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3821 matches
showing page 1 of 192
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organism
protein
1)
Drosophila melanogaster
AlkB
-
AlkB
, isoform A; Methylcytosine dioxygenase activity; class I DNA-(apurinic or apyrimidinic site) endonuclease activity. It is involved in the biological process described with: oxidation-reduction process.
2)
Escherichia coli K12
alkB
- Oxidative demethylase of N1-methyladenine or N3-methylcytosine DNA lesions; Dioxygenase that repairs alkylated DNA and RNA containing 3- methylcytosine or 1-methyladenine by oxidative demethylation. Has highest activity towards 3-methylcytosine. Has lower activity towards alkylated DNA containing ethenoadenine, and no detectable activity towards 1-methylguanine or 3-methylthymine. Accepts double-stranded and single-stranded substrates. Requires molecular oxygen, alpha- ketoglutarate and iron. Provides extensive resistance to alkylating agents such as MMS and DMS (SN2 agents), but not t [...]
3)
Homo sapiens
ALKBH1 - Nucleic acid dioxygenase ALKBH1; Dioxygenase that acts as on nucleic acids, such as DNA and tRNA. Requires molecular oxygen, alpha-ketoglutarate and iron. A number of activities have been described for this dioxygenase, but recent results suggest that it mainly acts as on tRNAs and mediates their demethylation or oxidation depending on the context and subcellular compartment. Mainly acts as a tRNA demethylase by removing N(1)-methyladenine from various tRNAs, with a preference for N(1)-methyladenine at position 58 (m1A58) present on a stem loop structure of tRNAs. Acts as a regulator o [...]
[a.k.a. hABH, 1.14.11.-, ENST00000555100,
alkB
]
4)
Mus musculus
Alkbh1 - Nucleic acid dioxygenase ALKBH1; Dioxygenase that acts as on nucleic acids, such as DNA and tRNA. Requires molecular oxygen, alpha-ketoglutarate and iron. A number of activities have been described for this dioxygenase, but recent results suggest that it mainly acts as on tRNAs and mediates their demethylation or oxidation depending on the context and subcellular compartment (By similarity). Mainly acts as a tRNA demethylase by removing N(1)- methyladenine from various tRNAs, with a preference for N(1)- methyladenine at position 58 (m1A58) present on a stem loop structure of tRNAs. Act [...]
[a.k.a. NP_001096035, UPI0001889D5F, 211064,
alkB
]
5)
Homo sapiens
ALKBH6 - Alpha-ketoglutarate-dependent dioxygenase
alkB
homolog 6; Probable dioxygenase that requires molecular oxygen, alpha- ketoglutarate and iron; Belongs to the
alkB
family.
[a.k.a. ENSP00000368152, XP_005259414.1, ENSP00000252984]
6)
Homo sapiens
ALKBH7 - Alpha-ketoglutarate-dependent dioxygenase
alkB
homolog 7, mitochondrial; May function as protein hydroxylase; can catalyze auto- hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate. Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death. ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage. Does [...]
[a.k.a. ENSP00000470562, NP_115682.1, AAQ89217.1]
7)
Homo sapiens
ALKBH4 - Alpha-ketoglutarate-dependent dioxygenase
alkB
homolog 4; Dioxygenase that mediates demethylation of actin monomethylated at 'Lys-84' (K84me1), thereby acting as a regulator of actomyosin-processes. Demethylation of actin K84me1 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration. In addition to proteins, also demethylates DNA: specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA, thereby regulating Polycomb silencing (By similarity).
[a.k.a. XM_005250464, 1.14.11.51, BAB15358.1]
8)
Homo sapiens
ALKBH3 - Alpha-ketoglutarate-dependent dioxygenase
alkB
homolog 3; Dioxygenase that mediates demethylation of DNA and RNA containing 1-methyladenosine (m1A). Repairs alkylated DNA containing 1-methyladenosine (m1A) and 3-methylcytosine (m3C) by oxidative demethylation. Has a strong preference for single- stranded DNA. Able to process alkylated m3C within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3. Also acts on RNA. Demethylates N(1)-methyladenosine (m1A) RNA, an epigenetic internal modification of [...]
[a.k.a. UPI0000039EA0, ENST00000529434, BAB70508.1]
9)
Homo sapiens
ALKBH8 - Alkylated DNA repair protein
alkB
homolog 8; Catalyzes the methylation of 5-carboxymethyl uridine to 5- methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain. Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA. Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in [...]
[a.k.a. NX_Q96BT7, ENSP00000374219, NP_620130]
10)
Accumulibacter sp. BA92
alkB
- Alpha-ketoglutarate-dependent dioxygenase
AlkB
.
11)
Acetobacter ascendens
alkB
- Alpha-ketoglutarate-dependent dioxygenase
AlkB
; Oxidative demethylase of N1-methyladenine or N3-methylcytosine DNA lesions; Derived by automated computational analysis using gene prediction method: Protein Homology.
12)
Acetobacter ghanensis
alkB
- Alkylated DNA repair protein.
13)
Achromobacter denitrificans
alkB
- Alpha-ketoglutarate-dependent dioxygenase
AlkB
; Oxidative demethylase of N1-methyladenine or N3-methylcytosine DNA lesions; Derived by automated computational analysis using gene prediction method: Protein Homology.
14)
Achromobacter insolitus
alkB
- Alpha-ketoglutarate-dependent dioxygenase
AlkB
; Oxidative demethylase of N1-methyladenine or N3-methylcytosine DNA lesions; Derived by automated computational analysis using gene prediction method: Protein Homology.
15)
Achromobacter sp. ATCC31444
alkB
- Alpha-ketoglutarate-dependent dioxygenase
AlkB
.
16)
Achromobacter xylosoxidans
alkB
- Alpha-ketoglutarate-dependent dioxygenase
AlkB
.
17)
Acidithiobacillus thiooxidans
alkB
- Alpha-ketoglutarate-dependent dioxygenase
AlkB
.
18)
Acinetobacter baylyi
alkB
- Unannotated protein.
19)
Acinetobacter schindleri
alkB
- Alkane 1-monooxygenase; Protein involved in lipid metabolic process.
20)
Actinoplanes sp. SE50110
alkB
- Alkane 1-monooxygenase.
3821 matches
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