node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cgl0839 | Cgl2786 | cg0961 | cg3086 | Alpha/beta hydrolase fold; Belongs to the AB hydrolase superfamily. MetX family. | Putative L,L-Cystathionine gamma-Lyase. | 0.973 |
Cgl0839 | glyA | cg0961 | cg1133 | Alpha/beta hydrolase fold; Belongs to the AB hydrolase superfamily. MetX family. | Serine Hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.816 |
Cgl0839 | hom | cg0961 | cg1337 | Alpha/beta hydrolase fold; Belongs to the AB hydrolase superfamily. MetX family. | Homoserine Dehydrogenase; Belongs to the homoserine dehydrogenase family. | 0.914 |
Cgl0839 | ilvA | cg0961 | cg2334 | Alpha/beta hydrolase fold; Belongs to the AB hydrolase superfamily. MetX family. | THREONINE DEHYDRATASE; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA (By similarity). | 0.813 |
Cgl0839 | metB | cg0961 | cg2687 | Alpha/beta hydrolase fold; Belongs to the AB hydrolase superfamily. MetX family. | Cystathionine gamma-Synthase. | 0.973 |
Cgl0839 | metX | cg0961 | cg0754 | Alpha/beta hydrolase fold; Belongs to the AB hydrolase superfamily. MetX family. | Homoserine O-Acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the AB hydrolase superfamily. MetX family. | 0.955 |
Cgl0839 | metY | cg0961 | cg0755 | Alpha/beta hydrolase fold; Belongs to the AB hydrolase superfamily. MetX family. | O-Acetylhomoserine (Thiol)-Lyase; Catalyzes the conversion of O-acetyl-L-homoserine (OAH) into homocysteine in the methionine biosynthesis pathway (Ref.4,. Can also use dimethyldisulfide and methanethiol as reduced sulfur sources, leading to the direct formation of methionine. Has weak cystathionine gamma-synthase activity. | 0.997 |
Cgl0839 | serB | cg0961 | cg2779 | Alpha/beta hydrolase fold; Belongs to the AB hydrolase superfamily. MetX family. | Phosphoserine Phosphatase. | 0.800 |
Cgl0839 | tdcB | cg0961 | cg1116 | Alpha/beta hydrolase fold; Belongs to the AB hydrolase superfamily. MetX family. | THREONINE DEHYDRATASE. | 0.813 |
Cgl2786 | Cgl0839 | cg3086 | cg0961 | Putative L,L-Cystathionine gamma-Lyase. | Alpha/beta hydrolase fold; Belongs to the AB hydrolase superfamily. MetX family. | 0.973 |
Cgl2786 | hom | cg3086 | cg1337 | Putative L,L-Cystathionine gamma-Lyase. | Homoserine Dehydrogenase; Belongs to the homoserine dehydrogenase family. | 0.894 |
Cgl2786 | ilvA | cg3086 | cg2334 | Putative L,L-Cystathionine gamma-Lyase. | THREONINE DEHYDRATASE; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA (By similarity). | 0.838 |
Cgl2786 | lysC | cg3086 | cg0306 | Putative L,L-Cystathionine gamma-Lyase. | ASPARTOKINASE LYSC ALPHA and beta SUBUNITs; Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids lysine, threonine, isoleucine and methionine; Belongs to the aspartokinase family. | 0.402 |
Cgl2786 | metB | cg3086 | cg2687 | Putative L,L-Cystathionine gamma-Lyase. | Cystathionine gamma-Synthase. | 0.927 |
Cgl2786 | metX | cg3086 | cg0754 | Putative L,L-Cystathionine gamma-Lyase. | Homoserine O-Acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the AB hydrolase superfamily. MetX family. | 0.943 |
Cgl2786 | metY | cg3086 | cg0755 | Putative L,L-Cystathionine gamma-Lyase. | O-Acetylhomoserine (Thiol)-Lyase; Catalyzes the conversion of O-acetyl-L-homoserine (OAH) into homocysteine in the methionine biosynthesis pathway (Ref.4,. Can also use dimethyldisulfide and methanethiol as reduced sulfur sources, leading to the direct formation of methionine. Has weak cystathionine gamma-synthase activity. | 0.953 |
Cgl2786 | tdcB | cg3086 | cg1116 | Putative L,L-Cystathionine gamma-Lyase. | THREONINE DEHYDRATASE. | 0.862 |
glyA | Cgl0839 | cg1133 | cg0961 | Serine Hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Alpha/beta hydrolase fold; Belongs to the AB hydrolase superfamily. MetX family. | 0.816 |
glyA | ilvA | cg1133 | cg2334 | Serine Hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | THREONINE DEHYDRATASE; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA (By similarity). | 0.949 |
glyA | metX | cg1133 | cg0754 | Serine Hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Homoserine O-Acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the AB hydrolase superfamily. MetX family. | 0.816 |