node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cgl2500 | guaA | cg2751 | cg0703 | Xanthosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | PUTATIVE GMP SYNTHASE; Catalyzes the synthesis of GMP from XMP. | 0.961 |
Cgl2500 | guaB1 | cg2751 | cg2964 | Xanthosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | INOSITOL-MONOPHOSPHATE DEHYDROGENASE. | 0.927 |
Cgl2500 | guaB2 | cg2751 | cg0699 | Xanthosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | INOSITOL-MONOPHOSPHATE DEHYDROGENASE; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.917 |
Cgl2500 | guaB3 | cg2751 | cg0700 | Xanthosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | IMP dehydrogenase / GMP reductase C terminus. | 0.933 |
Cgl2500 | hpt | cg2751 | cg2985 | Xanthosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.906 |
Cgl2500 | purA | cg2751 | cg3063 | Xanthosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | ADENYLOSUCCINATE SYNTHETASE; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.558 |
apt | gmk | cg1862 | cg1810 | ADENINE PHOSPHORIBOSYLTRANSFERASE; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | PROBABLE GUANYLATE KINASE PROTEIN; Essential for recycling GMP and indirectly, cGMP. | 0.989 |
apt | guaA | cg1862 | cg0703 | ADENINE PHOSPHORIBOSYLTRANSFERASE; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | PUTATIVE GMP SYNTHASE; Catalyzes the synthesis of GMP from XMP. | 0.993 |
apt | guaB2 | cg1862 | cg0699 | ADENINE PHOSPHORIBOSYLTRANSFERASE; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | INOSITOL-MONOPHOSPHATE DEHYDROGENASE; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.590 |
apt | guaB3 | cg1862 | cg0700 | ADENINE PHOSPHORIBOSYLTRANSFERASE; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | IMP dehydrogenase / GMP reductase C terminus. | 0.685 |
apt | hpt | cg1862 | cg2985 | ADENINE PHOSPHORIBOSYLTRANSFERASE; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.984 |
apt | pheT | cg1862 | cg1575 | ADENINE PHOSPHORIBOSYLTRANSFERASE; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. | 0.419 |
apt | purA | cg1862 | cg3063 | ADENINE PHOSPHORIBOSYLTRANSFERASE; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | ADENYLOSUCCINATE SYNTHETASE; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.785 |
apt | pyrG | cg1862 | cg1606 | ADENINE PHOSPHORIBOSYLTRANSFERASE; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | CTP SYNTHETASE; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.470 |
gmk | apt | cg1810 | cg1862 | PROBABLE GUANYLATE KINASE PROTEIN; Essential for recycling GMP and indirectly, cGMP. | ADENINE PHOSPHORIBOSYLTRANSFERASE; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.989 |
gmk | guaA | cg1810 | cg0703 | PROBABLE GUANYLATE KINASE PROTEIN; Essential for recycling GMP and indirectly, cGMP. | PUTATIVE GMP SYNTHASE; Catalyzes the synthesis of GMP from XMP. | 0.994 |
gmk | guaB2 | cg1810 | cg0699 | PROBABLE GUANYLATE KINASE PROTEIN; Essential for recycling GMP and indirectly, cGMP. | INOSITOL-MONOPHOSPHATE DEHYDROGENASE; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.604 |
gmk | guaB3 | cg1810 | cg0700 | PROBABLE GUANYLATE KINASE PROTEIN; Essential for recycling GMP and indirectly, cGMP. | IMP dehydrogenase / GMP reductase C terminus. | 0.657 |
gmk | hpt | cg1810 | cg2985 | PROBABLE GUANYLATE KINASE PROTEIN; Essential for recycling GMP and indirectly, cGMP. | HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.971 |
gmk | pheT | cg1810 | cg1575 | PROBABLE GUANYLATE KINASE PROTEIN; Essential for recycling GMP and indirectly, cGMP. | PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. | 0.553 |