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Rv2943A Rv2943A Rv2944 Rv2944 Rv2943 Rv2943 dnaB dnaB Rv3637 Rv3637 Rv3427c Rv3427c Rv3428c Rv3428c Rv3636 Rv3636
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
Rv2943ARv2943A, len: 176 aa. Possible transposase, similar to many e.g. AJ238712|MBO238712_2 putative transposase (IS21-l) from Mycobacterium bovis BCG (266 aa), FASTA scores: opt: 762, E(): 0, (100.0% identity in 118 aa overlap). Possible frameshift after codon 118 i.e. near position 3290056, to fuse with Rv2944. (176 aa)    
Predicted Functional Partners:
Rv2944
Rv2944, (MTCY24G1.05c), len: 238 aa. Possible transposase for IS1533, similar to is-element proteins e.g. P15026|ISTB_ECOLI istb protein from Escherichia coli (265 aa), FASTA scores: opt: 475, E (): 1.6e-21, (48.0% identity in 148 aa overlap); Z95436|MTY15C10_14 from Mycobacterium tuberculosis (248 aa), FASTA scores: opt: 784, E(): 0,(87.4% identity in 135 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop).
 
    0.982
Rv2943
Rv2943, (MTCY24G1.06c), len: 413 aa. Probable transposase for insertion sequence IS1533, similar to other transposases e.g. P15025|ISTA_ECOLI ista protein (insertion sequence IS21) from Escherichia coli (390 aa), FASTA scores: opt: 268, E(): 5.1e-11, (24.1% identity in 378 aa overlap). Contains potential helix-turn-helix motif at aa 19-40 (Score 1611, +4.67 SD).
 
  
 0.958
dnaB
Probable replicative DNA helicase DnaB; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity; Belongs to the helicase family. DnaB subfamily.
  
 
 0.816
Rv3637
Possible transposase; Rv3637, (MTCY15C10.15c), len: 166 aa. Possible transposase. C-terminal end highly similar to Q9RLQ9|ISTA putative transposase a (fragment) from Mycobacterium bovis (102 aa), FASTA scores: opt: 397, E(): 1.4e-19, (58.8% identity in 102 aa overlap). Weakly similar to others e.g. Q9KJ02 putative transposase (fragment) from Polyangium cellulosum (329 aa), FASTA scores: opt: 191, E(): 1.6e-05,(32.1% identity in 134 aa overlap); Q9LCU2|ISTA cointegrase from Pseudomonas aeruginosa (382 aa) FASTA scores: opt: 144, E(): 0.024, (26.8% identity in 123 aa overlap); P15025|IST [...]
 
  
 0.788
Rv3427c
Possible transposase; Rv3427c, (MTCY78.02), len: 251 aa. Possible transposase, similar to other e.g. Q9APG8|ORF2 putative transposase subunit 2 from Pseudomonas putida (251 aa),FASTA scores: opt: 479, E(): 1.8e-21, (34.85% identity in 238 aa overlap). Contains PS00017 ATP/GTP-binding site motif A.
  
    0.773
Rv3428c
Possible transposase; Rv3428c, (MTCY78.01, len: 410 aa. Possible transposase insertion sequence, similar to others e.g. Q9APG9|ORF1 from Pseudomonas putida (509 aa), FASTA scores: opt: 578, E(): 1.1e-29, (32.45% identity in 376 aa overlap); P55379|Y4BL_RHISN from Rhizobium sp. strain NGR234 (516 aa), FASTA scores: opt: 665, E(): 2.7e-35,(35.3% identity in 391 aa overlap); etc.
 
  
 0.773
Rv3636
Possible transposase; Rv3636, (MTCY15C10.16c), len: 115 aa. Possible transposase, weakly similar to others e.g. O69924|SC3C8.12 putative transposase from Streptomyces coelicolor (487 aa) FASTA scores: opt: 132, E(): 0.12, (33.05% identity in 112 aa overlap); O96916 TC1-like transposase from Anopheles gambiae (African malaria mosquito) (332 aa), FASTA scores: opt: 117, E(): 0.84, (30.75% identity in 91 aa overlap); Q9R2U5|IS466A|IS466A-ORF|TNPA|IS469|SCP1.276 transposase (insertion element IS466S transposase) from Streptomyces coelicolor (513 aa), FASTA scores: opt: 114, E(): 2, (30.5% [...]
 
  
 0.717
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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