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Rv2959c Rv2959c Rv2958c Rv2958c Rv2949c Rv2949c epiA epiA Rv2960c Rv2960c PE_PGRS28 PE_PGRS28 Rv3295 Rv3295 Rv2075c Rv2075c vapC16 vapC16 PPE8 PPE8 Rv2962c Rv2962c
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
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gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Rv2959cPossible methyltransferase (methylase); Catalyzes the O-methylation of the hydroxyl group located on C-2 of the first rhamnosyl residue linked to the phenolic group of glycosylated phenolphthiocerol dimycocerosates (PGL) and p- hydroxybenzoic acid derivatives (p-HBAD). (245 aa)    
Predicted Functional Partners:
Rv2958c
Possible glycosyl transferase; Involved in glycosylation steps downstream of mono-O-methyl- glycosyl-p-hydroxybenzoic acid derivative (p-HBAD I) and 2-O-methyl- rhamnosyl-phenolphthiocerol dimycocerosate (mycoside B) during the p- hydroxybenzoic acid derivatives (p-HBAD) and glycosylated phenolphthiocerol dimycocerosates (PGL) biosynthesis.
  
 
 0.979
Rv2949c
Chorismate pyruvate lyase; Removes the pyruvyl group from chorismate to provide 4- hydroxybenzoate (4HB). Involved in the synthesis of glycosylated p- hydroxybenzoic acid methyl esters (p-HBADs) and phenolic glycolipids (PGL) that play important roles in the pathogenesis of mycobacterial infections.
  
  
 0.905
epiA
Probable nucleotide-sugar epimerase EpiA; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.
  
  
 0.760
Rv2960c
Hypothetical protein; Rv2960c, (MT3036, MTCY349.28), len: 82 aa. Hypothetical unknown protein, equivalent to AAK47362 from Mycobacterium tuberculosis strain CDC1551 (116 aa) but shorter 34 aa. Shortened version of MTCY349.28 avoiding overlap. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007).
  
  
 0.647
PE_PGRS28
PE-PGRS family protein PE_PGRS28; Rv1452c, (MTCY493.02), len: 741 aa. PE_PGRS28,Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see Brennan and Delogu,2002), similar to Y03A_MYCTU|Q10637 hypothetical glycine-rich 49.6 kDa protein (603 aa), fasta scores: opt: 2090, E(): 0, (56.3% identity in 641 aa overlap).
  
     0.633
Rv3295
Probable transcriptional regulatory protein (probably TetR-family); Rv3295, (MTCY71.35), len: 221 aa. Probable transcriptional regulator TetR-family, equivalent to Q9CCL4|ML0717 putative TetR-family transcriptional regulator from Mycobacterium leprae (223 aa), FASTA scores: opt: 1260, E(): 7.2e-75, (85.45% identity in 220 aa overlap). Also highly similar to other streptomyces regulators e.g. Q9RD77|SCF43.11 from Streptomyces coelicolor (205 aa), FASTA scores: opt: 442, E(): 9.8e-22,(38.6% identity in 202 aa overlap); Q9RKY8|SC6D7.09 from Streptomyces coelicolor (220 aa), FASTA scores: [...]
   
  
 0.629
Rv2075c
Rv2075c, (MTCY49.14c), len: 487 aa. Possibly exported or envelope protein; has potential signal peptide at N-terminus and hydrophobic stretch around residue 430. Predicted to be an outer membrane protein (See Song et al.,2008).
  
     0.626
vapC16
Possible toxin VapC16; Toxic component of a type II toxin-antitoxin (TA) system. An RNase. The cognate antitoxin is VapB16 (By similarity). Belongs to the PINc/VapC protein family.
  
     0.602
PPE8
PPE family protein PPE8; Rv0355c, (MTCY13E10.15c, MTCY13E10.16c,MTCY13E10.17c), len: 3300 aa. PPE8, Member of the Mycobacterium tuberculosis PPE family, similar to others e.g. AL009198|MTV004_5 from Mycobacterium tuberculosis (3716 aa), FASTA scores: opt: 2906, E(): 0, (40.9% identity in 3833 aa overlap); MTV004_3 FASTA scores: (39.0% identity in 3531 aa overlap); etc. Gene contains large number of clustered Major Polymorphic Tandem Repeats (MPTR). Related to MTCY13E10.16c, E(): 0; MTCY13E10.17c, E(): 0; MTCY48.17,E(): 0; MTCY98.0034c, E(): 0; MTCY03C7.23 E(): 0; MTCY98.0031c, E(): 0; [...]
  
    0.600
Rv2962c
Possible glycosyl transferase; Catalyzes the transfer of the first rhamnosyl residue on p- hydroxybenzoic acid or phenolphthiocerol derivatives to form, after O- methylation at position 2 of the sugar unit, mono-O-methyl-glycosyl-p- hydroxybenzoic acid derivative (p-HBAD I) and 2-O-methyl-rhamnosyl- phenolphthiocerol dimycocerosate (also called mycoside B) during p- hydroxybenzoic acid derivatives (p-HBAD) and glycosylated phenolphthiocerol dimycocerosates (PGL) biosynthesis. Belongs to the glycosyltransferase 28 family.
  
 
 0.598
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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