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rsbW rsbW sigF sigF Rv1364c Rv1364c rsfA rsfA rsfB rsfB Rv1904 Rv1904 Rv2638 Rv2638 usfY usfY Rv1354c Rv1354c Rv0516c Rv0516c fbiC fbiC
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
Predicted Interactions
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gene co-occurrence
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textmining
co-expression
protein homology
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rsbWAnti-sigma factor RsbW (sigma negative effector); A cognate anti-sigma factor for alternative sigma factor SigF. Alternative sigma factors are held in an inactive form by an anti-sigma factor. Binds ATP and GTP, may hydrolyze both. (145 aa)    
Predicted Functional Partners:
sigF
Alternative RNA polymerase sigma factor SigF; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Held in an inactive form by a cognate anti-sigma factor RsbW (UsfX) until released. Increased expression decreases growth rate, and after 3 days increases the expression of 51 loci encoding 33 protein- coding genes as well as some non-coding RNA.
 
 
 0.998
Rv1364c
Rv1364c, (MTCY02B10.28c), len: 653 aa. Possible sigma factor regulatory protein, some similarity to RSBU_BACSU|P40399 sigma factor sibg regulation protein from Bacillus subtilis (335 aa), FASTA scores: opt: 224, E(): 2e-07, (25.8% identity in 244 aa overlap). Also known as mursiF.
  
 
 0.990
rsfA
Anti-anti-sigma factor RsfA (anti-sigma factor antagonist) (regulator of sigma F A); Positive, redox-sensitive regulator of sigma-F (SigF) activity. When reduced binds to anti-sigma-F factor RsbW (UsfX) preventing its binding to SigF, thus activating transcription. Belongs to the anti-sigma-factor antagonist family.
 
 
 0.952
rsfB
Anti-anti-sigma factor RsfB (anti-sigma factor antagonist) (regulator of sigma F B); Positive regulator of sigma-F (SigF) activity. Binds to anti- sigma-F factor RsbW (UsfX) preventing its binding to SigF, thus activating transcription.
 
 
 0.952
Rv1904
Rv1904, (MTCY180.14c), len: 143 aa. Conserved hypothetical protein, some similarity to other hypothetical Mycobacterium tuberculosis proteins e.g. Rv2638|MTCY441.08|P71937 (148 aa), FASTA results: opt: 456,E(): 2.7e-23, (52.8% identity in 125 aa overlap); Rv1365|Q11035 (128 aa), FASTA results: opt: 393, E(): 1.4e-19, (48.8% identity in 123 aa overlap); and Rv3687c. Also weak similarity to Q9WVX8|RSBV_STRCO anti-sigma B factor antagonist from Streptomyces coelicolor (113 aa).
 
 
 0.913
Rv2638
Rv2638, (MTCY441.08), len: 148 aa. Conserved hypothetical protein, similar in part to Q9WVX8|RSBV_STRCO|bldg|SCH5.12c anti-sigma B factor antagonist from Streptomyces coelicolor (113 aa), FASTA scores: opt: 162, E(): 0.00066, (31.8% identity in 110 aa overlap); and showing weak similarity with various proteins e.g. O69205 hypothetical 13.4 KDA protein from Actinosynnema pretiosum (subsp. auranticum) (128 aa), FASTA scores: opt: 157, E(): 0.0016, (29.8% identity in 114 aa overlap); Q9RJ93|SCF91.32 putative anti-sigma factor antagonist from Streptomyces coelicolor (183 aa), FASTA scores: [...]
 
 
 0.893
usfY
Putative protein UsfY; Rv3288c, (MTCY71.28c), len: 137 aa. UsfY, putative protein (see citation below). Has no significant homologues. May not be contranscribed with the usfX and sigF proteins.
  
  
 0.858
Rv1354c
Conserved hypothetical protein; Rv1354c, (MTCY02B10.18c), len: 623 aa. Conserved hypothetical protein, similar to many hypothetical proteins e.g. the C-terminus of G1001455 Synechocystis sp. (1244 aa), FASTA scores: opt: 933, E(): 0, (36.8% identity in 462 aa overlap); also similar to Rv1357c|MTCY02B10.21c (34.0% identity in 253 aa overlap).
  
 
 0.846
Rv0516c
Possible anti-anti-sigma factor; Rv0516c, (MTCY20G10.06c), len: 158 aa. Possible anti-anti-sigma factor, showing some similarity to Rv1365c|MTCY02B10_29 from Mycobacterium tuberculosis (128 aa), FASTA scores: E(): 0.0012, (27.4% identity in 124 aa overlap).
  
 
 0.844
fbiC
Probable F420 biosynthesis protein FbiC; Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine; In the C-terminal section; belongs to the radical SAM superfamily. CofH family.
 
    0.780
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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