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guaB2 guaB2 guaA guaA purA purA guaB3 guaB3 hpt hpt purH purH Cgl1542 Cgl1542 guaB1 guaB1 Cgl2500 Cgl2500 Cgl0328 Cgl0328 purB purB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
guaB2INOSITOL-MONOPHOSPHATE DEHYDROGENASE; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (506 aa)    
Predicted Functional Partners:
guaA
PUTATIVE GMP SYNTHASE; Catalyzes the synthesis of GMP from XMP.
 0.999
purA
ADENYLOSUCCINATE SYNTHETASE; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
 
 
 0.996
guaB3
IMP dehydrogenase / GMP reductase C terminus.
 
 0.985
hpt
HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
  
 
 0.983
purH
5'-PHOSPHORIBOSYL-5-AMINOIMIDAZOLE-4- CARBOXYLASE.
  
 
 0.955
Cgl1542
Glutamine amidotransferase domain.
  
 
 0.955
guaB1
INOSITOL-MONOPHOSPHATE DEHYDROGENASE.
 
 
0.955
Cgl2500
Xanthosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
  
 0.917
Cgl0328
PROBABLE 5'-NUCLEOTIDASE PRECURSOR; Belongs to the 5'-nucleotidase family.
  
 
 0.903
purB
ADENYLOSUCCINATE LYASE; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
  
 
 0.892
Your Current Organism:
Corynebacterium glutamicum
NCBI taxonomy Id: 196627
Other names: C. glutamicum ATCC 13032, Corynebacterium glutamicum ATCC 13032, Corynebacterium glutamicum str. ATCC 13032, Corynebacterium glutamicum strain ATCC 13032
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