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Rv3294c Rv3294c Rv2810c Rv2810c Rv3295 Rv3295 lprP lprP nei nei lhr lhr Rv0919 Rv0919
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
Rv3294cRv3294c, len: 269 aa. Conserved hypothetical protein, similar to several conserved hypothetical proteins from Mycobacterium tuberculosis: O07781|Rv0597c (411 aa),FASTA scores: opt: 682, E(): 3.6e-37, (44.85% identity in 243 aa overlap); O53329|Rv3179 (454 aa), FASTA scores: opt: 561, E(): 3.3e-29, (42.20% identity in 218 aa overlap); Q10849|YK08_MYCTU|Rv2008c (441 aa), FASTA scores: opt: 194,E(): 3.9e-05, (30.10% identity in 239 aa overlap). Also some similarity with proteins from other organisms. Replace previous Rv3294 on opposite strand. (269 aa)    
Predicted Functional Partners:
Rv2810c
Probable transposase; Rv2810c, (MTCY16B7.33), len: 133 aa. Probable transposase for IS1555, similar to C-terminal domain of transposases for defective IS1555 e.g. Q9LCS0|TNPA transposase from Arthrobacter sp. TM1 (435 aa), FASTA scores: opt: 294, E(): 1.8e-13, (55.1% identity in 98 aa overlap); Q50440|TNPA insertion element TNPR and TNPA gene from Mycobacterium smegmatis (413 aa), FASTA scores: opt: 274, E(): 4.7e-12, (56.25% identity in 96 aa overlap); etc. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007).
   
    0.733
Rv3295
Probable transcriptional regulatory protein (probably TetR-family); Rv3295, (MTCY71.35), len: 221 aa. Probable transcriptional regulator TetR-family, equivalent to Q9CCL4|ML0717 putative TetR-family transcriptional regulator from Mycobacterium leprae (223 aa), FASTA scores: opt: 1260, E(): 7.2e-75, (85.45% identity in 220 aa overlap). Also highly similar to other streptomyces regulators e.g. Q9RD77|SCF43.11 from Streptomyces coelicolor (205 aa), FASTA scores: opt: 442, E(): 9.8e-22,(38.6% identity in 202 aa overlap); Q9RKY8|SC6D7.09 from Streptomyces coelicolor (220 aa), FASTA scores: [...]
  
    0.610
lprP
Rv0962c, (MTCY10D7.12), len: 224 aa. Possible lprP,lipoprotein. Contains possible N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
   
    0.553
nei
Probable endonuclease VIII Nei; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity). Complements an E.coli nei nth double mutant.
  
    0.493
lhr
Rv3296, (MTCY71.36), len: 1513 aa. Probable lhr,ATP-dependent helicase, similar to others e.g. P30015|LHR_ECOLI|RHLF|B1653 from Escherichia coli stain K12 (1538 aa), FASTA scores: opt: 2930, E(): 1.5e-159, (47.55% identity in 1569 aa overlap); AAG56642|LHR from Escherichia coli stain O157:H7 EDL933 (1538 aa), FASTA scores: opt: 2930, E(): 1.5e-159, (47.6% identity in 1561 aa overlap); O86821|SC7C7.16c from Streptomyces coelicolor (1690 aa),FASTA scores: opt: 2919, E(): 7e-159, (53.55% identity in 1703 aa overlap); Q9HYW9|PA3272 from Pseudomonas aeruginosa (1448 aa), FASTA scores: opt: [...]
  
    0.469
Rv0919
GCN5-related N-acetyltransferase; Rv0919, (MTCY21C12.13), len: 166 aa. Probable acetyltransferase. Contains GNAT (Gcn5-related N-acetyltransferase) domain. See Vetting et al. 2005. Some similarity to Q50115 hypothetical protein from Mycobacterium leprae (90 aa), FASTA scores: opt: 243, E(): 5.3e-11, (56.5% identity in 85 aa overlap). Alternative nucleotide at position 1025106 (T->C; F141F) has been observed.
 
    0.443
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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