STRINGSTRING
hemC hemC hemA hemA hemD hemD hemB hemB cobA cobA hemE hemE hemL hemL hemY hemY hemH hemH hemN hemN cobU cobU
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
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[Homology]
Score
hemCPORPHOBILINOGEN DEAMINASE; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (302 aa)    
Predicted Functional Partners:
hemA
GLUTAMYL-TRNA REDUCTASE; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
  
 0.999
hemD
UROPORPHYRINOGEN III SYNTHASE/METHYLTRANSFERASE.
 0.999
hemB
DELTA-AMINOLEVULINIC ACID DEHYDRATASE; Belongs to the ALAD family.
 
 0.999
cobA
UROPORPHYRINOGEN III SYNTHASE/METHYLTRANSFERASE; Belongs to the precorrin methyltransferase family.
  
 0.994
hemE
UROPORPHYRINOGEN DECARBOXYLASE; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
 0.986
hemL
GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE.
  
 0.984
hemY
PUTATIVE PROTOPORPHYRINOGEN OXIDASE; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
  
 0.908
hemH
FERROCHELATASE PRECURSOR; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.
 
  
 0.902
hemN
PUTATIVE ANAEROBIC COPROPORPHYRINOGEN III OXIDASE; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family.
  
  
 0.847
cobU
COBINAMIDE KINASE / COBINAMIDE PHOSPHATE GUANYLYLTRANSFERASE.
 
   
 0.732
Your Current Organism:
Corynebacterium glutamicum
NCBI taxonomy Id: 196627
Other names: C. glutamicum ATCC 13032, Corynebacterium glutamicum ATCC 13032, Corynebacterium glutamicum str. ATCC 13032, Corynebacterium glutamicum strain ATCC 13032
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