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mhpE mhpE hsaG hsaG ilvB2 ilvB2 hsaE hsaE hsaF hsaF sseB sseB lppO lppO Rv3468c Rv3468c Rv2650c Rv2650c Rv0094c Rv0094c Rv3467 Rv3467
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
mhpERv3469c, (MTCY13E12.22c), len: 336 aa. Probable mhpE, 4-hydroxy-2-oxovalerate aldolase, similar to others (principally from Pseudomonas species) e.g. Q99PZ1|SCP1.301|SCP1.53c from Streptomyces coelicolor (338 aa), FASTA scores: opt: 615, E(): 7.9e-31, (37.65% identity in 332 aa overlap); Q9X9Q0|NIKB NIKB protein (see Bruntner et al., 1999) from Streptomyces tendae (357 aa), FASTA scores: opt: 571, E(): 4.4e-28, (34.5% identity in 339 aa overlap); P51014|BPHF_PSES1 from Pseudomonas sp. strain KKS102 (352 aa), FASTA scores: opt: 549, E(): 9.9e-27,(31.2% identity in 314 aa overlap); Q5198 [...] (336 aa)    
Predicted Functional Partners:
hsaG
Probable acetaldehyde dehydrogenase (acetaldehyde dehydrogenase [acetylating]); Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.
 
 0.999
ilvB2
Putative acetolactate synthase large subunit IlvB2; Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine. Belongs to the TPP enzyme family.
 
 
 0.986
hsaE
Probable hydratase; Rv3536c, (MTCY03C7.20), len: 261 aa. Probable hsaE,hydratase, 2-oxo-hepta-3-ene-1,7-dioate hydratase or 2-keto-4-pentenoate hydratase. Indeed, highly similar to many 2-oxo-hepta-3-ene-1,7-dioate hydratases e.g. Q9CKS2|HPAH|PM1534 from Pasteurella multocida (267 aa) FASTA scores: opt: 743, E(): 1.5e-39, (45.5% identity in 266 aa overlap) Q9RZ31|DRA0122 from Deinococcus radiodurans (268 aa), FASTA scores: opt: 709, E(): 2e-37, (45.5% identity in 266 aa overlap); Q9HWQ4|HPCG|PA4127 from Pseudomonas aeruginosa (267 aa), FASTA scores: opt: 703,E(): 4.8e-37, (45.1% identi [...]
 
 
 0.985
hsaF
Probable 4-hydroxy-2-oxovalerate aldolase (HOA); Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family.
  
 
 
0.923
sseB
Rv2291, (MTCY339.19c), len: 284 aa. Probable sseB,thiosulfate sulfurtransferase. Very similar to thiosulfate sulfurtransferas/rhodanese from Streptomyces coelicolor AL00920 4|SC9B10_21 (283 aa) opt: 765, E(): 0; Smith-Waterman score: 765; 46.9% identity in 286 aa overlap, similar to THTR_ECOLI P31142 putative thiosulfate sulfurtransferase (280 aa), FASTA scores, opt: 478, E(): 1e-23, (35.1% identity in 265 aa overlap).
  
  
 0.908
lppO
Rv2290, (MTCY339.20c), len: 171 aa. Probable lppO,conserved lipoprotein, similar to Rv3763, 19KD_MYCTU P11572 19 kDa lipoprotein antigen precursor (159 aa) FASTA scores,opt: 119, E (): 1.3, (25.6% identity in 164 aa overlap). Contains appropriately positioned PS00013 lipoprotein motif (with one mismatch). This region is a possible MT-complex-specific genomic island (See Becq et al.,2007).
   
  
 0.907
Rv3468c
Rv3468c, (MTCY13E12.21c), len: 364 aa. Possible dTDP-glucose-4,6-dehydratase, but experimental study shown that the purified protein didn't have dTDP-glucose dehydratase (rmlB) activity (see Ma et al., 2001). Similar to others e.g. O08246|MTME from Streptomyces argillaceus (331 aa), FASTA scores: opt: 238, E(): 1.2e-07, (29.65% identity in 344 aa overlap); Q9LFG7|F4P12_220 from Arabidopsis thaliana (Mouse-ear cress) (433 aa), FASTA scores: opt: 237, E(): 1.8e-07, (27.25% identity in 308 aa overlap); Q9LZI2|F26K9_260 from Arabidopsis thaliana (Mouse-ear cress) (445 aa), FASTA scores: op [...]
  
    0.906
Rv2650c
Rv2650c, (MTCY441.19), len: 479 aa. Possible phiRv2 prophage protein (capsid subunit) (see citation below),highly similar to O06614|Rv1576c|MTCY336.28 probable phiRv1 phage protein from Mycobacterium tuberculosis (473 aa),FASTA scores: opt: 2782, E(): 2.8e-159, (89.1% identity in 468 aa overlap).
   
  
 0.872
Rv0094c
Conserved hypothetical protein; Rv0094c, (MTCY251.13c), len: 317 aa. Member of 13E12 repeat family, showing some similarity to U15187|MLU15187_7 from Mycobacterium leprae (94 aa), FASTA score: (49.4% identity in 79 aa overlap).
   
  
 0.870
Rv3467
Rv3467, (MTCY13E12.20), len: 317 aa. Conserved hypothetical ORF in REP13E12 repeat, identical to ORF's from other REP13E12 copies e.g. MTCY251.13c, MTCI65.15c,MTCY09F9.19, cMTCY336.17. Also identical to Mycobacterium bovis Q50655 hypothetical 34.6 kDa protein (317 aa) in identical repeat.
   
  
 0.870
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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