671 from Xylella fastidiosa (247 aa), FASTA scores: opt: 437, E(): 3.4e-20, (37.7% identity in 252 aa overlap); etc. Also highly similar to O33308|FABG5|Rv2766c|MTV00 [...]
   
  
 0.806
Rv2778c
Conserved protein; Rv2778c, (MTV002.43c), len: 156 aa. Conserved protein, similar to Q9CBF7|ML2031 hypothetical protein from Mycobacterium leprae (151 aa), FASTA scores: opt: 227, E(): 8.5e-09, (35.95% identity in 153 aa overlap). Also similar to AAK46204|MT1931.1 hypothetical 17.8 KDA protein from Mycobacterium tuberculosis strain CDC1551 (158 aa), FASTA scores: opt: 238, E(): 1.5e-09, (35.75% identity in 151 aa overlap); or O07748|Rv1883c|MTCY180.35 hypothetical 17.3 KDA protein from Mycobacterium tuberculosis strain H37Rv (158 aa), FASTA scores: opt: 212, E(): 9.7e-08, (34.45% ident [...]
  
    0.774
vapC30
Possible toxin VapC30. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB30.; Belongs to the PINc/VapC protein family.
   
    0.730
Rv2272
Rv2272, (MTCY339.38c), len: 122 aa. Probable conserved transmembrane protein, similar to YIDH_ECOLI P31445 hypothetical 12.8 kDa protein (115 aa), FASTA scores, opt: 291, E(): 2.9e-14, (45.6% identity in 103 aa overlap), similar to MTCY339.37c, (35.0% identity in 100 aa overlap).
  
   
 0.692
raaS
Probable transcriptional regulatory protein; Regulates the expression of the Rv1217c-Rv1218c multidrug efflux system and its own expression. Acts by binding to promoter regions of Rv1219c and upstream of the Rv1218c gene. Important for survival in prolonged stationary phase and during macrophage infection. May be used to eliminate non- growing mycobacteria.
   
  
 0.679
mce2C
Mce-family protein Mce2C; Rv0591, (MTCY19H5.31c), len: 481 aa. Mce2C; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below), highly similar to Mycobacterium tuberculosis proteins O07415|R0171|MTCI28.11|mce1C (515 aa); O53969|Rv1968|MTV051.06|mce3C (410 aa); etc. Also highly similar to others e.g. NP_302658.1|NC_002677 putative secreted protein from Mycobacterium leprae (519 aa); CAC12796.1|AL445327 putative secreted protein from Streptomyces coelicolor (351 aa); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop), and may contain N-terminal [...]
   
  
 0.656
Rv2273
Rv2273, (MTCY339.37c), len: 109 aa. Probable conserved transmembrane protein, similar to Rv2272 (MTCY339.38c), (35.0% identity in 100 aa overlap).
      
 0.652
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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