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lipY lipY tgs4 tgs4 Rv3480c Rv3480c tgs1 tgs1 Rv2285 Rv2285 Rv3087 Rv3087 Rv0895 Rv0895 tgs2 tgs2 Rv3740c Rv3740c Rv1425 Rv1425 Rv1760 Rv1760
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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lipYTriacylglycerol lipase; Responsible for the utilization of stored long-chain triacylglycerol (TG) during dormancy and reactivation stage of the infection cycle. Catalyzes the hydrolysis of long-chain triacylglycerol with high specific activity; In the C-terminal section; belongs to the 'GDXG' lipolytic enzyme family. (437 aa)    
Predicted Functional Partners:
tgs4
Putative triacylglycerol synthase (diacylglycerol acyltransferase) Tgs4; Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH. Upon expression in E.coli functions as a triacylglycerol synthase, making triacylglycerol (TG) from diolein and long-chain fatty acyl-CoA. Has very weak wax synthase activity, incorporating palmityl alcohol into wax esters in the presence of palmitoyl-CoA.
  
  
 0.927
Rv3480c
Possible triacylglycerol synthase (diacylglycerol acyltransferase); Upon expression in E.coli has a weak triacylglycerol synthase function, making triacylglycerol (TG) from diolein and long-chain fatty acyl-CoA. Also functions weakly as a wax synthase, as it incorporates palmityl alcohol into wax esters in the presence of palmitoyl-CoA.
 
 
 0.926
tgs1
Triacylglycerol synthase (diacylglycerol acyltransferase) Tgs1; Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for storage lipid synthesis (Probable).
    
 0.925
Rv2285
Possible triacylglycerol synthase (diacylglycerol acyltransferase); Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for storage lipid synthesis (By similarity).
 
 
  0.923
Rv3087
Possible triacylglycerol synthase (diacylglycerol acyltransferase); Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH. Upon expression in E.coli functions weakly as a triacylglycerol synthase, making triacylglycerol (TG) from diolein and long-chain fatty acyl-CoA. Has no wax synthase activity.
 
 
  0.923
Rv0895
Possible triacylglycerol synthase (diacylglycerol acyltransferase); Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for storage lipid synthesis (By similarity).
 
  
  0.921
tgs2
Putative triacylglycerol synthase (diacylglycerol acyltransferase) Tgs2; Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for storage lipid synthesis (By similarity).
 
  
 0.919
Rv3740c
Possible triacylglycerol synthase (diacylglycerol acyltransferase); Upon expression in E.coli has a weak triacylglycerol synthase function, making triacylglycerol (TG) from diolein and long-chain fatty acyl-CoA. Also functions weakly as a wax synthase, as it incorporates palmityl alcohol into wax esters in the presence of palmitoyl-CoA.
 
  
  0.919
Rv1425
Possible triacylglycerol synthase (diacylglycerol acyltransferase); Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for storage lipid synthesis (By similarity).
 
  
  0.915
Rv1760
Possible triacylglycerol synthase (diacylglycerol acyltransferase); Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for storage lipid synthesis (By similarity).
 
  
  0.914
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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