node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rv0310c | cyp51 | Rv0310c | Rv0764c | Conserved protein; Rv0310c, (MTCY63.15c), len: 163 aa. Conserved protein, similar to some bile acid dehydratases e.g. P19412|BAIE_EUBSP|98749|D37844|1381566|AAC45413.1|U57489 bile acid-inducible operon protein E from Eubacterium sp (166 aa), FASTA scores: opt: 302, E(): 1e-11, (38.8% identity in 134 aa overlap); AAF22847.1|AF210152_4 bile acid 7a-dehydratase from Clostridium sp. (168 aa). | Lanosterol 14-alpha demethylase; Its precise biological substrate is not known. Catalyzes C14- demethylation of lanosterol, 24,25-dihydrolanosterol and obtusifoliol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol. | 0.480 |
Rv0310c | fdxD | Rv0310c | Rv3503c | Conserved protein; Rv0310c, (MTCY63.15c), len: 163 aa. Conserved protein, similar to some bile acid dehydratases e.g. P19412|BAIE_EUBSP|98749|D37844|1381566|AAC45413.1|U57489 bile acid-inducible operon protein E from Eubacterium sp (166 aa), FASTA scores: opt: 302, E(): 1e-11, (38.8% identity in 134 aa overlap); AAF22847.1|AF210152_4 bile acid 7a-dehydratase from Clostridium sp. (168 aa). | Rv3503c, (MTV023.10c), len: 63 aa. Probable fdxD,ferredoxin, equivalent to Q9R6Z5|B229_C3_226 hypothetical 9.3 KDA protein from Mycobacterium leprae (83 aa) FASTA scores: opt: 276, E(): 1.8e-13, (75.9% identity in 54 aa overlap). Also similar to several e.g. Q9R6Z5|PHDC from Nocardioides sp. strain KP7 (69 aa), FASTA scores: opt: 177, E(): 2.1e-06, (43.35% identity in 60 aa overlap); Q9X4X8|DITA3 dioxygenase DITA ferredoxin component from Pseudomonas abietaniphila (78 aa), FASTA scores: opt: 166,E(): 1.4e-05, (36.2% identity in 58 aa overlap); P00203|FER_MOOTH from Moorella thermoaceti [...] | 0.545 |
Rv0763c | cyp51 | Rv0763c | Rv0764c | Possible ferredoxin; Rv0763c, (MTCY369.08c), len: 68 aa. Possible ferredoxin, similar to others and related proteins e.g. P18324|FER1_STRGO|SUAB ferredoxin 1 (fd-1) from Streptomyces griseolus (68 aa); AAK31349.1|AF350429_2|AF350429 putative ferredoxin from Nocardioides sp (63 aa); AAK16536.1|AF331043_16|AF331043 phthalate dioxygenase ferredoxin subunit from Arthrobacter keyseri (64 aa); etc. Probably involved in electron transport for cytochrome P-450 system e.g. downstream ORF Rv0764c|MTCY369.09c probable cytochrome P450 51 from Mycobacterium tuberculosis (451 aa), FASTA scores: opt: [...] | Lanosterol 14-alpha demethylase; Its precise biological substrate is not known. Catalyzes C14- demethylation of lanosterol, 24,25-dihydrolanosterol and obtusifoliol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol. | 0.990 |
Rv0763c | fdxA | Rv0763c | Rv2007c | Possible ferredoxin; Rv0763c, (MTCY369.08c), len: 68 aa. Possible ferredoxin, similar to others and related proteins e.g. P18324|FER1_STRGO|SUAB ferredoxin 1 (fd-1) from Streptomyces griseolus (68 aa); AAK31349.1|AF350429_2|AF350429 putative ferredoxin from Nocardioides sp (63 aa); AAK16536.1|AF331043_16|AF331043 phthalate dioxygenase ferredoxin subunit from Arthrobacter keyseri (64 aa); etc. Probably involved in electron transport for cytochrome P-450 system e.g. downstream ORF Rv0764c|MTCY369.09c probable cytochrome P450 51 from Mycobacterium tuberculosis (451 aa), FASTA scores: opt: [...] | Ferredoxin FdxA; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. | 0.468 |
Rv0763c | fdxC | Rv0763c | Rv1177 | Possible ferredoxin; Rv0763c, (MTCY369.08c), len: 68 aa. Possible ferredoxin, similar to others and related proteins e.g. P18324|FER1_STRGO|SUAB ferredoxin 1 (fd-1) from Streptomyces griseolus (68 aa); AAK31349.1|AF350429_2|AF350429 putative ferredoxin from Nocardioides sp (63 aa); AAK16536.1|AF331043_16|AF331043 phthalate dioxygenase ferredoxin subunit from Arthrobacter keyseri (64 aa); etc. Probably involved in electron transport for cytochrome P-450 system e.g. downstream ORF Rv0764c|MTCY369.09c probable cytochrome P450 51 from Mycobacterium tuberculosis (451 aa), FASTA scores: opt: [...] | Probable ferredoxin FdxC; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. | 0.704 |
Rv0763c | fdxD | Rv0763c | Rv3503c | Possible ferredoxin; Rv0763c, (MTCY369.08c), len: 68 aa. Possible ferredoxin, similar to others and related proteins e.g. P18324|FER1_STRGO|SUAB ferredoxin 1 (fd-1) from Streptomyces griseolus (68 aa); AAK31349.1|AF350429_2|AF350429 putative ferredoxin from Nocardioides sp (63 aa); AAK16536.1|AF331043_16|AF331043 phthalate dioxygenase ferredoxin subunit from Arthrobacter keyseri (64 aa); etc. Probably involved in electron transport for cytochrome P-450 system e.g. downstream ORF Rv0764c|MTCY369.09c probable cytochrome P450 51 from Mycobacterium tuberculosis (451 aa), FASTA scores: opt: [...] | Rv3503c, (MTV023.10c), len: 63 aa. Probable fdxD,ferredoxin, equivalent to Q9R6Z5|B229_C3_226 hypothetical 9.3 KDA protein from Mycobacterium leprae (83 aa) FASTA scores: opt: 276, E(): 1.8e-13, (75.9% identity in 54 aa overlap). Also similar to several e.g. Q9R6Z5|PHDC from Nocardioides sp. strain KP7 (69 aa), FASTA scores: opt: 177, E(): 2.1e-06, (43.35% identity in 60 aa overlap); Q9X4X8|DITA3 dioxygenase DITA ferredoxin component from Pseudomonas abietaniphila (78 aa), FASTA scores: opt: 166,E(): 1.4e-05, (36.2% identity in 58 aa overlap); P00203|FER_MOOTH from Moorella thermoaceti [...] | 0.886 |
Rv0763c | fprA | Rv0763c | Rv3106 | Possible ferredoxin; Rv0763c, (MTCY369.08c), len: 68 aa. Possible ferredoxin, similar to others and related proteins e.g. P18324|FER1_STRGO|SUAB ferredoxin 1 (fd-1) from Streptomyces griseolus (68 aa); AAK31349.1|AF350429_2|AF350429 putative ferredoxin from Nocardioides sp (63 aa); AAK16536.1|AF331043_16|AF331043 phthalate dioxygenase ferredoxin subunit from Arthrobacter keyseri (64 aa); etc. Probably involved in electron transport for cytochrome P-450 system e.g. downstream ORF Rv0764c|MTCY369.09c probable cytochrome P450 51 from Mycobacterium tuberculosis (451 aa), FASTA scores: opt: [...] | NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase); May serve as electron transfer protein and supply electrons to P450 systems; Belongs to the ferredoxin--NADP reductase type 1 family. | 0.699 |
Rv1824 | fdxD | Rv1824 | Rv3503c | Rv1824, (MTCY1A11.19c), len: 121 aa. Conserved hypothetical membrane protein similar to P28265|SBP_BACSU sbp protein from Bacillus subtilis (121 aa), FASTA scores: opt: 261, E(): 1.9e-12, (38.9% identity in 113 aa overlap). | Rv3503c, (MTV023.10c), len: 63 aa. Probable fdxD,ferredoxin, equivalent to Q9R6Z5|B229_C3_226 hypothetical 9.3 KDA protein from Mycobacterium leprae (83 aa) FASTA scores: opt: 276, E(): 1.8e-13, (75.9% identity in 54 aa overlap). Also similar to several e.g. Q9R6Z5|PHDC from Nocardioides sp. strain KP7 (69 aa), FASTA scores: opt: 177, E(): 2.1e-06, (43.35% identity in 60 aa overlap); Q9X4X8|DITA3 dioxygenase DITA ferredoxin component from Pseudomonas abietaniphila (78 aa), FASTA scores: opt: 166,E(): 1.4e-05, (36.2% identity in 58 aa overlap); P00203|FER_MOOTH from Moorella thermoaceti [...] | 0.803 |
Rv3502c | fdxD | Rv3502c | Rv3503c | Probable short-chain type dehydrogenase/reductase. Possible 17-beta-hydroxysteroid dehydrogenase; Rv3502c, (MTV023.09c), len: 317 aa (start uncertain). Probable short-chain dehydrogenase/reductase, similar to Mycobacterium tuberculosis proteins P71853|Rv3548c|MTCY03C7.08 hypothetical 31.1 KDA protein (304 aa), FASTA scores: opt: 739, E(): 6.2e-35, (45.15% identity in 310 aa overlap); and Q11020|YD50_MYCTU|FABG2|Rv1350|MT1393|MTCY02B10.14 putative oxidoreductase (247 aa), FASTA scores: opt: 475, E(): 5.1e-20, (40.15% identity in 254 aa overlap). Also similar to various dehydrogenases e. [...] | Rv3503c, (MTV023.10c), len: 63 aa. Probable fdxD,ferredoxin, equivalent to Q9R6Z5|B229_C3_226 hypothetical 9.3 KDA protein from Mycobacterium leprae (83 aa) FASTA scores: opt: 276, E(): 1.8e-13, (75.9% identity in 54 aa overlap). Also similar to several e.g. Q9R6Z5|PHDC from Nocardioides sp. strain KP7 (69 aa), FASTA scores: opt: 177, E(): 2.1e-06, (43.35% identity in 60 aa overlap); Q9X4X8|DITA3 dioxygenase DITA ferredoxin component from Pseudomonas abietaniphila (78 aa), FASTA scores: opt: 166,E(): 1.4e-05, (36.2% identity in 58 aa overlap); P00203|FER_MOOTH from Moorella thermoaceti [...] | 0.726 |
cyp124 | cyp51 | Rv2266 | Rv0764c | Probable cytochrome P450 124 Cyp124; Primarily hydroxylates the omega-carbon of a number of methyl-branched lipids, including (2E,6E)-farnesol, phytanate, geranylgeraniol, 15-methylpalmitate and (2E,6E)-farnesyl diphosphate. Also catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25R)-26-hydroxycholest-4- en-3-one (alcohol), (25R)-26-oxocholest-4-en-3-one (aldehyde), to finally yield the carboxylic acid (25R)-3-oxocholest-4-en-26-oate. Cyp124 catalyzes preferencially the oxidation of (25R)-26-hydroxycholest-4-en-3-one diastereomer. Also able to sequen [...] | Lanosterol 14-alpha demethylase; Its precise biological substrate is not known. Catalyzes C14- demethylation of lanosterol, 24,25-dihydrolanosterol and obtusifoliol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol. | 0.402 |
cyp124 | fdxC | Rv2266 | Rv1177 | Probable cytochrome P450 124 Cyp124; Primarily hydroxylates the omega-carbon of a number of methyl-branched lipids, including (2E,6E)-farnesol, phytanate, geranylgeraniol, 15-methylpalmitate and (2E,6E)-farnesyl diphosphate. Also catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25R)-26-hydroxycholest-4- en-3-one (alcohol), (25R)-26-oxocholest-4-en-3-one (aldehyde), to finally yield the carboxylic acid (25R)-3-oxocholest-4-en-26-oate. Cyp124 catalyzes preferencially the oxidation of (25R)-26-hydroxycholest-4-en-3-one diastereomer. Also able to sequen [...] | Probable ferredoxin FdxC; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. | 0.434 |
cyp124 | fdxD | Rv2266 | Rv3503c | Probable cytochrome P450 124 Cyp124; Primarily hydroxylates the omega-carbon of a number of methyl-branched lipids, including (2E,6E)-farnesol, phytanate, geranylgeraniol, 15-methylpalmitate and (2E,6E)-farnesyl diphosphate. Also catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25R)-26-hydroxycholest-4- en-3-one (alcohol), (25R)-26-oxocholest-4-en-3-one (aldehyde), to finally yield the carboxylic acid (25R)-3-oxocholest-4-en-26-oate. Cyp124 catalyzes preferencially the oxidation of (25R)-26-hydroxycholest-4-en-3-one diastereomer. Also able to sequen [...] | Rv3503c, (MTV023.10c), len: 63 aa. Probable fdxD,ferredoxin, equivalent to Q9R6Z5|B229_C3_226 hypothetical 9.3 KDA protein from Mycobacterium leprae (83 aa) FASTA scores: opt: 276, E(): 1.8e-13, (75.9% identity in 54 aa overlap). Also similar to several e.g. Q9R6Z5|PHDC from Nocardioides sp. strain KP7 (69 aa), FASTA scores: opt: 177, E(): 2.1e-06, (43.35% identity in 60 aa overlap); Q9X4X8|DITA3 dioxygenase DITA ferredoxin component from Pseudomonas abietaniphila (78 aa), FASTA scores: opt: 166,E(): 1.4e-05, (36.2% identity in 58 aa overlap); P00203|FER_MOOTH from Moorella thermoaceti [...] | 0.594 |
cyp124 | fprA | Rv2266 | Rv3106 | Probable cytochrome P450 124 Cyp124; Primarily hydroxylates the omega-carbon of a number of methyl-branched lipids, including (2E,6E)-farnesol, phytanate, geranylgeraniol, 15-methylpalmitate and (2E,6E)-farnesyl diphosphate. Also catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25R)-26-hydroxycholest-4- en-3-one (alcohol), (25R)-26-oxocholest-4-en-3-one (aldehyde), to finally yield the carboxylic acid (25R)-3-oxocholest-4-en-26-oate. Cyp124 catalyzes preferencially the oxidation of (25R)-26-hydroxycholest-4-en-3-one diastereomer. Also able to sequen [...] | NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase); May serve as electron transfer protein and supply electrons to P450 systems; Belongs to the ferredoxin--NADP reductase type 1 family. | 0.668 |
cyp124 | fprB | Rv2266 | Rv0886 | Probable cytochrome P450 124 Cyp124; Primarily hydroxylates the omega-carbon of a number of methyl-branched lipids, including (2E,6E)-farnesol, phytanate, geranylgeraniol, 15-methylpalmitate and (2E,6E)-farnesyl diphosphate. Also catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25R)-26-hydroxycholest-4- en-3-one (alcohol), (25R)-26-oxocholest-4-en-3-one (aldehyde), to finally yield the carboxylic acid (25R)-3-oxocholest-4-en-26-oate. Cyp124 catalyzes preferencially the oxidation of (25R)-26-hydroxycholest-4-en-3-one diastereomer. Also able to sequen [...] | Rv0886, (MTCY31.14), len: 575 aa. Probable fprB,ferredoxin/ferredoxin-NADP(+) reductase (NADPH:adrenodoxin oxidoreductase), equivalent to O3306|MLCB57_19 ferredoxin/ferredoxin--NADP reductase from Mycobacterium leprae (555 aa), FASTA scores: E(): 0, (76.6 identity in 560 aa overlap). Also highly similar or similar to others e.g. NP_294219.1|NC_001263 putative ferredoxin/ferredoxin--NADP reductase from Deinococcus radiodurans (479 aa) (N-terminus shorter); P22570|ADRO_HUMAN NADPH:adrenodoxin oxidoreductase from homo sapiens (497 aa), FASTA scores: opt: 624, E(): 3e-30,(39.7% identity in [...] | 0.608 |
cyp51 | Rv0310c | Rv0764c | Rv0310c | Lanosterol 14-alpha demethylase; Its precise biological substrate is not known. Catalyzes C14- demethylation of lanosterol, 24,25-dihydrolanosterol and obtusifoliol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol. | Conserved protein; Rv0310c, (MTCY63.15c), len: 163 aa. Conserved protein, similar to some bile acid dehydratases e.g. P19412|BAIE_EUBSP|98749|D37844|1381566|AAC45413.1|U57489 bile acid-inducible operon protein E from Eubacterium sp (166 aa), FASTA scores: opt: 302, E(): 1e-11, (38.8% identity in 134 aa overlap); AAF22847.1|AF210152_4 bile acid 7a-dehydratase from Clostridium sp. (168 aa). | 0.480 |
cyp51 | Rv0763c | Rv0764c | Rv0763c | Lanosterol 14-alpha demethylase; Its precise biological substrate is not known. Catalyzes C14- demethylation of lanosterol, 24,25-dihydrolanosterol and obtusifoliol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol. | Possible ferredoxin; Rv0763c, (MTCY369.08c), len: 68 aa. Possible ferredoxin, similar to others and related proteins e.g. P18324|FER1_STRGO|SUAB ferredoxin 1 (fd-1) from Streptomyces griseolus (68 aa); AAK31349.1|AF350429_2|AF350429 putative ferredoxin from Nocardioides sp (63 aa); AAK16536.1|AF331043_16|AF331043 phthalate dioxygenase ferredoxin subunit from Arthrobacter keyseri (64 aa); etc. Probably involved in electron transport for cytochrome P-450 system e.g. downstream ORF Rv0764c|MTCY369.09c probable cytochrome P450 51 from Mycobacterium tuberculosis (451 aa), FASTA scores: opt: [...] | 0.990 |
cyp51 | cyp124 | Rv0764c | Rv2266 | Lanosterol 14-alpha demethylase; Its precise biological substrate is not known. Catalyzes C14- demethylation of lanosterol, 24,25-dihydrolanosterol and obtusifoliol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol. | Probable cytochrome P450 124 Cyp124; Primarily hydroxylates the omega-carbon of a number of methyl-branched lipids, including (2E,6E)-farnesol, phytanate, geranylgeraniol, 15-methylpalmitate and (2E,6E)-farnesyl diphosphate. Also catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25R)-26-hydroxycholest-4- en-3-one (alcohol), (25R)-26-oxocholest-4-en-3-one (aldehyde), to finally yield the carboxylic acid (25R)-3-oxocholest-4-en-26-oate. Cyp124 catalyzes preferencially the oxidation of (25R)-26-hydroxycholest-4-en-3-one diastereomer. Also able to sequen [...] | 0.402 |
cyp51 | fdxC | Rv0764c | Rv1177 | Lanosterol 14-alpha demethylase; Its precise biological substrate is not known. Catalyzes C14- demethylation of lanosterol, 24,25-dihydrolanosterol and obtusifoliol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol. | Probable ferredoxin FdxC; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. | 0.450 |
cyp51 | fdxD | Rv0764c | Rv3503c | Lanosterol 14-alpha demethylase; Its precise biological substrate is not known. Catalyzes C14- demethylation of lanosterol, 24,25-dihydrolanosterol and obtusifoliol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol. | Rv3503c, (MTV023.10c), len: 63 aa. Probable fdxD,ferredoxin, equivalent to Q9R6Z5|B229_C3_226 hypothetical 9.3 KDA protein from Mycobacterium leprae (83 aa) FASTA scores: opt: 276, E(): 1.8e-13, (75.9% identity in 54 aa overlap). Also similar to several e.g. Q9R6Z5|PHDC from Nocardioides sp. strain KP7 (69 aa), FASTA scores: opt: 177, E(): 2.1e-06, (43.35% identity in 60 aa overlap); Q9X4X8|DITA3 dioxygenase DITA ferredoxin component from Pseudomonas abietaniphila (78 aa), FASTA scores: opt: 166,E(): 1.4e-05, (36.2% identity in 58 aa overlap); P00203|FER_MOOTH from Moorella thermoaceti [...] | 0.675 |
cyp51 | fprA | Rv0764c | Rv3106 | Lanosterol 14-alpha demethylase; Its precise biological substrate is not known. Catalyzes C14- demethylation of lanosterol, 24,25-dihydrolanosterol and obtusifoliol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol. | NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase); May serve as electron transfer protein and supply electrons to P450 systems; Belongs to the ferredoxin--NADP reductase type 1 family. | 0.682 |