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cdd cdd deoA deoA add add deoD deoD upp upp Rv3312c Rv3312c deoC deoC sdhC sdhC sdhD sdhD sdhA sdhA sdhB sdhB
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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experimentally determined
Predicted Interactions
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gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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cddProbable cytidine deaminase Cdd (cytidine aminohydrolase) (cytidine nucleoside deaminase); Recycles cytidine and 2-deoxycytidine for uridine and 2- deoxyuridine synthesis, respectively. Catalyzes the hydrolytic deamination of cytidine and 2-deoxycytidine to form, respectively, uridine and 2-deoxyuridine. (133 aa)    
Predicted Functional Partners:
deoA
Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase); The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.
 
 0.999
add
Rv3313c, (MTV016.13), len: 365 aa. Probable add,adenosine deaminase, equivalent to Q9CCL9|add|ML0700 putative adenosine deaminase from Mycobacterium leprae (362 aa), FASTA scores: opt: 2097, E(): 1.4e-127, (88.2% identity in 356 aa overlap). Also similar to many e.g. Q9AK25|2SCK8.27 from Streptomyces coelicolor (396 aa),FASTA scores: opt: 1578, E(): 3.7e-94, (66.65% identity in 360 aa overlap); Q17747|C06G3.5 from Caenorhabditis elegans (349 aa), FASTA scores: opt: 435, E(): 1.1e-20, (29.6% identity in 348 aa overlap); P22333|ADD_ECOLI|B1623 from Escherichia coli strain K12 (333 aa), F [...]
 
  
 0.976
deoD
Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP); The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Cleaves guanosine, inosine, 2'-deoxyguanosine and 2'-deoxyinosine.
 
 
 0.971
upp
Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate.
 
  
 0.913
Rv3312c
Rv3312c, (MTV016.11), len: 308 aa. Hypothetical protein, similar to various proteins (principally hypothetical unknowns or hydrolases) e.g. Q9M9P2|T17B22.7 hypothetical protein from Arabidopsis thaliana (Mouse-ear cress) (326 aa), FASTA scores: opt: 261, E(): 2.6e-09,(27.55% identity in 323 aa overlap); Q9FWB6 putative alpha/beta hydrolase from Oryza sativa (Rice) (354 aa),FASTA scores: opt: 241, E(): 4.9e-08, (28.9% identity in 301 aa overlap) (note that Q9FWB6 correspond to Q9FWB5 putative alpha/beta hydrolase (353 aa) but longer 1 aa; and to Q9AUW9 hypothetical protein (332 aa) but [...]
  
  
 0.861
deoC
Probable deoxyribose-phosphate aldolase DeoC (phosphodeoxyriboaldolase) (deoxyriboaldolase); Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate.
 
  
 0.765
sdhC
Succinate dehydrogenase 2 membrane subunit SdhC; Membrane-anchoring subunit of succinate dehydrogenase 2 (Sdh2). Sdh2 may catalyze the two-electron oxidation of succinate to fumarate with a corresponding reduction of quinone to quinol under low oxygen conditions, when the primary aerobic succinate dehydrogenase (Sdh1) is inhibited. Sdh2 seems to be the generator of the proton motive force (PMF) under hypoxia.
  
    0.753
sdhD
Rv3317, (MTV016.17), len: 144 aa. Probable sdhD,membrane anchor of succinate dehydrogenase SdhD subunit, equivalent (but shorter 19 aa) to Q49915|SDHD|ML0698|L308_F1_25 putative succinate dehydrogenase hydrophobic membrane anchor protein from Mycobacterium leprae (163 aa), FASTA scores: opt: 878, E(): 1.9e-51, (85.2% identity in 142 aa overlap). Also similar to others e.g. Q9KZ89|SC5G8.25c from Streptomyces coelicolor (160 aa), FASTA scores: opt: 553, E(): 6.6e-30,(58.85% identity in 141 aa overlap); Q9RVR9|DR0953 from Deinococcus radiodurans (125 aa), FASTA scores: opt: 251,E(): 5.5e- [...]
  
    0.751
sdhA
Rv3318, (MTV016.18), len: 590 aa. Probable sdhA,flavoprotein of succinate dehydrogenase SdhA subunit,equivalent to Q9CCM1|SDHA|ML0697 succinate dehydrogenase flavoprotein subunit from Mycobacterium leprae (584 aa),FASTA scores: opt: 3657, E(): 1.2e-217, (92.55% identity in 590 aa overlap). Also highly similar to others e.g. Q9KZ90|DHSA from Streptomyces coelicolor (584 aa), FASTA scores: opt: 2813, E(): 1.1e-165, (70.5% identity in 586 aa overlap); Q9RVS0|DR0952 from Deinococcus radiodurans (583 aa), FASTA scores: opt: 2203, E(): 4.1e-128, (57.35% identity in 593 aa overlap); P31038|DH [...]
  
    0.680
sdhB
Succinate dehydrogenase / fumarate reductase, iron-sulfur subunit; Rv3319, (MTV016.19), len: 263 aa. Probable sdhB,iron-sulphur protein succinate dehydrogenase SdhB subunit, equivalent to Q49916|SDHB|ML0696|L308_F1_28 succinate dehydrogenase iron-sulfur protein from Mycobacterium leprae (264 aa), FASTA scores: opt: 1678, E(): 4.7e-99, (89.8% identity in 264 aa overlap). Also highly similar to other e.g. Q9KZ91|DHSB from Streptomyces coelicolor (257 aa),FASTA scores: opt: 1125, E(): 4.6e-64, (64.1% identity in 262 aa overlap); Q9RVS1|DR0951 from Deinococcus radiodurans (264 aa), FASTA s [...]
  
    0.679
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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