node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rv0191 | Rv1667c | Rv0191 | Rv1667c | Probable conserved integral membrane protein; Active efflux pump that plays an important role in chloramphenicol resistance. Overexpression causes pyrazinamide resistance. Belongs to the major facilitator superfamily. | Rv1667c, (MTV047.03c), len: 217 aa. Probable second part of macrolide-transport ATP-binding protein ABC transporter (see citation below), with similarity to C-terminal end of putative ABC transporters/ATP binding proteins, e.g. Z99108|BSUB0005_6 ABC transporter (ATP-binding protein) homolog yfmR from Bacillus subtilis (629 aa), FASTA scores: opt: 411, E(): 6.9e-17, (37.8% identity in 217 aa overlap); etc. Similarity to other NBD components of ABC transporters suggests that Rv1667c and Rv1668c should be contiguous. However, sequence has been checked and no errors found, also same sequen [...] | 0.837 |
Rv0191 | Rv3008 | Rv0191 | Rv3008 | Probable conserved integral membrane protein; Active efflux pump that plays an important role in chloramphenicol resistance. Overexpression causes pyrazinamide resistance. Belongs to the major facilitator superfamily. | Hypothetical protein; Rv3008, (MTV012.22), len: 207 aa (start uncertain). Hypothetical unknown protein. | 0.871 |
Rv0191 | panD | Rv0191 | Rv3601c | Probable conserved integral membrane protein; Active efflux pump that plays an important role in chloramphenicol resistance. Overexpression causes pyrazinamide resistance. Belongs to the major facilitator superfamily. | Probable aspartate 1-decarboxylase precursor PanD (aspartate alpha-decarboxylase); Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine; Belongs to the PanD family. | 0.461 |
Rv0191 | proZ | Rv0191 | Rv3756c | Probable conserved integral membrane protein; Active efflux pump that plays an important role in chloramphenicol resistance. Overexpression causes pyrazinamide resistance. Belongs to the major facilitator superfamily. | Rv3756c, (MTV025.104c), len: 239 aa. Possible proZ,osmoprotectant transport integral membrane protein ABC transporter (see citation below), similar to osmoprotection proteins (proW, proZ) involved in glycine betaine/L-proline/choline transport, e.g. BAB58609|Q99RI4|OPUCB|SA2236|SAV2447 OPUCB protein (probable glycine betaine/carnitine/choline ABC transporter) from Staphylococcus aureus (211 aa) FASTA scores: opt: 434, E(): 2.5e-18, (36.6% identity in 194 aa overlap); Q45461|OPBB_BACSU|OPUBB|prow choline transport system permease protein (mediate the uptake of choline for synthesis of t [...] | 0.661 |
Rv1624c | Rv3008 | Rv1624c | Rv3008 | Rv1624c, (MTCY01B2.16c), len: 195 aa. Probable membrane protein, first start taken. Some similarity to Rv3155 nuoK, NADH dehydrogenase chain K from M. tuberculosis. Also similar to AAK72093.1|AF196488 hypothetical protein from Mycobacterium smegmatis (205 aa). Identities = 117/195 (60%). | Hypothetical protein; Rv3008, (MTV012.22), len: 207 aa (start uncertain). Hypothetical unknown protein. | 0.687 |
Rv1667c | Rv0191 | Rv1667c | Rv0191 | Rv1667c, (MTV047.03c), len: 217 aa. Probable second part of macrolide-transport ATP-binding protein ABC transporter (see citation below), with similarity to C-terminal end of putative ABC transporters/ATP binding proteins, e.g. Z99108|BSUB0005_6 ABC transporter (ATP-binding protein) homolog yfmR from Bacillus subtilis (629 aa), FASTA scores: opt: 411, E(): 6.9e-17, (37.8% identity in 217 aa overlap); etc. Similarity to other NBD components of ABC transporters suggests that Rv1667c and Rv1668c should be contiguous. However, sequence has been checked and no errors found, also same sequen [...] | Probable conserved integral membrane protein; Active efflux pump that plays an important role in chloramphenicol resistance. Overexpression causes pyrazinamide resistance. Belongs to the major facilitator superfamily. | 0.837 |
Rv1667c | Rv3008 | Rv1667c | Rv3008 | Rv1667c, (MTV047.03c), len: 217 aa. Probable second part of macrolide-transport ATP-binding protein ABC transporter (see citation below), with similarity to C-terminal end of putative ABC transporters/ATP binding proteins, e.g. Z99108|BSUB0005_6 ABC transporter (ATP-binding protein) homolog yfmR from Bacillus subtilis (629 aa), FASTA scores: opt: 411, E(): 6.9e-17, (37.8% identity in 217 aa overlap); etc. Similarity to other NBD components of ABC transporters suggests that Rv1667c and Rv1668c should be contiguous. However, sequence has been checked and no errors found, also same sequen [...] | Hypothetical protein; Rv3008, (MTV012.22), len: 207 aa (start uncertain). Hypothetical unknown protein. | 0.872 |
Rv1667c | proZ | Rv1667c | Rv3756c | Rv1667c, (MTV047.03c), len: 217 aa. Probable second part of macrolide-transport ATP-binding protein ABC transporter (see citation below), with similarity to C-terminal end of putative ABC transporters/ATP binding proteins, e.g. Z99108|BSUB0005_6 ABC transporter (ATP-binding protein) homolog yfmR from Bacillus subtilis (629 aa), FASTA scores: opt: 411, E(): 6.9e-17, (37.8% identity in 217 aa overlap); etc. Similarity to other NBD components of ABC transporters suggests that Rv1667c and Rv1668c should be contiguous. However, sequence has been checked and no errors found, also same sequen [...] | Rv3756c, (MTV025.104c), len: 239 aa. Possible proZ,osmoprotectant transport integral membrane protein ABC transporter (see citation below), similar to osmoprotection proteins (proW, proZ) involved in glycine betaine/L-proline/choline transport, e.g. BAB58609|Q99RI4|OPUCB|SA2236|SAV2447 OPUCB protein (probable glycine betaine/carnitine/choline ABC transporter) from Staphylococcus aureus (211 aa) FASTA scores: opt: 434, E(): 2.5e-18, (36.6% identity in 194 aa overlap); Q45461|OPBB_BACSU|OPUBB|prow choline transport system permease protein (mediate the uptake of choline for synthesis of t [...] | 0.659 |
Rv3007c | Rv3008 | Rv3007c | Rv3008 | Rv3007c, (MTV012.21c), len: 204 aa. Possible oxidoreductase, similar to Q9EWU5|3SC5B7.04c putative oxidoreductase from Streptomyces coelicolor (162 aa), FASTA scores: opt: 376, E(): 1.5e-18, (41.35% identity in 150 aa overlap); Q9K416|SCG22.29c putative flavin-dependent reductase protein from Streptomyces coelicolor (169 aa),FASTA scores: opt: 246, E(): 1e-09, (34.1% identity in 135 aa overlap); and some similarity to coupling proteins of 4-hydroxyphenylacetic hydroxylase/monooxygenase e.g. Q9HWT6|HPAC|PA4092 Pseudomonas aeruginosa (170 aa), FASTA score: opt: 214; O68232|HPAC Photorhab [...] | Hypothetical protein; Rv3008, (MTV012.22), len: 207 aa (start uncertain). Hypothetical unknown protein. | 0.532 |
Rv3008 | Rv0191 | Rv3008 | Rv0191 | Hypothetical protein; Rv3008, (MTV012.22), len: 207 aa (start uncertain). Hypothetical unknown protein. | Probable conserved integral membrane protein; Active efflux pump that plays an important role in chloramphenicol resistance. Overexpression causes pyrazinamide resistance. Belongs to the major facilitator superfamily. | 0.871 |
Rv3008 | Rv1624c | Rv3008 | Rv1624c | Hypothetical protein; Rv3008, (MTV012.22), len: 207 aa (start uncertain). Hypothetical unknown protein. | Rv1624c, (MTCY01B2.16c), len: 195 aa. Probable membrane protein, first start taken. Some similarity to Rv3155 nuoK, NADH dehydrogenase chain K from M. tuberculosis. Also similar to AAK72093.1|AF196488 hypothetical protein from Mycobacterium smegmatis (205 aa). Identities = 117/195 (60%). | 0.687 |
Rv3008 | Rv1667c | Rv3008 | Rv1667c | Hypothetical protein; Rv3008, (MTV012.22), len: 207 aa (start uncertain). Hypothetical unknown protein. | Rv1667c, (MTV047.03c), len: 217 aa. Probable second part of macrolide-transport ATP-binding protein ABC transporter (see citation below), with similarity to C-terminal end of putative ABC transporters/ATP binding proteins, e.g. Z99108|BSUB0005_6 ABC transporter (ATP-binding protein) homolog yfmR from Bacillus subtilis (629 aa), FASTA scores: opt: 411, E(): 6.9e-17, (37.8% identity in 217 aa overlap); etc. Similarity to other NBD components of ABC transporters suggests that Rv1667c and Rv1668c should be contiguous. However, sequence has been checked and no errors found, also same sequen [...] | 0.872 |
Rv3008 | Rv3007c | Rv3008 | Rv3007c | Hypothetical protein; Rv3008, (MTV012.22), len: 207 aa (start uncertain). Hypothetical unknown protein. | Rv3007c, (MTV012.21c), len: 204 aa. Possible oxidoreductase, similar to Q9EWU5|3SC5B7.04c putative oxidoreductase from Streptomyces coelicolor (162 aa), FASTA scores: opt: 376, E(): 1.5e-18, (41.35% identity in 150 aa overlap); Q9K416|SCG22.29c putative flavin-dependent reductase protein from Streptomyces coelicolor (169 aa),FASTA scores: opt: 246, E(): 1e-09, (34.1% identity in 135 aa overlap); and some similarity to coupling proteins of 4-hydroxyphenylacetic hydroxylase/monooxygenase e.g. Q9HWT6|HPAC|PA4092 Pseudomonas aeruginosa (170 aa), FASTA score: opt: 214; O68232|HPAC Photorhab [...] | 0.532 |
Rv3008 | ctpE | Rv3008 | Rv0908 | Hypothetical protein; Rv3008, (MTV012.22), len: 207 aa (start uncertain). Hypothetical unknown protein. | Probable metal cation transporter ATPase P-type CtpE; P-type ATPase involved in specific uptake of calcium. | 0.546 |
Rv3008 | ctpF | Rv3008 | Rv1997 | Hypothetical protein; Rv3008, (MTV012.22), len: 207 aa (start uncertain). Hypothetical unknown protein. | Rv1997, (MTCY39.22c, MTCY39.21c), len: 905 aa. Probable ctpF, metal cation-transporting P-type ATPase F (transmembrane protein), highly similar to others e.g. NP_250120.1|NC_002516 probable cation-transporting P-type ATPase from Pseudomonas aeruginosa (902 aa); NP_441217.1|NC_000911 cation-transporting ATPase (E1-E2 ATPase) from Synechocystis sp. strain PCC 6803 (905 aa); NP_404093.1|NC_003143 putative cation-transporting P-type ATPase from Yersinia pestis (908 aa); P37367|ATA1_SYNY3 cation-transporting ATPase pma1 from Synechocystis sp. (915 aa), FASTA scores: opt: 2392, E(): 0, (46.5 [...] | 0.546 |
Rv3008 | ctpH | Rv3008 | Rv0425c | Hypothetical protein; Rv3008, (MTV012.22), len: 207 aa (start uncertain). Hypothetical unknown protein. | Rv0425c, (MTCY22G10.22c), len: 1539 aa. Possible ctpH, metal cation-transporting P-type ATPase (transmembrane protein), showing some similarity with CAA17934.1|AL022118|13093871|CAC32203.1|AL583926 putative cation-transporting ATPase from Mycobacterium leprae (1609 aa). Also similar to others ATPases e.g. AE000873_1 cation-transporting P-ATPase from Methanobacterium thermoautotrop (844 aa), FASTA score: (30.5% identity in 827 aa overlap); AB69720.1|AL137166 putative transport ATPase from Streptomyces coelicolor (1472 aa); etc. C-terminal region similar to other ATPases from Mycobacteri [...] | 0.554 |
Rv3008 | ctpI | Rv3008 | Rv0107c | Hypothetical protein; Rv3008, (MTV012.22), len: 207 aa (start uncertain). Hypothetical unknown protein. | Rv0107c, (MTCY251.26c, MTV031.01c), len: 1632 aa. Probable ctpI, cation-transporting ATPase I P-type, highly similar to NP_302704.1|NC_002677 probable cation transport ATPase from Mycobacterium leprae (1609 aa); and similar to others e.g. CAB69720.1|AL137166 putative transport ATPase from Streptomyces coelicolor (1472 aa); ATA1_SYNY|P37367 cation-transporting ATPase pma1 from Synechocystis sp. (915 aa), FASTA scores: opt: 603, E(): 6.6e-29, (32.4% identity in 710 aa overlap); etc. Also similar to MTCY39.21c and MTCY22G10.22c from Mycobacterium tuberculosis, FASTA score: (34.4% identity [...] | 0.543 |
Rv3008 | panD | Rv3008 | Rv3601c | Hypothetical protein; Rv3008, (MTV012.22), len: 207 aa (start uncertain). Hypothetical unknown protein. | Probable aspartate 1-decarboxylase precursor PanD (aspartate alpha-decarboxylase); Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine; Belongs to the PanD family. | 0.525 |
Rv3008 | proZ | Rv3008 | Rv3756c | Hypothetical protein; Rv3008, (MTV012.22), len: 207 aa (start uncertain). Hypothetical unknown protein. | Rv3756c, (MTV025.104c), len: 239 aa. Possible proZ,osmoprotectant transport integral membrane protein ABC transporter (see citation below), similar to osmoprotection proteins (proW, proZ) involved in glycine betaine/L-proline/choline transport, e.g. BAB58609|Q99RI4|OPUCB|SA2236|SAV2447 OPUCB protein (probable glycine betaine/carnitine/choline ABC transporter) from Staphylococcus aureus (211 aa) FASTA scores: opt: 434, E(): 2.5e-18, (36.6% identity in 194 aa overlap); Q45461|OPBB_BACSU|OPUBB|prow choline transport system permease protein (mediate the uptake of choline for synthesis of t [...] | 0.809 |
ctpE | Rv3008 | Rv0908 | Rv3008 | Probable metal cation transporter ATPase P-type CtpE; P-type ATPase involved in specific uptake of calcium. | Hypothetical protein; Rv3008, (MTV012.22), len: 207 aa (start uncertain). Hypothetical unknown protein. | 0.546 |