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arsB2 arsB2 Rv3577 Rv3577 lppH lppH Rv1885c Rv1885c Rv3575c Rv3575c Rv2655c Rv2655c oppC oppC Rv0067c Rv0067c Rv1226c Rv1226c rpsF rpsF arsC arsC
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
arsB2Rv3578, (MTCY06G11.25), len: 413 aa. Possible arsB2,arsenical pump integral membrane protein, similar to many e.g. Q9I1J6|ARSB|PA2278 from Pseudomonas aeruginosa (427 aa), FASTA scores: opt: 375, E(): 3.1e-15, (32.15% identity in 429 aa overlap); Q9K8K7|ARSB|BH2999 from Bacillus halodurans (436 aa), FASTA scores: opt: 360, E(): 2.5e-14,(28.7% identity in 432 aa overlap); P52146|ARB2_ECOLI from Escherichia coli (plasmid R46) (429 aa), FASTA scores: opt: 345, E(): 2e-13, (29.8% identity in 426 aa overlap); etc. Also highly similar to Q9KYM0|SC9H11.21c probable membrane efflux protein fro [...] (413 aa)    
Predicted Functional Partners:
Rv3577
Conserved hypothetical protein; Rv3577, (MTCY06G11.24), len: 288 aa (other start sites possible upstream; equivalent to AAK48041 from Mycobacterium tuberculosis strain CDC1551 (379 aa) but shorter 91 aa). Hypothetical protein, showing some similarity to Q9RI88|SCJ11.16c hypothetical 37.9 KDA protein from Streptomyces coelicolor (349 aa) FASTA scores: opt: 285, E(): 1.5e-10, (27.45% identity in 266 aa overlap).
  
    0.875
lppH
Rv3576, (MTCY06G11.23), len: 237 aa. Possible lppH,conserved lipoprotein, similar in part with proteins from Mycobacterium tuberculosis; C-terminus of Q11053|PKNH_MYCTU|PKNH|Rv1266c|MT1304|MTCY50.16 probable serine/threonine-protein kinase (626 aa) FASTA scores: opt: 396, E(): 6.5e-19, (36.0% identity in 200 aa overlap); and with P71740|LPPR|Rv2403c|MTCY253.17 probable lipoprotein protein (251 aa), FASTA scores: opt: 134, E(): 0.087,(22.7% identity in 207 aa overlap). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Note that previously known as pknM.
  
    0.584
Rv1885c
Chorismate mutase; Catalyzes the Claisen rearrangement of chorismate to prephenate. May play some role in the pathogenicity.
 
    0.490
Rv3575c
Transcriptional regulatory protein (probably LacI-family); Rv3575c, (MTCY06G11.22c), len: 359 aa. Probable transcriptional regulator belonging to lacI family, similar to others e.g. BAB53947|MLL8376 from Rhizobium loti (Mesorhizobium loti) (358 aa), FASTA scores: opt: 707, E(): 2.6e-35, (35.5% identity in 355 aa overlap); Q9RRI9|DR2501 from Deinococcus radiodurans (359 aa) FASTA scores: opt: 544, E(): 1.6e-25, (40.35% identity in 347 aa overlap); Q9RL31|SCF51A.34 from Streptomyces coelicolor (347 aa),FASTA scores: opt: 307, E(): 2.9e-11, (30.0% identity in 330 aa overlap); O87590|CELR_ [...]
  
  
 0.475
Rv2655c
Possible PhiRv2 prophage protein; Rv2655c, (MTCY441.24c), len: 475 aa. Hypothetical protein, possibly phiRv2 phage protein (putative primase-like protein) (see citation below). C-terminus similar to P22875|YXIS_SACER hypothetical 28.9 KDA protein (probably does not play a direct role in plasmid integration or excision) from Saccharopolyspora erythraea (Streptomyces erythraeus) plasmid pSE211 (263 aa), FASTA scores: opt: 389, E(): 2.7e-15, (33.45% identity in 269 aa overlap). Weak similarity in N-terminus to O06608|MTCY336.22|Rv1582c Probable phiRV1 phage protein from Mycobacterium tube [...]
  
    0.440
oppC
Rv1282c, (MTCY373.01c-MTCY3H3.01), len: 291 aa. Probable oppC, oligopeptide-transport integral membrane protein ABC transporter (see Braibant et al., 2000),similar to other integral membrane proteins e.g. OPPC_ECOLI|P77664 oligopeptide transport system permease from Escherichia coli (302 aa), FASTA scores: E(): 4.6e-33,(40.7% identity in 275 aa overlap); etc. Also similar to Rv3664c|DPPC probable peptide-transport integral membrane protein from Mycobacterium tuberculosis.
   
  
 0.429
Rv0067c
Possible transcriptional regulatory protein (possibly TetR-family); Rv0067c, (MTV030.10c), len: 189 aa. Possible transcriptional regulator, highly similar to many. Contains probable helix-turn-helix motif from aa 34 to 55 (Score 1523, +4.37 SD).
  
  
 0.424
Rv1226c
Rv1226c, (MTCI61.09c), len: 487 aa. Probable transmembrane protein. Some similarity to AL049841|SCE9.01 Streptomyces coelicolor (436 aa), FASTA scores: opt: 203,E(): 1.2e-05, (29.8% identity in 346 aa overlap).
 
  
 0.422
rpsF
30S ribosomal protein S6 RpsF; Binds together with S18 to 16S ribosomal RNA.
  
    0.408
arsC
Rv2643, (MTCY441.13), len: 498 aa. Probable arsC,arsenical resistance transport integral membrane protein,highly similar or similar to others e.g. Q9L1X4|SC3D9.05 possible arsenic resistance membrane transport protein from Streptomyces coelicolor (368 aa), FASTA scores: opt: 1729,E(): 2.2e-96, (74.3% identity in 358 aa overlap); Q9X8Y0|SCH35.26 putative heavy metal resistance membrane protein from Streptomyces coelicolor (369 aa), FASTA scores: opt: 1729, E(): 2.2e-96, (73.8% identity in 359 aa overlap); Q06598|ACR3_YEAST|ACR3|YPR201W|P9677.2 arsenical-resistance protein from Saccharom [...]
  
  
 0.400
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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