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guaA guaA guaB2 guaB2 guaB3 guaB3 guaB1 guaB1 gmk gmk apt apt hpt hpt purA purA Cgl2500 Cgl2500 pyrG pyrG pheT pheT
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
guaAPUTATIVE GMP SYNTHASE; Catalyzes the synthesis of GMP from XMP. (523 aa)    
Predicted Functional Partners:
guaB2
INOSITOL-MONOPHOSPHATE DEHYDROGENASE; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
 0.999
guaB3
IMP dehydrogenase / GMP reductase C terminus.
 
 0.998
guaB1
INOSITOL-MONOPHOSPHATE DEHYDROGENASE.
 0.998
gmk
PROBABLE GUANYLATE KINASE PROTEIN; Essential for recycling GMP and indirectly, cGMP.
 
 
 0.994
apt
ADENINE PHOSPHORIBOSYLTRANSFERASE; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
  
 0.993
hpt
HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
  
 
 0.982
purA
ADENYLOSUCCINATE SYNTHETASE; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
 
  
 0.962
Cgl2500
Xanthosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
 
 
 0.961
pyrG
CTP SYNTHETASE; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
  
 
 0.955
pheT
PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
  
  
 0.946
Your Current Organism:
Corynebacterium glutamicum
NCBI taxonomy Id: 196627
Other names: C. glutamicum ATCC 13032, Corynebacterium glutamicum ATCC 13032, Corynebacterium glutamicum str. ATCC 13032, Corynebacterium glutamicum strain ATCC 13032
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