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Rv2792c Rv2792c Rv2791c Rv2791c Rv2978c Rv2978c Rv0606 Rv0606 fadE21 fadE21 Rv3827c Rv3827c Rv2885c Rv2885c Rv0185 Rv0185 Rv0922 Rv0922 ltp1 ltp1 Rv0605 Rv0605
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
Rv2792cPossible resolvase; Rv2792c, (MTV002.57c), len: 193 aa. Possible IS1602 resolvase, highly similar to many from Mycobacterium tuberculosis e.g. O07773|Rv0605|MTCY19H5.17c possible resolvase (202 aa), FASTA scores: opt: 1040, E(): 1.9e-62,(85.05% identity in 194 aa overlap). Contains PS00397 Site-specific recombinases active site and possible helix-turn-helix motif at aa 1-2 (Score 1687, +4.93 SD). (193 aa)    
Predicted Functional Partners:
Rv2791c
Probable transposase; Rv2791c, (MTV002.56c), len: 459 aa. Probable IS1602 transposase for IS1602 element, similar to many e.g. P95117|Rv2978c|MTCY349.09 from Mycobacterium tuberculosis (459 aa), FASTA scores: opt: 2718, E(): 6.3e-165, (86.05% identity in 459 aa overlap).
 
  
 0.995
Rv2978c
Probable transposase; Rv2978c, (MTCY349.09), len: 459 aa. Probable transposase for IS1538, very similar to several other putative transposases from Mycobacterium tuberculosis e.g. YX16_MYCTU|Q10809 (460 aa), FASTA scores: opt: 2613, E(): 0, (83.0% identity in 458 aa overlap); etc. Low level matches to other tranposases.
 
  
 0.940
Rv0606
Possible transposase (fragment); Rv0606, (MTCY19H5.16c), len: 247 aa. Possible truncated transposase for IS_1536 element, highly similar to N-terminus of other transposases from Mycobacterium tuberculosis e.g. YX16_MYCTU|Q10809|Rv2885c|MT2953|MTCY274.16c putative transposase from Mycobacterium tuberculosis (460 aa), FASTA scores: opt: 1368, E(): 0, (83.5% identity in 237 aa overlap); Rv2978c, Rv0922, Rv3827c, etc. Also similar to N-terminus of MTV002_57|Rv2792 resolvase from M. tuberculosis (193 aa), FASTA score: (87.4% identity in 238 aa overlap). This region is a possible MT-complex- [...]
 
  
 0.935
fadE21
Rv2789c, (MTV002.54c), len: 410 aa. Probable fadE21,acyl-CoA dehydrogenase, similar to many e.g. P45857|ACDB_BACSU|MMGC from Bacillus subtilis (379 aa),FASTA scores: opt: 689, E(): 9.3e-37, (35.75% identity in 400 aa overlap); Q9K6D1|ACDA|BH3798 from Bacillus halodurans (380 aa), FASTA scores: opt: 679, E(): 4.1e-36,(37.3% identity in 405 aa overlap); Q06319|ACDS_MEGEL from Megasphaera elsdenii (383 aa), FASTA scores: opt: 650, E(): 3e-34, (37.7% identity in 334 aa overlap); etc. Contains acyl-CoA dehydrogenases signature 1 (PS00072). Belongs to the acyl-CoA dehydrogenases family.
  
    0.931
Rv3827c
Possible transposase; Rv3827c, (MTCY409.03), len: 408 aa. Possible transposase within IS1537 element, similar to several transposases e.g. O83029|TNPC|DR2324|DR0666|DR0978|DR1381|DR1651|DR1933 transposase from Deinococcus radiodurans(408 aa) FASTA scores: opt: 302, E(): 3.9e-12, (30.75% identity in 358 aa overlap); Q9RXX7|DR0178 putative transposase from Deinococcus radiodurans (409 aa), FASTA scores: opt: 297,E(): 8.2e-12, (31.1% identity in 360 aa overlap); P73816|SLR2062 transposase from Synechocystis sp. strain PCC 6803 (400 aa), FASTA scores: opt: 296, E(): 9.3e-12,(30.05% identit [...]
 
  
 0.866
Rv2885c
Probable transposase; Rv2885c, (MTCY274.16c), len: 460 aa. Probable transposase for IS1539. Contains PS00017 ATP/GTP-binding site motif A (P-loop); In the N-terminal section; belongs to the transposase 2 family.
 
  
 0.850
Rv0185
Rv0185, (MTCI28.25a), len: 169 aa. Conserved hypothetical protein, equivalent to CAB08794.1|Z95398|MLCL622_2 from Mycobacterium leprae (168 aa), FASTA scores: opt: 861, E(): 0, (76.4% identity in 165 aa overlap). Contains PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004).
   
    0.797
Rv0922
Possible transposase; Rv0922, (MTCY21C12.16), len: 550 aa. Possible transposase for IS1535, similar to many e.g. YX16_MYCTU|Q10809|MTCY274.16c from Mycobacterium tuberculosis (460 aa), FASTA scores: opt 939, E(): 0,(40.6% identity in 465 aa overlap); etc.
 
  
 0.795
ltp1
Rv2790c, (MTV002.55c), len: 401 aa. Probable ltp1,lipid-transfer protein, highly similar to many eukaryotic sterol-carrier proteins/lipid-transfer protein precursors (see Ossendorp & Wirtz 1993) e.g. O62742|SCP2 sterol carrier protein X from Oryctolagus cuniculus (Rabbit) (547 aa), FASTA scores: opt: 1710, E(): 6e-102, (63.7% identity in 394 aa overlap); Q9QW19 3-oxoacyl-CoA thiolase homolog (fragment) from Rattus sp. (405 aa), FASTA scores: opt: 1696, E(): 3.8e-101, (63.2% identity in 394 aa overlap); P11915|NLTP_RAT|SCP2|SCP-2 nonspecific lipid-transfer protein precursor from Rattus [...]
  
    0.794
Rv0605
Possible resolvase; Rv0605, (MTCY19H5.17c), len: 202 aa. Possible resolvase for IS_Y349 element, similar to several Mycobacterial hypothetical proteins and weakly similar to Q52563 resolvase from Pseudomonas syringae (210 aa), FASTA scores: opt: 99, E(): 3.1, (35.7% identity in 98 aa overlap). Contains PS00397 Site-specific recombinases active site and probable helix-turn helix motif from aa 9-30 (Score 1815, +5.37 SD). This region is a possible MT-complex-specific genomic island (See Becq et al.,2007).
  
   
0.759
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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