node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rv3657c | eccB4 | Rv3657c | Rv3450c | Rv3657c, (MTV025.005c), len: 191 aa. Possible conserved membrane protein, rich in ala residues, similar to Q9X919|SCH5.17c putative integral membrane protein from Streptomyces coelicolor (267 aa), FASTA scores: opt: 324,E(): 4.7e-12, (40.9% identity in 154 aa overlap). | ESX conserved component EccB4. ESX-4 type VII secretion system protein. Probable membrane protein; An ATPase (By similarity). | 0.802 |
cut3 | eccA2 | Rv3451 | Rv3884c | Rv3451, (MTCY13E12.04), len: 262 aa. Probable cut3,cutinase precursor, similar to others e.g. Q9KK87 from Mycobacterium avium (220 aa), FASTA scores: opt: 540, E(): 3.5e-24, (43.4% identity in 219 aa overlap); Q00298|CUTI_BOTCI|CUTA from Botrytis cinerea (Botryotinia fuckeliana) (202 aa), FASTA scores: opt: 214, E(): 2e-05,(31.45% identity in 210 aa overlap); Q9Y7G8 from Pyrenopeziza brassicae (203 aa), FASTA scores: opt: 203,E(): 8.5e-05, (31.05% identity in 190 aa overlap); P29292|CUTI_ASCRA from Ascochyta rabiei (223 aa), FASTA scores: opt: 155, E(): 0.054, (31.65% identity in 120 a [...] | ESX-2 secretion system protein EccA2; Shows ATPase activity. Could provide energy for export of ESX-2 substrates (By similarity). | 0.469 |
cut3 | eccB4 | Rv3451 | Rv3450c | Rv3451, (MTCY13E12.04), len: 262 aa. Probable cut3,cutinase precursor, similar to others e.g. Q9KK87 from Mycobacterium avium (220 aa), FASTA scores: opt: 540, E(): 3.5e-24, (43.4% identity in 219 aa overlap); Q00298|CUTI_BOTCI|CUTA from Botrytis cinerea (Botryotinia fuckeliana) (202 aa), FASTA scores: opt: 214, E(): 2e-05,(31.45% identity in 210 aa overlap); Q9Y7G8 from Pyrenopeziza brassicae (203 aa), FASTA scores: opt: 203,E(): 8.5e-05, (31.05% identity in 190 aa overlap); P29292|CUTI_ASCRA from Ascochyta rabiei (223 aa), FASTA scores: opt: 155, E(): 0.054, (31.65% identity in 120 a [...] | ESX conserved component EccB4. ESX-4 type VII secretion system protein. Probable membrane protein; An ATPase (By similarity). | 0.770 |
cut3 | mycP1 | Rv3451 | Rv3883c | Rv3451, (MTCY13E12.04), len: 262 aa. Probable cut3,cutinase precursor, similar to others e.g. Q9KK87 from Mycobacterium avium (220 aa), FASTA scores: opt: 540, E(): 3.5e-24, (43.4% identity in 219 aa overlap); Q00298|CUTI_BOTCI|CUTA from Botrytis cinerea (Botryotinia fuckeliana) (202 aa), FASTA scores: opt: 214, E(): 2e-05,(31.45% identity in 210 aa overlap); Q9Y7G8 from Pyrenopeziza brassicae (203 aa), FASTA scores: opt: 203,E(): 8.5e-05, (31.05% identity in 190 aa overlap); P29292|CUTI_ASCRA from Ascochyta rabiei (223 aa), FASTA scores: opt: 155, E(): 0.054, (31.65% identity in 120 a [...] | Mycosin-1; May play a dual role in regulation of ESX-1 secretion and virulence. Acts as a protease that cleaves EspB. Essential for ESX-1 function, required for early replication in macrophages and full virulence in mice; Belongs to the peptidase S8 family. | 0.445 |
cut3 | mycP2 | Rv3451 | Rv3886c | Rv3451, (MTCY13E12.04), len: 262 aa. Probable cut3,cutinase precursor, similar to others e.g. Q9KK87 from Mycobacterium avium (220 aa), FASTA scores: opt: 540, E(): 3.5e-24, (43.4% identity in 219 aa overlap); Q00298|CUTI_BOTCI|CUTA from Botrytis cinerea (Botryotinia fuckeliana) (202 aa), FASTA scores: opt: 214, E(): 2e-05,(31.45% identity in 210 aa overlap); Q9Y7G8 from Pyrenopeziza brassicae (203 aa), FASTA scores: opt: 203,E(): 8.5e-05, (31.05% identity in 190 aa overlap); P29292|CUTI_ASCRA from Ascochyta rabiei (223 aa), FASTA scores: opt: 155, E(): 0.054, (31.65% identity in 120 a [...] | Mycosin-2; Rv3886c, (MTCY15F10.26), len: 550 aa. Probable mycP2, ala-, pro-rich membrane-anchored serine protease (mycosin) (see citation below), highly similar to Q9CBV3|ML1538 possible protease from Mycobacterium leprae (567 aa), FASTA scores: opt: 1034, E(): 3.9e-32, (43.5% identity in 575 aa overlap); and highly similar, but with gaps, to several putative proteases from Mycobacterium leprae; O33076|ML0041|MLCB628.04 (446 aa), FASTA scores: opt: 860, E(): 1.1e-25, (38.65% identity in 538 aa overlap); Q9CD36|ML2528 (475 aa) (475 aa), FASTA scores: opt: 413, E(): 7.1e-09, (37.7% ident [...] | 0.443 |
eccA2 | cut3 | Rv3884c | Rv3451 | ESX-2 secretion system protein EccA2; Shows ATPase activity. Could provide energy for export of ESX-2 substrates (By similarity). | Rv3451, (MTCY13E12.04), len: 262 aa. Probable cut3,cutinase precursor, similar to others e.g. Q9KK87 from Mycobacterium avium (220 aa), FASTA scores: opt: 540, E(): 3.5e-24, (43.4% identity in 219 aa overlap); Q00298|CUTI_BOTCI|CUTA from Botrytis cinerea (Botryotinia fuckeliana) (202 aa), FASTA scores: opt: 214, E(): 2e-05,(31.45% identity in 210 aa overlap); Q9Y7G8 from Pyrenopeziza brassicae (203 aa), FASTA scores: opt: 203,E(): 8.5e-05, (31.05% identity in 190 aa overlap); P29292|CUTI_ASCRA from Ascochyta rabiei (223 aa), FASTA scores: opt: 155, E(): 0.054, (31.65% identity in 120 a [...] | 0.469 |
eccA2 | eccB4 | Rv3884c | Rv3450c | ESX-2 secretion system protein EccA2; Shows ATPase activity. Could provide energy for export of ESX-2 substrates (By similarity). | ESX conserved component EccB4. ESX-4 type VII secretion system protein. Probable membrane protein; An ATPase (By similarity). | 0.897 |
eccA2 | eccE3 | Rv3884c | Rv0292 | ESX-2 secretion system protein EccA2; Shows ATPase activity. Could provide energy for export of ESX-2 substrates (By similarity). | ESX-3 secretion system protein EccE3; Part of the ESX-3 specialized secretion system, which is important for iron and zinc uptake or homeostasis. Belongs to the EccE family. | 0.682 |
eccA2 | espG1 | Rv3884c | Rv3866 | ESX-2 secretion system protein EccA2; Shows ATPase activity. Could provide energy for export of ESX-2 substrates (By similarity). | ESX-1 secretion-associated protein EspG1; Specific chaperone for cognate PE/PPE proteins. Plays an important role in preventing aggregation of PE/PPE dimers. Belongs to the EspG family. | 0.752 |
eccA2 | esxT | Rv3884c | Rv3444c | ESX-2 secretion system protein EccA2; Shows ATPase activity. Could provide energy for export of ESX-2 substrates (By similarity). | Putative ESAT-6 like protein EsxT; Induces apoptosis of host cells via activation of NF-kappa-B. | 0.816 |
eccA2 | mycP1 | Rv3884c | Rv3883c | ESX-2 secretion system protein EccA2; Shows ATPase activity. Could provide energy for export of ESX-2 substrates (By similarity). | Mycosin-1; May play a dual role in regulation of ESX-1 secretion and virulence. Acts as a protease that cleaves EspB. Essential for ESX-1 function, required for early replication in macrophages and full virulence in mice; Belongs to the peptidase S8 family. | 0.912 |
eccA2 | mycP2 | Rv3884c | Rv3886c | ESX-2 secretion system protein EccA2; Shows ATPase activity. Could provide energy for export of ESX-2 substrates (By similarity). | Mycosin-2; Rv3886c, (MTCY15F10.26), len: 550 aa. Probable mycP2, ala-, pro-rich membrane-anchored serine protease (mycosin) (see citation below), highly similar to Q9CBV3|ML1538 possible protease from Mycobacterium leprae (567 aa), FASTA scores: opt: 1034, E(): 3.9e-32, (43.5% identity in 575 aa overlap); and highly similar, but with gaps, to several putative proteases from Mycobacterium leprae; O33076|ML0041|MLCB628.04 (446 aa), FASTA scores: opt: 860, E(): 1.1e-25, (38.65% identity in 538 aa overlap); Q9CD36|ML2528 (475 aa) (475 aa), FASTA scores: opt: 413, E(): 7.1e-09, (37.7% ident [...] | 0.845 |
eccB4 | Rv3657c | Rv3450c | Rv3657c | ESX conserved component EccB4. ESX-4 type VII secretion system protein. Probable membrane protein; An ATPase (By similarity). | Rv3657c, (MTV025.005c), len: 191 aa. Possible conserved membrane protein, rich in ala residues, similar to Q9X919|SCH5.17c putative integral membrane protein from Streptomyces coelicolor (267 aa), FASTA scores: opt: 324,E(): 4.7e-12, (40.9% identity in 154 aa overlap). | 0.802 |
eccB4 | cut3 | Rv3450c | Rv3451 | ESX conserved component EccB4. ESX-4 type VII secretion system protein. Probable membrane protein; An ATPase (By similarity). | Rv3451, (MTCY13E12.04), len: 262 aa. Probable cut3,cutinase precursor, similar to others e.g. Q9KK87 from Mycobacterium avium (220 aa), FASTA scores: opt: 540, E(): 3.5e-24, (43.4% identity in 219 aa overlap); Q00298|CUTI_BOTCI|CUTA from Botrytis cinerea (Botryotinia fuckeliana) (202 aa), FASTA scores: opt: 214, E(): 2e-05,(31.45% identity in 210 aa overlap); Q9Y7G8 from Pyrenopeziza brassicae (203 aa), FASTA scores: opt: 203,E(): 8.5e-05, (31.05% identity in 190 aa overlap); P29292|CUTI_ASCRA from Ascochyta rabiei (223 aa), FASTA scores: opt: 155, E(): 0.054, (31.65% identity in 120 a [...] | 0.770 |
eccB4 | eccA2 | Rv3450c | Rv3884c | ESX conserved component EccB4. ESX-4 type VII secretion system protein. Probable membrane protein; An ATPase (By similarity). | ESX-2 secretion system protein EccA2; Shows ATPase activity. Could provide energy for export of ESX-2 substrates (By similarity). | 0.897 |
eccB4 | eccC4 | Rv3450c | Rv3447c | ESX conserved component EccB4. ESX-4 type VII secretion system protein. Probable membrane protein; An ATPase (By similarity). | Rv3447c, (MTCY77.19c), len: 1236 aa. EccC4, esx conserved component, ESX-4 type VII secretion system protein, probable membrane protein, similar to various bacterial proteins e.g. O86653|SC3C3.20c ATP/GTP binding protein from Streptomyces coelicolor (1321 aa), FASTA scores: opt: 1186, E(): 1.9e-60, (42.9% identity in 1312 aa overlap); Q9L0T6|SCD35.15c from Streptomyces coelicolor (1525 aa), FASTA scores: opt: 932, E(): 9.2e-46, (27.2% identity in 1374 aa overlap); Q9CD30|ML2535 hypothetical protein from Mycobacterium leprae (1329 aa), FASTA scores: opt: 910, E(): 1.5e-44, (34.4% identi [...] | 0.829 |
eccB4 | eccD4 | Rv3450c | Rv3448 | ESX conserved component EccB4. ESX-4 type VII secretion system protein. Probable membrane protein; An ATPase (By similarity). | ESX-4 secretion system protein eccD4; Rv3448, (MTCY77.20), len: 467 aa. EccD4, esx conserved component, ESX-4 type VII secretion system protein, probable integral membrane protein, showing some similarity with Q9CD35|ML2529 from Mycobacterium leprae (485 aa), FASTA scores: opt: 371, E(): 3.6e-14, (27.25% identity in 481 aa overlap); and two proteins from Mycobacterium tuberculosis O86362|Rv0290|MTV035.18 (472 aa), FASTA scores: opt: 429, E(): 1.6e-17, (28.6% identity in 479 aa overlap); and O05457|Rv3887c|MTCY15F10.25 (509 aa), FASTA scores: opt: 203, E(): 0.00019, (25.6% identity in 4 [...] | 0.827 |
eccB4 | eccE3 | Rv3450c | Rv0292 | ESX conserved component EccB4. ESX-4 type VII secretion system protein. Probable membrane protein; An ATPase (By similarity). | ESX-3 secretion system protein EccE3; Part of the ESX-3 specialized secretion system, which is important for iron and zinc uptake or homeostasis. Belongs to the EccE family. | 0.774 |
eccB4 | espG1 | Rv3450c | Rv3866 | ESX conserved component EccB4. ESX-4 type VII secretion system protein. Probable membrane protein; An ATPase (By similarity). | ESX-1 secretion-associated protein EspG1; Specific chaperone for cognate PE/PPE proteins. Plays an important role in preventing aggregation of PE/PPE dimers. Belongs to the EspG family. | 0.782 |
eccB4 | esxT | Rv3450c | Rv3444c | ESX conserved component EccB4. ESX-4 type VII secretion system protein. Probable membrane protein; An ATPase (By similarity). | Putative ESAT-6 like protein EsxT; Induces apoptosis of host cells via activation of NF-kappa-B. | 0.854 |