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fadE21 fadE21 ltp1 ltp1 Rv2791c Rv2791c Rv2792c Rv2792c fixB fixB fixA fixA fadB fadB truB truB pptT pptT Rv2795c Rv2795c fadE32 fadE32
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Cooccurrence
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Experiments
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[Homology]
Score
fadE21Rv2789c, (MTV002.54c), len: 410 aa. Probable fadE21,acyl-CoA dehydrogenase, similar to many e.g. P45857|ACDB_BACSU|MMGC from Bacillus subtilis (379 aa),FASTA scores: opt: 689, E(): 9.3e-37, (35.75% identity in 400 aa overlap); Q9K6D1|ACDA|BH3798 from Bacillus halodurans (380 aa), FASTA scores: opt: 679, E(): 4.1e-36,(37.3% identity in 405 aa overlap); Q06319|ACDS_MEGEL from Megasphaera elsdenii (383 aa), FASTA scores: opt: 650, E(): 3e-34, (37.7% identity in 334 aa overlap); etc. Contains acyl-CoA dehydrogenases signature 1 (PS00072). Belongs to the acyl-CoA dehydrogenases family. (410 aa)    
Predicted Functional Partners:
ltp1
Rv2790c, (MTV002.55c), len: 401 aa. Probable ltp1,lipid-transfer protein, highly similar to many eukaryotic sterol-carrier proteins/lipid-transfer protein precursors (see Ossendorp & Wirtz 1993) e.g. O62742|SCP2 sterol carrier protein X from Oryctolagus cuniculus (Rabbit) (547 aa), FASTA scores: opt: 1710, E(): 6e-102, (63.7% identity in 394 aa overlap); Q9QW19 3-oxoacyl-CoA thiolase homolog (fragment) from Rattus sp. (405 aa), FASTA scores: opt: 1696, E(): 3.8e-101, (63.2% identity in 394 aa overlap); P11915|NLTP_RAT|SCP2|SCP-2 nonspecific lipid-transfer protein precursor from Rattus [...]
  
 
 0.977
Rv2791c
Probable transposase; Rv2791c, (MTV002.56c), len: 459 aa. Probable IS1602 transposase for IS1602 element, similar to many e.g. P95117|Rv2978c|MTCY349.09 from Mycobacterium tuberculosis (459 aa), FASTA scores: opt: 2718, E(): 6.3e-165, (86.05% identity in 459 aa overlap).
  
    0.949
Rv2792c
Possible resolvase; Rv2792c, (MTV002.57c), len: 193 aa. Possible IS1602 resolvase, highly similar to many from Mycobacterium tuberculosis e.g. O07773|Rv0605|MTCY19H5.17c possible resolvase (202 aa), FASTA scores: opt: 1040, E(): 1.9e-62,(85.05% identity in 194 aa overlap). Contains PS00397 Site-specific recombinases active site and possible helix-turn-helix motif at aa 1-2 (Score 1687, +4.93 SD).
  
    0.931
fixB
Electron transfer flavoprotein subunit alpha; The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (By similarity).
 
 0.870
fixA
Electron transfer flavoprotein subunit beta; The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (By similarity).
 
 
 0.851
fadB
Rv0860, (MTV043.53), len: 720 aa. Probable fadB,fatty oxidation protein, equivalent to NP_302422.1|NC_002677 putative fatty oxidation complex alpha subunit from Mycobacterium leprae (714 aa). Also highly similar to others and various proteins involved in fatty acid metabolism, e.g. T35429 probable fatty oxidation protein from Streptomyces coelicolor (733 aa); NP_250428.1|NC_002516 probable 3-hydroxyacyl-CoA dehydrogenase from Pseudomonas aeruginosa (714 aa); NP_418895.1|NC_002696 fatty oxidation complex alpha subunit from Caulobacter crescentus (709 aa); P40939|ECHA_HUMAN trifunctional [...]
  
 0.802
truB
tRNA pseudouridine synthase B; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
  
   0.716
pptT
Rv2794c, (MTV002.59c), len: 227 aa. PptT,phosphopantetheinyl transferase, equivalent to Q9Z5I5|ML1547|MLCB596.23 putative iron-chelating complex subunit from Mycobacterium leprae (227 aa), FASTA scores: opt: 1248, E(): 9.1e-77, (79.75% identity in 227 aa overlap). Also highly similar to various proteins e.g. Q9F0Q6|PPTA phosphopantetheinyl transferase from Streptomyces verticillus (246 aa), FASTA scores: opt: 692,E(): 2.8e-39, (46.65% identity in 225 aa overlap); O88029|SC5A7.23 hypothetical 24.5 KDA protein from Streptomyces coelicolor (226 aa), FASTA scores: opt: 679,E(): 2e-38, (46. [...]
  
    0.710
Rv2795c
Rv2795c, (MTV002.60c), len: 324 aa. Conserved hypothetical protein, equivalent to Q9Z5I6|ML1548|MLCB596.22 hypothetical 37.5 KDA protein from Mycobacterium leprae (321 aa), FASTA scores: opt: 2018,E(): 6.3e-128, (87.4% identity in 318 aa overlap). Also highly similar to O88028|SC5A7.22 hypothetical 33.5 KDA protein from Streptomyces coelicolor (295 aa), FASTA scores: opt: 1202, E(): 3.4e-73, (57.2% identity in 285 aa overlap); and Q9AMH7|SIMX4 SIMX4 protein from Streptomyces antibioticus (293 aa), FASTA scores: opt: 1045, E(): 1.2e-62, (51.4% identity in 286 aa overlap). C-terminus hig [...]
  
    0.704
fadE32
Rv3563, (MTCY06G11.10), len: 319 aa. Probable fadE32, acyl-CoA dehydrogenase, similar to many e.g. Q9I4V4|PA1020 from Pseudomonas aeruginosa (370 aa), FASTA scores: opt: 347, E(): 7.6e-14, (35.15% identity in 333 aa overlap); Q9RJX3|SCF37.28c from Streptomyces coelicolor (362 aa), FASTA scores: opt: 300, E(): 5.3e-11, (32.4% identity in 349 aa overlap); Q9A5G8|CC2479 from Caulobacter crescentus (344 aa), FASTA scores: opt: 285, E(): 4.1e-10,(30.4% identity in 329 aa overlap); P45857|ACDB_BACSU|MMGC from Bacillus subtilis (379 aa), FASTA scores: opt: 230,E(): 1.1e-07, (25.5% identity in [...]
  
    0.669
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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