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ramB ramB ramA ramA glxR glxR aceA aceA aceB aceB prpD2 prpD2 rpf2 rpf2 prpD1 prpD1 dtxR dtxR Cgl0111 Cgl0111 mcbR mcbR
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
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gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ramBTranscriptional regulator, MerR family; During growth on glucose, RamB negatively controls the expression of aceA, aceB, ack and pta genes which are involved in acetate metabolism. RamB is also a negative regulator of rpf2 gene expression during growth on acetate as the sole carbon source ; Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family. (474 aa)    
Predicted Functional Partners:
ramA
Bacterial regulatory protein, LuxR family; RamA is a master regulator of acetate metabolism. It positively controls the expression of acnA, aceA, aceB, ack, pta and ramB genes in the presence of acetate. RamA is also a positive regulator of rpf2 gene expression during growth on glucose as the sole carbon source.
   
 
 0.982
glxR
TRANSCRIPTIONAL REGULATOR, CRP/FNR FAMILY; Global transcriptional regulator that complexes with cAMP and binds to specific DNA promoter sites, causing DNA-bending, to regulate transcription. cAMP improves binding to specific DNA sequences, probably by altering protein conformation. Involved in the regulation of gntP and gntK genes, which are involved in gluconate metabolism. May form dimers which bind to the aceB promoter region in the presence of cAMP and repress the glyoxylate bypass genes. It could be a positive regulator of rpf2 gene expression during growth on acetate as the sole [...]
   
  
 0.981
aceA
ISOCITRATE LYASE; Involved in the metabolic adaptation in response to environmental changes. Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates.
 
   
 0.823
aceB
MALATE SYNTHASE; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily.
     
 0.732
prpD2
PROPIONATE CATABOLISM PROTEIN PRPD; Involved in the catabolism of short chain fatty acids (SCFA) via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the dehydration of 2-methylcitrate (2-MC) to yield the cis isomer 2-methyl-aconitate. Could also catalyze the dehydration of citrate and the hydration of cis-aconitate (By similarity); Belongs to the PrpD family.
 
  
 0.710
rpf2
Putative RPF2 precursor, secreted protein; Factor that stimulates resuscitation of dormant cells. Has peptidoglycan (PG) hydrolytic activity. Active in the pM concentration range. Has little to no effect on actively-growing cells. PG fragments could either directly activate the resuscitation pathway of dormant bacteria or serve as a substrate for endogenous Rpf, resulting in low molecular weight products with resuscitation activity (By similarity).
   
  
 0.700
prpD1
PROPIONATE CATABOLIC PROTEIN PRPD; Catalyzes the dehydration of 2-methylcitrate (2-MC) to yield the cis isomer 2-methyl-aconitate; Belongs to the PrpD family.
 
  
 0.690
dtxR
IRON DEPENDENT REGULATORY PROTEIN-DTXR HOMOLOG; Iron-binding repressor of the dipheteria toxin gene expression. May serve as a global regulator of gene expression (By similarity). Represses ripA under iron excess.
   
  
 0.685
Cgl0111
Bacterial regulatory proteins, deoR family.
      
 0.638
mcbR
TetR-type transcriptional regulator of sulfur metabolism.
      
 0.606
Your Current Organism:
Corynebacterium glutamicum
NCBI taxonomy Id: 196627
Other names: C. glutamicum ATCC 13032, Corynebacterium glutamicum ATCC 13032, Corynebacterium glutamicum str. ATCC 13032, Corynebacterium glutamicum strain ATCC 13032
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